Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find one of our health articles more useful.
There is more than one way of performing a neurological examination and a clinician should develop their own technique. Poor technique will fail to elicit signs or will produce false results.
See also the separate Neurological History and Examination article which covers the basic principles of examination and technique.
Examination of the upper limbs may be performed more easily with the patient sitting in a chair or standing.
Note if there appears to be any damage to the hands. For example, the mutilation associated with leprosy is not caused by the infection but by failure to respond to noxious stimuli. Pain is a protective mechanism.
On inspection, note the following:
- The resting posture. Note whether there is unusual rotation or clawing of the hand and whether the patient is symmetrical.
- Look for muscle wasting or hypertrophy. Note whether it is focal or diffuse.
- Look for involuntary movements such as tremor, tics, myoclonic jerks, chorea or athetosis.
- Look for muscle fasciculation (sign of lower motor neurone disease process). These are subcutaneous twitches over a muscle belly at rest. Tapping the belly may stimulate fasciculation.
Examination of the sensory system
Examination of each of the sensory modalities:
- Use the light touch of a finger, a piece of cotton wool or a piece of tissue paper.
- It is important to touch and not to stroke, as a moving sensation, such as rubbing and scratching, is conducted along pain pathways.
- Ask the patient to close their eyes and tell you when they feel you touching them.
- Compare each limb in the same position.
- Keep the timing of each touch irregular to avoid anticipation by the patient.
- A logical progression is required. You may want to start testing over the shoulder and to move along the lateral aspect of the arm and up the medial side, as this moves progressively from C4 to T3 dermatomes.
- Note any areas of hypoaesthesia or dysaesthesia.
Sharp touch (pinprick)
- Test using a dedicated disposable pin. A disposable hypodermic needle is too sharp.
- Use the sternal area to establish a baseline for sharpness before you begin.
- Follow the same progression as with light touch with the patient's eyes closed, comparing both upper limbs.
- Ask the patient to report hypoaesthesia (feels blunter) or hyperaesthesia (feels sharper).
- This is often overlooked but it can be important.
- An easy and practical approach is to touch the patient with a tuning fork as the metal feels cold.
- Compare the quality of temperature sensation on arms, face, trunk, hands, legs and feet.
- Containers of warm and cool water may be used for more accurate assessment. Ask the patient to distinguish between warm and cool on different areas of the skin with their eyes closed.
Joint position sense (proprioception)
- Test at the distal interphalangeal joint of the index finger.
- Hold the middle phalanx with one thumb and finger and hold the medial and lateral sides of the distal phalanx with the other. Move the distal phalanx up and down, showing the patient the movement first.
- Ask the patient to close their eyes and move the distal phalanx up and down randomly. Ask the patient to tell you the direction of movement each time.
- Test on both hands.
- If there is an abnormality, move backwards to the proximal interphalangeal joint and so on until joint position sense is normal.
- Use a 128 Hz tuning fork and ensure the tuning fork is vibrating.
- Place it on the sternum to start with so that the patient can feel the sensation.
- Then place it on one of the distal interphalangeal joints of one of the fingers.
- If no vibration is sensed, move backwards to the metacarpophalangeal joint, the wrist, etc.
- Asking the patient to tell you when the tuning fork stops vibrating can be helpful if there is doubt that their vibration sense is intact.
- There are specific two-point discriminators available. If you don't have one, use a paper clip that you can open out.
- Ask the patient to close their eyes.
- Take the patient's index finger in one of your hands.
- Using the discriminator or paper clip, touch the pulp of the finger with either one or two of the testing tips.
- The patient must tell you whether they can feel one or two stimuli.
- Find the minimum distance at which they can discriminate the two tips. Normal is at 3-5 mm.
- Compare both index fingers and repeat for both thumbs.
Examination of the motor system
- This is the resistance felt when a joint is moved passively through its normal range of movement.
- Ask the patient to let their shoulders and arms 'go floppy'.
- Flex and extend their shoulder passively and feel for abnormality of tone.
- Repeat for the elbow and wrist.
- Hypertonia is found in upper motor neurone lesions; hypotonia is found in lower motor neurone lesions and cerebellar disorders.
- Cogwheel rigidity may be found in Parkinson's disease.
- A robust assessment of power is required.
- The Medical Research Council (MRC) has a recommended grading system for power (see table). It has been shown to have good reliability.Some express doubts over the wide range of grade 4.
- Ask the patient to contract the muscle group being tested and then you as the examiner try to overpower that group.
- Test the following:
- Abduction, adduction, flexion and extension of the shoulder.
- Flexion and extension of the elbow.
- Flexion and extension of the wrist.
- Supination and pronation of the forearm.
- Extension of the fingers at the metacarpophalangeal and interphalangeal joints.
- Flexion, extension, adduction and abduction of the fingers and thumbs.
|MRC scale for muscle power|
|0||No muscle contraction is visible.|
|1||Muscle contraction is visible but there is no movement of the joint.|
|2||Active joint movement is possible with gravity eliminated.|
|3||Movement can overcome gravity but not resistance from the examiner.|
|4||The muscle group can overcome gravity and move against some resistance from the examiner.|
|5||Full and normal power against resistance.|
Deep tendon reflexes
- Ensure that the patient is comfortable and relaxed and that you can see the muscle being tested.
- Use a tendon hammer to strike the tendon of the muscle and look for muscle contraction.
- Compare both sides.
- Reflexes can be hyperactive (+++), normal (++), sluggish (+) or absent (-). ± is used when the reflex is only present on reinforcement (see below).
