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Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Epiglottitis article more useful, or one of our other health articles.

Synonym: supraglottitis

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What is epiglottitis?

Epiglottitis is a life-threatening condition and a high index of suspicion is required. Any patients, of any age, with a severe sore throat, not tolerating oral fluids, should be referred for urgent assessment.

Acute epiglottitis is a condition in which there is inflammation of the epiglottis. It may also affect the soft tissues surrounding the epiglottis, particularly in affected adults - hence the term supraglottitis1 . It is potentially life-threatening if complete obstruction of the airway occurs.


  • Epiglottitis is rare, affecting 1-4/100,000 population1 .

  • Since the widespread introduction of Haemophilus Influenza type B (Hib) vaccination, acute epiglottitis is now extremely rare in children2 .

  • Some studies suggest an increased prevalence in adults, thought to be related to miscellaneous pathogenic bacteria3 ,

  • The usual age of presentation in children is 2-5 years. Adults present in their 40s and 50s and it affects more men than women4 .

  • Adults who develop epiglottitis are more likely to have other underlying medical conditions that affect their immunity either systemically or locally5 .

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Epiglottitis causes (aetiology)4

  • In a series of 308 epiglottitis patients, the causative organism in the majority of cases was Streptococcus spp.5 .

  • Other bacterial causes include Staphylococcus aureus, Haemophilus influenzae type b (Hib), Pseudomonas spp., Moraxella catarrhalis and Mycobacterium tuberculosis.

  • Viruses include herpes simplex virus, with bacterial superinfection.

  • Candida spp. and Aspergillus spp. in immunocompromised patients.

  • Non-infectious causes of epiglottitis reported include thermal causes (eg, steam, crack cocaine smoking), caustic insults (eg, dishwasher pellets), foreign bodies and trauma, including traditional Chinese gua sha therapy6 .

  • Reactive epiglottitis may also occur as a reaction to head and neck chemotherapy.

Epiglottitis symptoms

Many of the signs and symptoms associated with acute epiglottitis are common and may occur in many less serious disorders. Patients with epiglottitis may present with any of the following and the symptoms may evolve very quickly over a period of a few hours7 .

The most common epiglottitis symptoms

  • Sore throat.

  • Odynophagia (painful swallowing).

  • Inability to swallow secretions (drooling in children).

  • Muffled voice - 'hot potato' voice.

  • Fever.

Other epiglottitis symptoms

  • High temperature.

  • Tachycardia.

  • Anterior neck tenderness over the hyoid bone8 .

  • Ear pain.

  • Cervical lymphadenopathy.

  • The 'tripod sign' - the patient leans forward on outstretched arms to move inflamed structures forward, thereby easing the upper airway obstruction9 .

With more severe epiglottitis

  • Dyspnoea.

  • Dysphagia.

  • Dysphonia.

  • Respiratory distress.

  • Stridor - is a sign of upper airways obstruction and is a surgical emergency.

Diagnosis in adults can be difficult, as they may not have signs of respiratory distress (stridor). Patients with a significant sore throat with no obvious aetiology should be referred to ENT for direct visualisation of their larynx by flexible laryngoscopy. More than 90% of epiglottitis patients will have a normal oropharyngeal cavity and the diagnosis should be suspected when the severity of the epiglottitis symptoms does not correlate with the findings on examination4 .

Children with epiglottitis rarely have a cough, which may help to distinguish it from laryngotracheobronchitis or 'croup'4 .

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Differential diagnosis

The differential diagnosis will depend on the presenting epiglottitis symptoms and age of the patient; however, generally included are:


Patients who are suspected of having acute epiglottitis should not have their throat examined with the aid of a tongue depressor, due to the risk of laryngeal obstruction; rather, they should be urgently referred for laryngoscopy.

  • Fibre-optic laryngoscopy remains the 'gold standard' for diagnosing epiglottitis, as the epiglottis can be seen directly. Laryngoscopy in these patients should only be performed in areas such as operating theatres which are prepared for intubation or tracheostomy in the event of upper airway obstruction.

