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What's behind the HRT shortage in the UK?

What's behind the HRT shortage in the UK?

Women across the UK are struggling to get hold of their hormone replacement therapy prescriptions due to ongoing manufacturing and supply issues.

Hormone replacement therapy (HRT) is used by around a million women in the UK to improve symptoms of menopause. However, some are currently unable to obtain their prescriptions due to shortages of HRT products.

HRT is used to replace the oestrogen hormones which stop being produced by the ovaries when a woman enters the menopause. Some types also contain the hormone progestogen. HRT treats menopausal symptoms including hot flushes, night sweats, vaginal dryness, sexual function and joint pains. There is some evidence that it can also improve mood and sleep.

The Royal College of Obstetricians and Gynaecologists (RCOG), the British Menopause Society (BMS) and the Faculty of Sexual and Reproductive Healthcare (FSRH) have all received queries from women and doctors who are having issues obtaining HRT, they said in a joint statement. The organisations are calling on the Department of Health and Social Care to work with manufacturers to understand and limit the impact of these shortages.

Professor Lesley Regan, president of the RCOG, stressed the importance of HRT for women who take it for menopausal symptoms. "We are very concerned that thousands of women are struggling to get their HRT prescriptions, or even prescriptions for alternative treatments. HRT is essential for many women to ensure that they are able to continue to lead a high quality life.

"Although we have been told that some of the supply issues are temporary, others are not and are negatively affecting the treatment and care that clinicians can provide to their patients. Most importantly, it means that some women are having to find alternative products or even go without," explained Regan.

The problem is affecting women across the country. "Every week in my clinic I see women who are affected by the shortage in HRT treatment," said President of the FRSH, Dr Asha Kasliwal.

The availability issues are increasing the stress of already difficult symptoms for many menopausal women. "These women are not being able to receive the treatment that best suits their needs, leaving some women to cope with quite debilitating symptoms that directly impact on their daily lives."

How long will the shortage last?

The British Menopause Society is issuing updates on its website about the availability of treatments. Some forms of HRT will be unavailable until the end of August or early September whereas others will be out of stock until mid-2020, according to suppliers. Clinicians are being encouraged to offer alternative treatments with similar levels of hormones to avoid disrupting HRT treatment where possible.

Currently there is little explanation for the shortages beyond manufacturing and supplier issues, although an increased uptake due to awareness of the benefits of HRT may be partially responsible.

Janssen, manufacturer of Evorel HRT treatment, have seen "an unusual increase in demand for HRT over recent months across a number of countries, including the UK", leading to a reduction in the supply of Evorel products. In part, this increased demand was due to shortages of products including Theramex's FemSeven range since the end of 2018, causing women to switch to other brands.

"We need to understand the reasons behind this and what measures could be taken to resolve this issue and to prevent it happening again in the future. It remains unclear why there is a shortage of the treatments in the first place or when the normal supply of the products might resume. We are seeking further information and clarification, as to when the matter will be resolved, from the industry," said Chair of the BMS and consultant gynaecologist, Haitham Hamoda.

"Supplies of alternative HRT products are available and women affected should discuss alternatives with their doctor."

This article has not been peer reviewed by a medical professional but has still been fact-checked and is subject to Patient’s rigorous editorial guidelines. If you have any questions or queries please message the team using the contact link below.
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