Otitis Media with Effusion

Authored by , Reviewed by Dr Helen Huins | Last edited | Meets Patient’s editorial guidelines

This article is for Medical Professionals

Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Glue Ear article more useful, or one of our other health articles.

Treatment of almost all medical conditions has been affected by the COVID-19 pandemic. NICE has issued rapid update guidelines in relation to many of these. This guidance is changing frequently. Please visit https://www.nice.org.uk/covid-19 to see if there is temporary guidance issued by NICE in relation to the management of this condition, which may vary from the information given below.

Synonym: glue ear

Otitis media with effusion (OME), also called glue ear, is characterised by a collection of fluid in the middle-ear cleft. there is chronic inflammation but without signs of acute inflammation. OME is the most common cause of hearing impairment (and the most common reason for elective surgery) in childhood, where it usually follows an episode of acute otitis media (AOM). It is uncommon in adults, in whom Eustachian tube dysfunction is the predominant cause and suspicious aetiologies should be considered.[1]

Ear diagram and glue ear

ear diagram and glue ear

Most cases of OME will resolve spontaneously. However, in affected ears the average hearing loss is 20 decibels (dB) but may be as much as 50 dB. Surgery, in the form of grommet insertion, with or without adenoidectomy, is the most effective treatment in persistent, symptomatic cases.[2]

  • OME is the most common cause of acquired hearing loss in childhood.
  • It is more common between the ages of 1 and 6.
  • The prevalence at the age of 2 is approximately 20%. This drops after the age of 5 and is about 8% between the ages of 7-8.
  • By the age of 10, 80% of children will have had one or more episodes of OME.
  • The incidence of OME in adults is not known, but it is much less common.

Risk factors (children)[1]

  • OME is most common in children aged between 1 and 6 years, in the winter.
  • Most cases are thought to follow an episode of AOM, particularly in children aged under 3 years.
  • OME may then occur because of one or more of the following:
    • Impaired Eustachian tube function reducing aeration of the middle ear.
    • Low-grade infection (bacterial or viral).
    • Chronic colonisation of the adenoids, which may act as a source of bacteria entering the middle-ear cleft.
    • Persistent inflammation.
    • Adenoidal infection or hypertrophy.
  • OME is more common in children with craniofacial malformations, particularly cleft palate.
  • OME is more common in individuals with Down's syndrome, allergic rhinitis and conditions of impaired ciliary motility including cystic fibrosis.
  • In children risk is increased by the following factors:
    • Male gender.
    • Daycare attendance.
    • Frequent upper respiratory tract infection.
    • Having older siblings.
    • Lower parental socio-economic group.
    • Parents who smoke.
    • Winter.
  • One study found a link between gastro-oesophageal reflux in children and OME: it is postulated that reflux increases the level of inflammatory cytokines present in the nasopharynx and middle ear.[3]

Risk factors (adults)[4]

Middle ear fluid in adults needs to be viewed with suspicion, particularly if unilateral. In one series of 167 cases, 4.8% were ascribed to an underlying head and neck tumour.

  • AOM is uncommon in adults and is thus not a common precursor to OME.
  • Eustachian tube dysfunction (ETD) is the main aetiological factor in adults. Causes of ETD include:
    • Infection/inflammation:
      • Severe nasopharyngeal infection (eg, sinusitis) inflames the Eustachian tube openings, resulting in ETD.
      • Severe or chronic allergy may produce the same effect.
    • Anatomical blockage:
      • Severe nasal septal deviation with an obstructed airway.
      • The presence of tonsils and adenoids with obstruction to Eustachian tubes.
      • A nasopharyngeal tumour near Eustachian tube openings.
      • Radiation to the head and neck following cancer treatments.
      • Radical head and neck surgery, on maxillary sinuses and/or palate, that transects the Eustachian tube.
      • Secondary inflammation from allergic rhinitis.
      • Frequent upper respiratory infection. Some viruses may directly damage the Eustachian tube lining, decreasing ciliary clearance.
    • Trauma (usually barotrauma - eg, after a dive or flight).