- In the upper limbs:
- Test the biceps jerk (C5, C6): with their arm relaxed, hold the patient's elbow between your thumb and remaining fingers, your thumb being anterior and directly over the biceps tendon. Ideally the elbow should be held at 90°.Elicit the reflex by tapping on your thumb.
- Test the triceps jerk (C6, C7): with their arm relaxed, hold the patient's arm across their lower chest/upper abdomen with one of your hands. Elicit the reflex by tapping over the triceps tendon just above and behind their elbow.
- Test the supinator jerk (C5, C6): ask the patient to relax their arm across their abdomen. Elicit the reflex by tapping over the supinator tendon just above the wrist.
- Test the finger jerk: with their hand relaxed, place the tips of your index and middle fingers across the palmar surface of the patient's proximal phalanges. Tap your fingers lightly with the tendon hammer. There should be slight flexion of the patient's fingers. If there is hyperreflexia, this flexion is exaggerated.
- Test the Hoffmann's reflex: rest the distal interphalangeal joint of the patient's middle finger on the side of your right index finger. Use the tip of your right thumb to flick down on the patient's middle fingertip. Watch for any movement of the patient's thumb as their fingertip springs back up. Normally there is no movement; in hyperreflexia, thumb flexion can be seen.
- If a reflex is difficult to elicit, try 'reinforcement' (the Jendrassik manoeuvre).Ask the patient to clench their teeth or squeeze their knees together while you try to elicit the reflexes again.
- Upper motor neurone lesions usually produce hyperreflexia.
- Lower motor neurone lesions usually produce a diminished or absent response.
- Isolated loss of a reflex can point to a radiculopathy affecting that segment - eg, loss of biceps jerk if there is a C5-C6 disc prolapse.
Examination of co-ordination
The cerebellum helps in the co-ordination of voluntary, automatic and reflex movement. Tests of cerebellar function, however, are only valid if power and tone are normal, and that failure to perform them may also be related to power and tone abnormalities in the upper limb rather than a cerebellar problem. These include:
- The finger-nose test:
- The patient should keep their eyes open.
- Hold one of your fingertips up in front of and a short distance (about 30-40 cm) from the patient.
- Ask the patient to touch the tip of their nose and then to touch your fingertip alternately and repeatedly. You can continuously change your fingertip position to make the test more difficult.
- You can then test for sensory ataxia by asking the patient to close their eyes and to touch the tip of their nose using their outstretched finger.
- Repeat these tests on the other side.
- Look for intention tremor and past-pointing as the patient touches the examiner's fingertip, which can indicate disease of the cerebellar hemispheres.
- Rapid alternating movement:
- The patient needs to have one palm facing upwards.
- They need to touch this palm with the palmar and then dorsal sides of the fingertips of the other hand as quickly as possible. Note that they must lift the second hand between each movement and touch the same point on the other palm without rolling the hand.
- Test both sides. It is normal for the dominant hand to be a little faster at this test.
- Look for dysdiadochokinesis. This is inco-ordination or slow movement when trying to perform this test.
A note about sensation in the hand
- The hand may require more intensive testing. It may be useful to return to it after testing the rest of the arm.
- Test sensation on both the palmar and the dorsal aspects.
- Be aware of the distribution of the median, ulnar and radial nerves:
- The radial nerve supplies sensation to the skin on most of the dorsum of the hand.
- The ulnar nerve supplies sensation to the palmar aspect of the little finger and the palmar aspect of the medial half of the ring finger. It also supplies the distal half of the dorsal aspect of these fingers.
- The median nerve supplies sensation to the palmar aspect of the thumb, index and middle fingers and the lateral half of the ring finger. It also supplies the distal half of the dorsal aspect of these fingers.
Interpreting the findings
The site of any lesion can be determined by looking at the pattern of any dysfunction found.The dermatomal (segmental) and peripheral nerve innervation is labelled in the diagrams above.
- All of the sensory modalities can be affected in peripheral neuropathies and nerve injuries, cervical radiculopathy and spinal injuries.
- If an individual nerve or sensory root is affected, all sensory modalities can be reduced.
- If there is a spinal cord lesion, there may not be equal diminution across all of the sensory modalities: light touch, vibration and joint position sense may remain intact while sharp touch and temperature are lost. This is because the lateral spinothalamic pathways may be damaged while the dorsal columns remain intact. Cervical syringomyelia is an example where this may happen.
- Problems with joint position sense or vibration usually occur distally first.
- Vibration sense can be lost before joint position sense in peripheral neuropathy or myelopathy affecting the dorsal columns.
- Parietal lobe lesions can also cause impairment of two-point discrimination.
- The distal parts of the limbs tend to be affected in polyneuropathy, the legs usually being involved before the arms. A 'glove and stocking' effect is produced.
Further reading and references
Macleod's Clinical Examination; Churchill Livingstone
Paternostro-Sluga T, Grim-Stieger M, Posch M, et al; Reliability and validity of the Medical Research Council (MRC) scale and a J Rehabil Med. 2008 Aug40(8):665-71.
Bhardwaj P, Bhardwaj N; Motor grading of elbow flexion - is Medical Research Council grading good enough? J Brachial Plex Peripher Nerve Inj. 2009 May 134:3.
Keles I, Nilufer B, Mehmet B; The effect of elbow position on biceps tendon reflex. Neurol India. 2004 Sep52(3):350-2.
Gregory JE, Wood SA, Proske U; An investigation into mechanisms of reflex reinforcement by the Jendrassik Exp Brain Res. 2001 Jun138(3):366-74.