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Prolonged diarrhoea or vomiting

Medical Professionals

Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Gastrointestinal malabsorption article more useful, or one of our other health articles.

Both vomiting and diarrhoea are often self-limiting and have a benign cause and prognosis. However, it is essential to make a thorough assessment to ensure there is not a more serious aetiology requiring prompt intervention. The arbitrary use of symptomatic treatments without a clear diagnosis is inappropriate. Continued vomiting and diarrhoea require reassessment and reconsideration of the previously assumed diagnosis.

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There are separate articles on Nausea and Vomiting in Palliative Care, Persistent Nausea or Vomiting, Nausea and Vomiting in Pregnancy (Hyperemesis Gravidarum) and Dyspepsia.

There is no consistent definition for persistent vomiting; it may be described in number of episodes per day, or number of days or weeks on which vomiting has occurred.2

Clinical assessment

  • The main priorities on assessment include the presence and degree of dehydration (especially in infants, young children and the elderly) and the underlying cause, particularly any possibility of a serious underlying cause requiring urgent admission or referral.

  • Associated headache may occur with migraine but meningitis, subarachnoid haemorrhage and raised intracranial pressure also need to be considered.

  • Abnormal clinical signs in the abdomen may include localised pain, tenderness and guarding (eg, acute appendicitis, acute cholecystitis) or absent bowel sounds (acute gastrointestinal obstruction).

  • Associated anorexia and weight loss indicate possible malignancy.

  • Vomiting blood may indicate peptic ulcer disease, Mallory-Weiss tear, oesophageal varices, gastro-oesophageal reflux disease, or malignancy.

  • Genitourinary causes should be considered - eg, testicular torsion or acute epididymitis in men, and ruptured ovarian cyst or ovarian torsion in women.

  • Pregnancy in women, medication, occupation and recent travel should also be considered in the assessment of the cause for the vomiting.

Differential diagnosis3

There are very many causes of vomiting. Consider the possible subheadings:

  • Functional.

  • Gastrointestinal.

  • Iatrogenic eg, chemotherapy.

  • Medication.

  • Metabolic.

  • Miscellaneous (including pregnancy).

  • Neurological.

  • Psychiatric.

  • Vestibular.


  • Blood tests: FBC, ESR or CRP, renal function and electrolytes, LFTs, amylase, glucose, calcium.

  • Urine: urinalysis, microscopy and culture, pregnancy test.

  • Further assessment for possible underlying infection may include stool cultures, blood cultures, lumbar puncture.

  • Ultrasound: gallstones, liver metastases, urinary tract obstruction.

  • CXR (malignancy), abdominal X-ray (gastrointestinal obstruction).

  • Barium meal, small bowel enema, barium enema.

  • Upper gastrointestinal endoscopy.

  • CT/MRI scan: abdominal and intracranial.


Severe or persistent vomiting may cause:


There are separate articles on Childhood Diarrhoea, Chronic Diarrhoea in Adults, Gastroenteritis in Adults and Older Children, Traveller's Diarrhoea, Faecal Incontinence and Rectal Bleeding in Adults.

Clinical assessment 4

  • The main principles for assessment are the same as for vomiting, ie assessment of dehydration, excluding a serious cause and making a specific diagnosis to enable specific treatment.

  • It is essential to make an assessment of the degree of diarrhoea, as there is considerable variation in normal bowel habit and patient perception.

  • Associated weight loss usually indicates a serious underlying cause - eg, inflammatory bowel disease or malignancy.

  • Constipation with overflow should be considered, especially in the elderly.

  • Recent foreign travel may be important in terms of indicating a cause for the diarrhoea.5

Differential diagnosis

There are very many. It may be useful to consider them in subgroups:6

  • Watery diarrhoea - functional disorders, eg, irritable bowel syndrome.

  • Watery diarrhoea - secretory disorders, eg, bile acid malabsorption.

  • Watery diarrhoea - osmotic disorders, eg, carbohydrate malabsorption.

  • Fatty diarrhoea - malabsorptive disorders, eg, amyloidosis.

  • Fatty diarrhoea - maldigestive disorders, eg, pancreatic exocrine insufficiency.

  • Inflammatory, eg, inflammatory bowel disease, malignancy.


  • Blood tests: FBC (raised white cell count with infection), CRP (raised in inflammation or malignancy); renal function and electrolytes, LFTs, TFTs, Coeliac serology.

