Needlestick Injury

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PatientPlus articles are written by UK doctors and are based on research evidence, UK and European Guidelines. They are designed for health professionals to use, so you may find the language more technical than the condition leaflets.

Although healthcare workers are those most often affected by needlestick injuries, other occupations can be affected - eg, refuse collectors, cleaners and tattoo artists. Needlestick injuries may also affect carers and children picking up used needles.

The major blood-borne pathogens of concern associated with needlestick injury are hepatitis B virus (HBV), hepatitis C virus (HCV) and HIV. However, other infectious agents also have the potential for transmission through needlestick injury, including:[1]

  • Human T-lymphotropic retroviruses I (HTLV-I) and II (HTLV-II).
  • Hepatitis D virus (HDV - or delta agent) which is activated in the presence of HBV.
  • GB virus C (GBV-C) - formerly known as hepatitis G virus (HGV).
  • Cytomegalovirus (CMV).
  • Epstein-Barr virus (EBV).
  • Parvovirus B19.
  • Transfusion-transmitted virus (TTV).
  • West Nile virus (WNV).
  • Malarial parasites.
  • Prion agents such as those associated with transmissible spongiform encephalopathies (TSEs).

The average estimated seroconversion risks from published studies and reports are:[1]

  • 0.3% for percutaneous exposure to HIV-infected blood.
  • 0.1% for mucocutaneous exposure to HIV-infected blood.
  • 0.5-1.8% for percutaneous exposure to HCV-infected blood with detectable RNA.
  • 30% for percutaneous exposure of a non-immune individual to an HBeAg positive source.

A Health Protection Agency (HPA) report regarding healthcare workers, released in 2012, stated that:[2]

  • Between 2002 and 2011, 4,381 significant occupational exposures were reported (increasing from 276 in 2002 to 541 in 2011).
  • Between 2008 and 2011, there were 5 HCV hospital-acquired transmissions from patients to healthcare workers following percutaneous exposure injuries; 3 reported from England and 2 in Scotland.
  • Even though percutaneous injuries remain the most commonly reported occupational exposures in the healthcare setting, they have decreased over time as a percentage of all exposures (from 79% in 2002 to 67% in 2011), whilst mucocutaneous exposures have shown an increase (from 21% in 2002 to 29% in 2011).
  • The percentage of healthcare workers reporting percutaneous exposures that involved an HCV infected source patient declined from 38% in 2002 to 32% in 2011.
  • Between 2002 and 2011 most occupational exposures involved nursing professions. Medical and dental professions reported a similar number of occupational exposures as nursing professions in 2011, with exposures in medical and dental professions increasing by 131% (100 to 231) between 2002 and 2011.
  • 72 significant occupational exposures reported between 2002 and 2011 involved ancillary staff. The majority of these exposures were due to non-compliance with standard infection control precautions for the handling and safe disposal of clinical waste.
  • The total number of HCV seroconversions in healthcare workers reported between 1997 and 2011 is 20; 17 cases reported in England and 3 in Scotland.
  • The last case of an HIV seroconversion in an occupationally exposed healthcare worker was reported in 1999.

Certain features of a percutaneous injury carry a particularly high risk:[3]

  • A deep injury.
  • Terminal HIV-related illness in the source patient.
  • Visible blood on the device which caused the injury.
  • Injury with a needle which had been placed in a source patient's artery or vein.

In one study of 98 UK surgeons in a large district general hospital, 44% anonymously admitted to having a needlestick injury. The study concluded that the incidence of such injuries was likely to be under-reported, particularly in the surgical sector.[4]

Follow local or national or international protocol.[5][6] The study of surgeons in a district general hospital found that only 3% followed agreed local policy, and promotion of the importance of safety procedures needed to be emphasised.[4]

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First aid

  • Contaminated needlestick, sharps injury, bite or scratch - encourage bleeding, wash with soap and running water.
  • Blood or body fluid in the eyes or mouth - irrigate with copious quantities of cold water.
  • Blood or body fluid on broken skin - encourage bleeding if possible and wash with soap under running water (but without scrubbing).

Report the incident and discuss with a local public health consultant immediately

Discuss type of injury, donor HIV status if known, etc. In the case of definite exposures to blood or other high-risk body fluids known or considered to be at high risk of HIV infection, post-exposure prophylaxis (PEP) should be offered as soon as possible, preferably within one hour of the incident. It may still be worth considering up to 72 hours after the exposure, but the relative benefit of prophylaxis diminishes with time. The current standard recommended regimen for PEP is a 28-day course of:[1]

  • Truvada® (tenofovir disoproxil 245 mg/emtricitabine 200 mg) one tablet twice a day, plus
  • Kaletra® (lopinavir 200 mg/ritonavir 50 mg) two tablets twice daily.

See also the separate article HIV Post-exposure Prophylaxis. Antiretroviral drugs are not licensed for PEP, so must be prescribed on a 'named patient' basis by a doctor..

Hepatitis B vaccine and immunoglobulin: see the separate article on Hepatitis B Vaccination and Prevention.

The exposed person should also be advised to have safe sex for three months, not to donate blood until all necessary screening tests are clear, and to see their GP if they develop a fever.