One Taiwanese study (where nasopharyngeal carcinoma is more prevalent than in Western Europe) found that the incidence of nasopharyngeal carcinoma in adults with OME alone was 5 of 87 patients.[5]

Otitis media (OM) is an umbrella term for a group of complex infective and inflammatory conditions affecting the middle ear. All OM involves pathology of the middle ear and middle ear mucosa. OM is a leading cause of healthcare visits worldwide and its complications are important causes of preventable hearing loss, particularly in the developing world.[7]

There are various subtypes of OM. These include AOM, OME, chronic suppurative otitis media (CSOM), mastoiditis and cholesteatoma. They are generally described as discrete diseases  but in reality there is a great degree of overlap between the different types. OM can be seen as a continuum/spectrum of diseases:
  • AOM is acute inflammation of the middle ear and may be caused by bacteria or viruses. A subtype of AOM is acute suppurative OM, characterised by the presence of pus in the middle ear. In around 5% the eardrum perforates.
  • OME is a chronic inflammatory condition without acute inflammation, which often follows a slowly resolving AOM. There is an effusion of glue-like fluid behind an intact tympanic membrane in the absence of signs and symptoms of acute inflammation. 
  • CSOM is long-standing suppurative middle ear inflammation, usually with a persistently perforated tympanic membrane.
  • Mastoiditis is acute inflammation of the mastoid periosteum and air cells occurring when AOM infection spreads out from the middle ear.
  • Cholesteatoma occurs when keratinising squamous epithelium (skin) is present in the middle ear as a result of tympanic membrane retraction.


  • Hearing loss is the usual presenting symptom, although this is easily missed in very young children. Hearing loss is not invariably present. Hearing loss in children may present as:
    • Mishearing, difficulty with communication in a group, listening to the TV at excessively high volumes or needing things to be repeated.
    • Lack of concentration, withdrawal.
    • Impaired speech and language development.
    • Impaired school progress.
  • Mild intermittent ear pain with fullness or popping.
  • There may be a history of recurrent ear infection, upper respiratory tract infections or nasal obstruction.
  • Occasionally balance problems may be a feature.

Examination findings

  • Opacification of the drum (other than due to scarring).
  • There are usually no signs of inflammation or discharge on examination.
  • Loss of the light reflex, or a more diffused light reflex.
  • Indrawn, retracted, or concave drum.
  • Decreased or absent mobility of the drum.
  • Presence of bubbles or fluid level.
  • Yellow or amber colour change to the drum.
  • Fullness or bulging of the drum, although this is not typical.
  • A pneumatic tympanogram typically shows an immobile eardrum or negative middle ear pressure (which retracts the drum). This is not generally available in primary care in the UK.

Adult OME is more often unilateral than in children, which may reflect the underlying causes.

Typical symptoms include:

  • OME in adults usually presents with hearing loss.
  • A feeling of aural fullness.
  • Crackling or popping tinnitus.
  • A foreign body sensation in the external auditory canal.
  • Mild, diffuse aural pain.
  • Complaints of acute ear pain are rare.
  • A vague sense of unsteadiness without true vertigo may be seen.

Children with persistent symptoms or signs should be referred for a hearing test or directly to an ENT specialist if GP access to audiometry is not available.

Not all cases require referral. Spontaneous resolution often occurs, so it worth observing for three months to see whether the symptoms and signs resolve ('active observation').[9]One study found that 50% of children with 20 dB hearing loss will recover in three months without treatment.

Hearing assessment

  • Hearing tests typically show a mild conductive hearing loss.
  • Pure-tone audiometry is the best way to assess hearing in children of 4 years or older.[10]
  • The McCormick Toy Test and the distraction tests are suitable for children younger than 4 years:[11]
    • These tests do not provide a quantitative level of loss.
  • A hearing loss of 25 dB or greater in the better ear is usually important:
    • With a hearing loss of 30 dB, normal conversation may sound like a soft whisper.[12]
  • The National Institute for Health and Care Excellence (NICE) recommends a second hearing test three months after the first.

OME has a lower prevalence in adults and is frequently associated with other underlying diagnoses. Unilateral OME in an adult is a suspicious finding.

