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Ancho Chilli Pork Tenderloin with Brussels Sprouts and Squash

This vibrant ancho chilli pork tenderloin is a fantastic example of how diabetes-friendly cooking can be both hearty and sophisticated. The lean pork is rubbed with a smoky, citrus-spiked spice blend and seared to perfection, creating a beautiful crust that seals in the juices. Paired with a colourful medley of roasted brussels sprouts, red onion, and delicata squash, this dish offers a wonderful balance of textures and earthy autumn flavours.

Ideal for a nutritious mid-week meal or a relaxed weekend dinner, the recipe is rounded off with a cooling coriander soured cream that cuts through the mild heat of the ancho chilli. The use of seasonal vegetables ensures a high-fibre accompaniment that complements the protein beautifully. Serve with fresh lime wedges to brighten the savoury notes and enjoy a well-balanced, wholesome plate of food.

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Ingredients for Ancho Chilli Pork Tenderloin with Brussels Sprouts and Squash

  • 2 limes

  • 2 teaspoons ground cumin

  • 1 teaspoon ancho chilli powder

  • 1 teaspoon brown sugar

  • 2 1/4 teaspoons kosher salt, divided

  • 2 pork tenderloins (about 450g each)

  • 675g brussels sprouts, trimmed, quartered

  • 1 large red onion, halved, cut into 1/2-inch-thick wedges

  • 1 delicata squash, halved lengthwise, seeded, sliced into 1/4-inch half moons

  • 60ml vegetable oil, divided

  • 3/4 cup soured cream

  • 1/2 cup coriander, finely chopped, plus whole leaves for serving

  • Flaky sea salt and freshly ground black pepper

Place racks in top and centre of oven; preheat to 218°C. Finely grate 2 teaspoons lime zest into a small bowl. Stir in cumin, chilli powder, brown sugar, and 2 teaspoons salt.

Toss brussels sprouts, onion, squash, 2 tablespoons oil, and half of spiced salt on a rimmed baking sheet. Transfer to centre rack in oven and roast 10 minutes. Toss and continue to roast until vegetables are browned and cooked through, 10–15 minutes more.

Meanwhile, rub pork tenderloins with remaining spiced salt and heat remaining 2 tablespoons oil in a large skillet over medium-high. Sear pork on 3 sides until lightly browned, about 3 minutes per side. Turn tenderloins onto remaining side, then transfer skillet to top rack of oven. Roast pork until an instant-read thermometer inserted into thickest part registers 60°C for medium-rare or 63°C for medium, 8–10 minutes (temperature will rise by about -12°C after cooking). Transfer pork to a cutting board and let rest 5 minutes before slicing.

Whisk soured cream, 2 teaspoons lime juice, 1/2 cup coriander, and remaining 1/4 teaspoons salt in a small bowl. Spoon some sauce onto plates, then arrange pork over. Top with coriander leaves, flakey sea salt, and pepper. Serve vegetables and lime wedges alongside.

Disclaimer

While every effort has been made to ensure the information is accurate and up to date, individual needs may vary and dietary requirements can differ based on personal health conditions. Always check food labels and allergen information before preparing or consuming any recipe. If you have specific health concerns, allergies, intolerances, or are following a medically prescribed diet, seek advice from your GP, pharmacist, or a registered dietitian before making significant changes to your diet or lifestyle.

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UK recipe editors

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UK recipe editors

Article history

The information on this page is peer reviewed by qualified clinicians.

  • 28 Jan 2026 | Originally published

    Authored by:

    UK recipe editors

    Peer reviewed by

    UK recipe editors
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