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Treatment of almost all medical conditions has been affected by the COVID-19 pandemic. NICE has issued rapid update guidelines in relation to many of these. This guidance is changing frequently. Please visit https://www.nice.org.uk/covid-19 to see if there is temporary guidance issued by NICE in relation to the management of this condition, which may vary from the information given below.
Pityriasis versicolor is a common skin complaint in which flaky discoloured patches appear mainly on the chest and back. It is sometimes called tinea versicolor, although the term 'tinea' should strictly refer to infection with a dermatophyte fungus.
It is caused by the proliferation of the lipophilic fungus of the genus Malassezia (formerly known as Pityrosporum) which is part of the normal flora of human skin. Usually Malassezia spp. grow sparsely in the seborrhoeic areas (scalp, face and chest) without causing a rash. When the fungus changes from its normal form to a pathological mycelial form, it causes infection and a rash. At least fourteen different species of Malassezia spp. have been identified.The most common species cultured from pityriasis versicolor patches is Malassezia globosa.
Pityriasis versicolor most commonly affects teenagers and young adults when the sebaceous glands are more active. It is relatively common in hot, humid climates and mainly seen in the UK during spells of hot humid weather. In tropical countries prevalence has been estimated to be as high as 30-40%, whereas in the UK it is around 1-4%.
Most infections occur in normal healthy people but the following factors increase the risk:
- Hyperhidrosis or increased physical activity causing sweating.
- Occlusive clothes, dressings or ointments.
- Immunosuppression or immune deficiency.
- It usually has an insidious onset and in some cases it can be several months before it is noticed.
- Macular lesions and patches of altered pigmentation are seen primarily on the trunk.
- These lesions frequently spread to the neck, upper arms and abdomen and can sometimes occur at other sites. The rash is usually seen in sebum-rich sites. The face may be affected in children.
- There is a superficial scale which is best seen by stretching the affected skin, or scraping the surface.
- Sometimes the patches start scaly and brown and then resolve through a non-scaly and white stage.
- Itching, if present, is mild.
- Pityriasis versicolor is not contagious, as it is a commensal yeast.
- Pityriasis alba.
- Tinea corporis.
- Seborrhoeic dermatitis (may co-exist).
- Pityriasis rosea.
- Guttate psoriasis.
- Discoid (nummular) eczema.
- Secondary syphilis.
- Mycosis fungoides.
Investigations are not usually necessary, as the diagnosis is often made clinically. They may be necessary if the condition is not responding to treatment or if the diagnosis is unclear. Where required, skin scrapings can be sent for microscopy. The spores and hyphae have a 'spaghetti and meatball' appearance on potassium hydroxide wet-mount examination. Yellow to yellow-green fluorescence may be observed on examination of affected areas with a Wood's light. There is no benefit of fungal culture, as the organism is part of the normal flora and isolation is therefore not necessarily relevant.
- Pityriasis versicolor should be treated initially with topical antifungals, especially topical imidazoles - eg, clotrimazole, miconazole, econazole and ketoconazole in various formulations (creams or shampoos).
- Ketoconazole shampoo (Nizoral®) is usually first-line and should be applied on to affected areas and made into a lather; it should then be left for three to five minutes before washing off. This should be repeated daily for five days.
- Selenium shampoo can be used as an alternative (its use is unlicensed). It should be diluted with water (to reduce the likelihood of irritation), applied to affected areas for ten minutes and then rinsed off. This should be repeated daily for seven to ten days. This is contra-indicated in pregnancy.
- If very small areas are involved, or in pregnancy, antifungal imidazole creams such as clotrimazole may be used as an alternative. The cream should be applied twice a day for two to three weeks.
- In widespread or resistant cases, prescribe itraconazole 200 mg daily for seven days (although terbinafine is active against dermatophytes (eg, tinea), it actually has little effect on yeast infections). Alternatively, fluconazole may be used - 50 mg daily for two to four weeks, or 300-400 mg weekly for one to three weeks.
- Patients should be advised that it can take several months for the skin colour to return to normal.
- Antifungal treatment should be repeated when the scaly component of pityriasis versicolor recurs.
- Recurrences of pityriasis versicolor are common.
- For those who are prone to develop recurrent episodes in the sun, they can be advised to use ketoconazole shampoo prophylactically once a day for three days prior to their sun exposure.
- Ketoconazole or selenium sulfide shampoo may be applied for five to ten minutes one to four times monthly for those who have frequent recurrences.
- Oral antifungal treatment may occasionally be prescribed monthly as a preventative measure in those who have frequent recurrences (eg, fluconazole 300 mg per month).
- Infection often leads to hypopigmentation of the skin, which may persist for months after successful treatment.
- Hypopigmentation will not clear until the skin becomes tanned again; however, if the rash is not scaly when scratched then the infection can be considered as cleared.
- Pink or brown types of pityriasis versicolor generally clear satisfactorily with treatment but the rash often recurs.
- The pale type of pityriasis versicolor also generally clears up with treatment and the skin eventually tans normally with sun exposure.
- White marks are occasionally permanent and resistant to antifungal treatment.
Further reading and references
Pityriasis versicolor; DermNet NZ
Pityriasis Versicolor; DermIS (Dermatology Information System)
Kelly BP; Superficial fungal infections. Pediatr Rev. 2012 Apr33(4):e22-37. doi: 10.1542/pir.33-4-e22.
Nenoff P, Kruger C, Mayser P; Cutaneous Malassezia infections and Malassezia associated dermatoses: An update. Hautarzt. 2015 Jun66(6):465-84
Pityriasis versicolor; NICE CKS, March 2016 (UK access only)
Renati S, Cukras A, Bigby M; Pityriasis versicolor. BMJ. 2015 Apr 7350:h1394. doi: 10.1136/bmj.h1394.
British National Formulary (BNF); NICE Evidence Services (UK access only)