Paranasal sinus disease is the main underlying cause of OME in adults, accounting for two thirds of cases in one series. However, other causes included head and neck tumours (4.8%).

Adults with OME should therefore be fully evaluated for underlying conditions.

Nasopharyngeal tumours are relatively more common in patients of Southern Chinese ethnicity. One study in Taiwan suggested that all adults with OME in whom a cause is not clearly understood should have full nasopharyngeal evaluation, including biopsy.[5]

Management in children


Give written information about OME to parents of affected children and reassure parents that:

  • OME is a self-limiting illness and 90% of children will have complete resolution within one year, although recurrence is common.
  • There is no proven benefit from treatment with any medication or alternative therapy.
  • Parental smoking increases the risk of OME.
  • Advise parents of children with hearing loss to assist them by:
    • Facing their child when speaking to them.
    • Slowing their speech.
    • Keeping speech clear.
    • Increasing speech volume slightly.
    • Turning off competing stimuli such as radio or TV.
    • Encouraging daily reading, which helps language development.

Hearing aiding

  • NICE recommends hearing aids for children with bilateral OME and hearing loss where surgery is not acceptable or is contra-indicated.
  • Each case needs to be considered on its own merits: the need to assist hearing during a period of active observation, for example, has to be weighed against evidence that the use of aids in children can increase anxiety.[13]

Pharmacological[14, 15]

Medical management (eg, antibiotics, topical or systemic antihistamines or decongestants) is not recommended.

  • A Cochrane review found that current guidelines developed by both the UK's National Collaborating Centre for Women's and Children's Health (2008) and the American Academy of Pediatrics (2004) recommends against using oral or topical nasal steroids in treating children with OME.
  • High-quality evidence of multiple short- and long-term outcomes repeatedly and unequivocally demonstrated no benefit for use of antihistamines and decongestants over placebo for treating OME. Additionally, the reviewed studies found evidence of side-effects and harms with the use of these medications.
  • A second Cochrane review looked at the use of antibiotics in OME in over 3,000 children and concluded that the results do not support the routine use of antibiotics for children up to 18 years of age with OME. The largest effects of antibiotics were seen with continuous use over weeks or months but these were felt to be balanced by the potential adverse effects of this approach, including side-effects and increased bacterial resistance.
  • The treatment of adults with uncomplicated OME is generally extrapolated from that of children. If there is an underlying cause then this should be treated appropriately. There is a lack of clear evidence on the treatment of uncomplicated OME in adults.


  • Most children who present with OME can be safely managed with active observation.
  • Earlier referral may be considered for children with significant hearing difficulties, particularly if there are developmental, social or educational difficulties, or if there is pre-existing hearing impairment.
  • Active observation is not appropriate for children who have significant disability or who have associated high-risk conditions - eg, Down's syndromecleft palate.
  • Children with hearing loss demonstrated by the second hearing test should be referred to ENT.

Active observation[9]

The use of surgical treatment for OME has fallen dramatically in recent years with the recognition that many cases resolve with active observation.


This is a harmless technique used to induce a Valsalva manoeuvre. NICE does not oppose its use but the evidence base is limited.

  • The recommended method is with an Otovent® device. A balloon is inflated by blowing into it from one nostril, while sealing the other nostril with a finger. This action results in an increase in intranasal pressure and opening of the Eustachian tube (ie a Valsalva manoeuvre).

Surgery[1, 9]

NICE recommends that children who most benefit from surgery are those with:

  • Persistent bilateral OME lasting three or more months.
  • A hearing loss in the best ear of 25-30 dB or worse, averaged at 0.5, 1, 2 and 4 kHz.
  • Children with better hearing but who have social, educational or developmental difficulties may exceptionally also benefit from surgical treatment.

The application of these criteria has generated concern that surgery may be withheld from children who would otherwise benefit from it.

Insertion of grommets (ventilation tubes)
This is the first-line treatment.