  • Take blood for virology, (HIV, hepatitis B, hepatitis C) from the injured person. Start PEP where appropriate and consider the need for antibiotic therapy or hepatitis B immunisation. Recheck HIV status three months later and hepatitis serology three and six months later.
  • LFTs should be performed and repeated at three and six months.
  • Female workers should have a beta-hCG check to exclude pregnancy.
  • It can be very helpful to test source patients, with their informed consent, for HIV, HBV and HCV, regardless of risk factors, unless very recent results are available:


Fill out the accident book and the complete critical event audit. Consider carefully how subsequent events can be prevented.


Ensure there is adequate follow-up of both care worker and donor. The care worker in particular will require early involvement by the occupational health service. They may need specific advice on having to take sick leave if medication is required and the possible requirement for psychological support.

This is of prime importance. The HPA advises the following:[6]

General measures

  • Wash hands before and after contact with each patient and before putting on and after removing gloves.
  • Change gloves between patients.
  • Cover with waterproof dressings any existing wounds, skin lesions and all breaks in exposed skin, and wear gloves if hands are extensively affected.
  • Wear gloves where contact with blood can be anticipated.
  • Avoid sharps usage where possible and, where sharps usage is essential, exercise particular care in handling and disposal.
  • Avoid wearing open footwear in situations where blood may be spilt, or where sharp instruments or needles are handled.
  • Clear up spillage of blood promptly and disinfect surfaces.
  • Pre-employment occupational health assessment should identify those with damaged skin - eg, fissured hand eczema, who may be at higher risk of occupationally acquired infection and ensure that advice is given about minimising any occupational health risk to which they may be exposed.
  • Wear gloves when cleaning equipment prior to sterilisation or disinfection, when handling chemical disinfectant and when cleaning up spillages.
  • Follow safe procedures for disposal of contaminated waste.

Specific measures

This will obviously depend on the procedure being undertaken but may include:

  • Use of new, single-use disposable injection equipment for all injections is highly recommended. Sterilisable injection should only be considered if single use equipment is not available and if the sterility can be documented with Time, Steam and Temperature indicators.
  • Discard contaminated sharps immediately and without recapping in puncture- and liquid-proof containers that are closed, sealed and destroyed before completely full.
  • Document the quality of the sterilisation for all medical equipment used for percutaneous procedures.
  • Wash hands with soap and water before and after procedures; use protective barriers such as gloves, gowns, aprons, masks, and goggles for direct contact with blood and other body fluids.
  • Disinfect instruments and other contaminated equipment.
  • Handle soiled linen properly. (Soiled linen should be handled as little as possible. Gloves and leakproof bags should be used if necessary. Cleaning should occur outside patient areas, using detergent and hot water.)

National Institute for Health and Clinical Excellence (NICE) recommendations[7] 

  • Safe use and disposal of sharps:
    • Sharps should not be passed directly from hand to hand, and handling should be kept to a minimum.
    • Used needles must not be bent or broken before disposal, and must not be recapped.
    • Used sharps must be discarded immediately by the person generating the sharps waste into a sharps container conforming to current standards.
  • Sharps containers:
    • Must be located in a safe position that avoids spillage, is at a height that allows the safe disposal of sharps, is away from public access areas and is out of the reach of children.
    • Must not be used for any other purpose than the disposal of sharps.
    • Must not be filled above the fill line.
    • Must be disposed of when the fill line is reached.
    • Should be temporarily closed when not in use.
    • Should be disposed of every three months even if not full, by the licensed route in accordance with local policy.
  • Use sharps safety devices if a risk assessment has indicated that they will provide safer systems of working for healthcare workers, carers and patients.
  • Train and assess all users in the correct use and disposal of sharps and sharps safety devices.

More detailed advice, including use of blunt-tipped needles, and 'neutral zones' for passing of sharps during surgery, are available in 'Guidance for Clinical Health Care Workers' in 'Further reading & references', below.[8]

Guidance for NHS employers (who are now under a statutory obligation to prevent and control spread of healthcare-associated infection) can be found on the NHS Employers' website.[1]

Further reading & references

  1. Needlestick Injury; NHS Employers
  2. Eye of the Needle: 2012, Health Protection Agency
  3. Blood safety and HIV, AVERT - Averting HIV and AIDS
  4. Thomas WJ, Murray JR; The incidence and reporting rates of needle-stick injury amongst UK surgeons. Ann R Coll Surg Engl. 2009 Jan;91(1):12-7. Epub 2008 Nov 4.
  5. HIV post-exposure prophylaxis - guidance from the UK Chief Medical Officers' Expert Advisory Group on AIDS; Dept of Health, 2008
  6. Strategy to protect health workers from infection from bloodborne viruses; World Health Organization
  7. Healthcare-associated infections: prevention and control in primary and community care; NICE Clinical Guideline (March 2012)
  8. Guidance for Health Care Workers: Protection Against Infection with Blood-borne Viruses, Dept of Health

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Dr Laurence Knott
Current Version:
Peer Reviewer:
Prof Cathy Jackson
Document ID:
2497 (v24)
Last Checked:
Next Review:

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