Reflexic Anoxic Seizures

Authored by Dr Colin Tidy, 11 Feb 2016

Reviewed by:
Dr Adrian Bonsall, 11 Feb 2016

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Synonyms: pallid syncopal attack, white breath-holding attacks 

Reflex anoxic seizures are paroxysmal, spontaneously-reversing brief episodes of asystole triggered by pain, fear or anxiety. Anoxic seizures are non-epileptic events caused by a reflex asystole due to increased vagal responsiveness. They are often misdiagnosed as epilepsy.[1]

  • Reflex anoxic seizures occur mainly in young children (infants and preschool children) but can occur at any age.
  • Misdiagnosis is common but it is estimated that 0.8% of preschool children are affected.
  • One study of children referred for 'fits, faints and funny turns' found that 23% had one of the childhood epilepsies (with 48% of these having a specific epilepsy syndrome). Syncope was the most common cause of a non-epileptic event (syncope and reflex anoxic seizures were diagnosed in 42%). 14% of the children were unclassified and managed without a diagnostic label or treatment.[2]
  • They can occur at any age; however, the peak age group is from 6 months to 2 years.[3]
  • Increased vagal tone tends to be familial.
  • During the episode, the child becomes suddenly pale and limp, will fall if standing and loses consciousness.
  • This is followed by stiffening and clonic jerking of the limbs.
  • The episode is usually brief (30-60 seconds) and recovery is rapid.
  • There may also be upward eye deviation and urinary incontinence.
  • On recovery, the child may feel tired and washed-out for some time.
  • Reflex anoxic seizures do not cause tongue-biting and this may be useful in the differentiation from epilepsy.
  • Often diagnosed on the basis of the history and normal electroencephalogram (EEG).
  • ECG: exclude a long QT interval, pre-excitation, heart block or ventricular hypertrophy.
  • Vagal excitation tests, while under continuous EEG and ECG monitoring (ocular compression induces the oculo-cardiac reflex). This procedure is not usually advised or necessary in order to make the diagnosis in children.
  • Reflex anoxic seizures can usually be managed just with reassurance.[4] Drug treatment is rarely, if ever, needed.
  • Parents should be advised to place the child in the recovery position and avoid the natural tendency to pick up the child.
  • Pacemaker insertion is the only definitive treatment and is only used for frequent, severe cases.[5]
  • Apart from pacemaker insertion, most other anti-syncope therapies are ineffective. Valproate and carbamazepine are effective in abolishing anoxic-epileptic seizures but do not influence the frequency of syncope.[6]

Reflex anoxic seizures are benign. The child usually grows out of it.

Further reading and references

  • STARS; Syncope Trust and Reflex Anoxic Seizures

  1. Epilepsies: diagnosis and management; NICE Clinical Guideline (January 2012)

  2. Hindley D, Ali A, Robson C; Diagnoses made in a secondary care "fits, faints, and funny turns" clinic. Arch Dis Child. 2006 Mar91(3):214-8.

  3. McLeod KA; Syncope in childhood. Arch Dis Child. 2003 Apr88(4):350-3.

  4. Wilson D, Moore P, Finucane AK, et al; Cardiac pacing in the management of severe pallid breath-holding attacks. J Paediatr Child Health. 2005 Apr41(4):228-30.

  5. Iyer A, Appleton R; Management of reflex anoxic seizures in children. Arch Dis Child. 2013 Sep98(9):714-7. doi: 10.1136/archdischild-2012-303133. Epub 2013 Jun 28.

  6. Horrocks IA, Nechay A, Stephenson JB, et al; Anoxic-epileptic seizures: observational study of epileptic seizures induced by syncopes. Arch Dis Child. 2005 Dec90(12):1283-7. Epub 2005 Sep 13.

Am I mad!!! I think the nurse don't believe me!! well I cant remember a thing from these and now I may have lost my job due to this!!!! I work within the NHS and have been diagnosed epileptic for...

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