  • NICE concludes that insertion of grommets results in an improvement in hearing over a twelve-month period, which starts to tail off after six months. There is little evidence that language or speech development improves in the long term.[1]
  • Tympanosclerosis frequently occurs after grommet insertion, although the long-term consequences of this are uncertain.[1]
  • Infection after grommet insertion may occur and there is also a slightly increased incidence of chronic perforation.[1]
  • Grommet insertion has traditionally been performed under general anaesthetic, although it is possible to perform the procedure under local anaesthetic. Topical anaesthetic is applied to the ear canal approximately 30 minutes prior to the procedure.

A Cochrane review of 2011 concluded that:[14]

  • In children with hearing loss induced by OME the effect of grommets on hearing appears small and diminishes after 6-9 months (by which time natural resolution leads to improved hearing in those children not treated surgically).
  • No effect was found on other child outcomes but data were sparse in this area.
  • No study has been performed in children with established speech, language or developmental problems, so no conclusion can be drawn in the case of these children.

Adenoidectomy is recommended only if recurrent upper respiratory tract symptoms are a feature.

Grommets and adenoidectomy reduce time with OME and improve hearing in the short term. Both treatments have associated harms. Large, well-controlled studies could help resolve the risk:benefit ratio by measuring AOM recurrence, functional outcomes, quality of life and long-term outcomes. Further research is needed to support treatment decisions in sub-populations, particularly in patients with comorbidities.[16]

Laser myringotomy[17, 18, 19]

  • Myringotomy is an incision in the tympanic membrane. Historically, in the pre antibiotic era, it was performed with a myringotomy knife to allow drainage (or suction) of middle ear fluid (it was described by Sir Ashley Cooper in 1802). It was popular until the arrival of antibiotics in the 1940s.
  • Laser myringotomy (also called laser fenestration) uses a laser diode to incise the tympanic membrane, with a view to allowing middle ear fluid sampling or drainage without general anaesthetic or grommet insertion. (Laser diodes are tiny, portable, low-voltage lasers which produce a cone rather than a cylinder of light.) Laser myringotomy is safe, quick and painless and the hole it leaves in the tympanic membrane remains patent for longer than those made by incision with a blade. However, the duration of patency it produces is still too short (3-4 weeks) to achieve long-term clearance of the effusion in OME in adults or children.
  • Laser diodes may also be used to perform myringotomy prior to ventilation tube insertion.

Management in adults

Adults with persisting OME and no sinister underlying cause which needs treatment are managed as for children. Outcomes for surgery and myringotomy appear to be similar.

  • OME may adversely affect speech, language development, behaviour and education:
    • Evidence shows only a weak association between OME and delayed speech and language development. Most studies suggest that any adverse effect is temporary in the majority of children.[1]
  • One study found an increased incidence in anxiety/depression disorders and attention deficit disorders compared with controls.[20]
  • One study found that A (H1N1) pandemic influenza vaccine afforded a two- to nine-fold protection against OME.[3]
  • Pneumococcal vaccine did not confer similar benefits.[21]
  • Spontaneous resolution of OME is common in children. The effusion normally resolves in 6-10 weeks and 50-90% of children are clear within 12 weeks.
  • However, 30-40% of children have recurrent episodes and 5-10% of episodes last for more than a year.
  • In most children, problems with OME do not persist beyond early childhood but sometimes they can last much longer.
  • The impact of OME is magnified if there are co-existing problems such as deafness of other causes, visual problems, or speech or educational difficulties.
  • Poorer prognosis in children is associated with multiple occurrences and mucoid effusion.
  • Poorer prognosis in adults with no sinister underlying cause prognosis is associated with a history of previous grommet use.

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Further reading and references

  1. Otitis media with effusion; NICE CKS, March 2011 (UK access only)

  2. Atkinson H, Wallis S, Coatesworth AP; Otitis media with effusion. Postgrad Med. 2015 May127(4):381-5. doi: 10.1080/00325481.2015.1028317.

  3. Cuhaci Cakir B, Beyazova U, Kemaloglu YK, et al; Effectiveness of pandemic influenza A/H1N1 vaccine for prevention of otitis media in children. Eur J Pediatr. 2012 Nov171(11):1667-71. doi: 10.1007/s00431-012-1797-2. Epub 2012 Sep 30.