  • Specific investigations for rarer causes might be undertaken in secondary care and may include serum gastrin (Zollinger-Ellison syndrome), calcitonin (medullary carcinoma of thyroid) or vasoactive intestinal polypeptide-secreting tumour (VIPoma).

  • Stool: microscopy, culture and sensitivities; faecal immunochemical test (FIT) kit, faecal fats (malabsorption).

  • Ultrasound/CT scan: liver metastases.

  • Barium enema, small bowel enema.

  • Proctoscopy, sigmoidoscopy, colonoscopy.

  • Biopsy: rectal biopsy (Crohn's disease), in association with colonoscopy (eg, ulcerative colitis), jejunal biopsy (coeliac disease).


Prolonged diarrhoea may cause:

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Vomiting and diarrhoea treatment and management

General principles of management of vomiting or diarrhoea

  • Refer urgently if there is significant dehydration or a possible serious underlying cause (eg, acute admission for a patient with an acute abdomen or serious infective cause; urgent referral for possible malignancy).

  • An urgent referral for endoscopy or to a specialist with expertise in upper gastrointestinal cancer should be made for any patient of any age with dyspepsia who presents with persistent vomiting.8

  • In patients with persistent vomiting and weight loss in the absence of dyspepsia, upper gastro-oesophageal cancer should be considered and, if appropriate, an urgent referral should be made.8

  • An urgent referral should be made for patients aged 60 years and older, with a change in bowel habit to looser stools and/or more frequent stools persisting for six weeks or more.8

  • People with diabetes are at particular risk of dehydration and electrolyte imbalance, and so should have a lower threshold for hospital admission.

  • Correction of fluid and electrolyte imbalance.

  • Diagnosis and specific treatment of any underlying cause.

  • Symptomatic treatment should only be used as part of a management plan with a definite diagnosis of the cause of the vomiting and/or diarrhoea.

Further reading and references

  • Diarrhoea - adult's assessment; NICE CKS, May 2021 (UK access only)
  • Davis A, Bryant JH; Cyclic Vomiting Syndrome.
  • Huang IH, Schol J, Khatun R, et al; Worldwide prevalence and burden of gastroparesis-like symptoms as defined by the United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis. United European Gastroenterol J. 2022 Oct;10(8):888-897. doi: 10.1002/ueg2.12289. Epub 2022 Aug 19.
  1. Heckroth M, Luckett RT, Moser C, et al; Nausea and Vomiting in 2021: A Comprehensive Update. J Clin Gastroenterol. 2021 Apr 1;55(4):279-299. doi: 10.1097/MCG.0000000000001485.
  2. Morra ME, Elshafay A, Kansakar AR, et al; Definition of "persistent vomiting" in current medical literature: A systematic review. Medicine (Baltimore). 2017 Nov;96(45):e8025. doi: 10.1097/MD.0000000000008025.
  3. Lacy BE, Parkman HP, Camilleri M; Chronic nausea and vomiting: evaluation and treatment. Am J Gastroenterol. 2018 May;113(5):647-659. doi: 10.1038/s41395-018-0039-2. Epub 2018 Mar 15.
  4. Gomez-Escudero O, Remes-Troche JM; Approach to the adult patient with chronic diarrhea: A literature review. Rev Gastroenterol Mex (Engl Ed). 2021 Oct-Dec;86(4):387-402. doi: 10.1016/j.rgmxen.2021.08.007. Epub 2021 Aug 11.
  5. Slack A; Parasitic causes of prolonged diarrhoea in travellers - diagnosis and management. Aust Fam Physician. 2012 Oct;41(10):782-6.
  6. Burgers K, Lindberg B, Bevis ZJ; Chronic Diarrhea in Adults: Evaluation and Differential Diagnosis. Am Fam Physician. 2020 Apr 15;101(8):472-480.
  7. Arasaradnam RP, Brown S, Forbes A, et al; Guidelines for the investigation of chronic diarrhoea in adults: British Society of Gastroenterology, 3rd edition. Gut. 2018 Aug;67(8):1380-1399. doi: 10.1136/gutjnl-2017-315909. Epub 2018 Apr 13.
  8. Suspected cancer: recognition and referral; NICE guideline (2015 - last updated October 2023)

Article history

The information on this page is written and peer reviewed by qualified clinicians.

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