  4. Finkelstein Y, Ophir D, Talmi YP, et al; Adult-onset otitis media with effusion. Arch Otolaryngol Head Neck Surg. 1994 May120(5):517-27.

  5. Ho KY, Lee KW, Chai CY, et al; Early recognition of nasopharyngeal cancer in adults with only otitis media with effusion. J Otolaryngol Head Neck Surg. 2008 Jun37(3):362-5.

  6. Qureishi A, Lee Y, Belfield K, Birchall JP, Daniel M. Update on otitis media – prevention and treatment. Infection and Drug Resistance. 2014;7:15-24. doi:10.2147/IDR.S39637.

  7. Monasta L, Ronfani L, Marchetti F, et al; Burden of disease caused by otitis media: systematic review and global estimates. PLoS One. 20127(4):e36226. Epub 2012 Apr 30.

  8. Chang C-W, Yang Y-W, Fu C Y, Shiao A-S: Differences between children and adults with otitis media with effusion treated with CO2 laser myringotomy Journal of the Chinese Medical Association 75 (2012) 29e35

  9. Surgical management of children with otitis media with effusion (OME); NICE Clinical Guideline (February 2008)

  10. Bamford J, Fortnum H, Bristow K, et al; Current practice, accuracy, effectiveness and cost-effectiveness of the school entry hearing screen. Health Technol Assess. 2007 Aug11(32):1-168, iii-iv.

  11. Hall AJ, Munro KJ, Heron J; Developmental changes in word recognition threshold from two to five years of age in children with different middle ear status. Int J Audiol. 2007 Jul46(7):355-61.

  12. Screening for otitis media with effusion: recommendation statement from the Canadian Task Force on Preventive Health Care; CMAJ. 2001 Oct 16165(8):1092-3.

  13. Theunissen SC, Rieffe C, Kouwenberg M, et al; Anxiety in children with hearing aids or cochlear implants compared to normally hearing controls. Laryngoscope. 2012 Mar122(3):654-9. doi: 10.1002/lary.22502. Epub 2012 Jan 17.

  14. Browning GG, Rovers MM, Williamson I, et al; Grommets (ventilation tubes) for hearing loss associated with otitis media with effusion in children. Cochrane Database Syst Rev. 2010 Oct 6(10):CD001801. doi: 10.1002/14651858.CD001801.pub3.

  15. van Zon A, van der Heijden GJ, van Dongen TM, et al; Antibiotics for otitis media with effusion in children. Cochrane Database Syst Rev. 2012 Sep 129:CD009163. doi: 10.1002/14651858.CD009163.pub2.

  16. Wallace IF, Berkman ND, Lohr KN, et al; Surgical treatments for otitis media with effusion: a systematic review. Pediatrics. 2014 Feb133(2):296-311. doi: 10.1542/peds.2013-3228. Epub 2014 Jan 6.

  17. Koopman JP, Reuchlin AG, Kummer EE, et al; Laser myringotomy versus ventilation tubes in children with otitis media with Laryngoscope. 2004 May114(5):844-9.

  18. Zanetti D, Piccioni M, Nassif N, et al; Diode laser myringotomy for chronic otitis media with effusion in adults. Otol Neurotol. 2005 Jan26(1):12-8.

  19. Youssef TF, Ahmed MR; Laser-assisted myringotomy versus conventional myringotomy with ventilation tube insertion in treatment of otitis media with effusion: Long-term follow-up. Interv Med Appl Sci. 2013 Mar5(1):16-20. doi: 10.1556/IMAS.5.2013.1.3. Epub 2013 Mar 19.

  20. Gouma P, Mallis A, Daniilidis V, et al; Behavioral trends in young children with conductive hearing loss: a case-control study. Eur Arch Otorhinolaryngol. 2011 Jan268(1):63-6. Epub 2010 Jul 28.

  21. El-Makhzangy AM, Ismail NM, Galal SB, et al; Can vaccination against pneumococci prevent otitis media with effusion? Eur Arch Otorhinolaryngol. 2012 Sep269(9):2021-6. doi: 10.1007/s00405-012-1975-x. Epub 2012 Mar 3.

i have a sound in my ear wich goes away when i use eardrups, what could be the problem?

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