  • Lateral neck X-ray may be useful if laryngoscopy is not possible. Soft-tissue radiograph of the neck may show the 'thumbprint sign'10 .

  • Throat swabs may be taken when the airway is secure, or when intubation/tracheostomy facilities are at hand.

  • Blood cultures may be taken if the patient is systemically unwell.

  • CT or MRI scans may be performed if abscess formation is suspected.

Epiglottitis treatment and management

  • Initial presentation may resemble a viral sore throat, so a high index of suspicion is needed. Emergency referral is required if signs of airway obstruction are present (stridor). Deterioration in symptoms may be rapid, especially in children.

  • Management is usually conservative with intravenous or oral antibiotics but intubation may be needed .

  • Surgical tracheostomy may be required in patients with severe airway obstruction in whom intubation has not been possible.

  • Abscess formation is increasing in incidence. This may partly be explained by advances in imaging (CT and MRI)11 . Drainage may be required in some patients.


Epiglottitis, if not adequately treated, may occasionally result in:


The great majority of patients with epiglottitis will make a complete recovery with no sequelae. Early diagnosis appears to reduce the need for intubation which, in a series of over 300 cases, was required in only 15%5 . Outcomes are generally good for adults, with fewer cases needing intubation than among children12 . However, death may occur rapidly if the condition is not recognised and complete airway obstruction occurs.

Epiglottitis prevention

Hib vaccination has dramatically reduced the incidence of acute epiglottitis in children in those countries in which the vaccination is included in the routine vaccination protocol for children.

Further reading and references

  1. Hermansen MN, Schmidt JH, Krug AH, et al; Low incidence of children with acute epiglottis after introduction of vaccination. Dan Med J. 2014 Apr;61(4):A4788.
  2. Guardiani E, Bliss M, Harley E; Supraglottitis in the era following widespread immunization against Haemophilus influenzae type B: evolving principles in diagnosis and management. Laryngoscope. 2010 Nov;120(11):2183-8. doi: 10.1002/lary.21083.
  3. Abdallah C; Acute epiglottitis: Trends, diagnosis and management. Saudi J Anaesth. 2012 Jul;6(3):279-81. doi: 10.4103/1658-354X.101222.
  4. Glynn F, Fenton JE; Diagnosis and management of supraglottitis (epiglottitis). Curr Infect Dis Rep. 2008 May;10(3):200-4.
  5. Bizaki AJ, Numminen J, Vasama JP, et al; Acute supraglottitis in adults in Finland: review and analysis of 308 cases. Laryngoscope. 2011 Oct;121(10):2107-13. doi: 10.1002/lary.22147. Epub 2011 Sep 6.
  6. Tsai KK, Wang CH; Acute epiglottitis following traditional Chinese gua sha therapy. CMAJ. 2014 May 13;186(8):E298. doi: 10.1503/cmaj.130919. Epub 2013 Nov 25.
  7. Parsons DS, Smith RB, Mair EA, et al; Unique case presentations of acute epiglottic swelling and a protocol for acute airway compromise. Laryngoscope. 1996 Oct;106(10):1287-91.
  8. Al-Qudah M, Shetty S, Alomari M, et al; Acute adult supraglottitis: current management and treatment. South Med J. 2010 Aug;103(8):800-4.
  9. Kudchadkar SR, Hamrick JT, Mai CL, et al; The heat is on... thermal epiglottitis as a late presentation of airway steam injury. J Emerg Med. 2014 Feb;46(2):e43-6. doi: 10.1016/j.jemermed.2013.08.033. Epub 2013 Oct 7.
  10. Tan CK, Chan KS, Cheng KC; Adult epiglottitis. CMAJ. 2007 Feb 27;176(5):620.
  11. Hindy J, Novoa R, Slovik Y, et al; Epiglottic abscess as a complication of acute epiglottitis. Am J Otolaryngol. 2013 Jul-Aug;34(4):362-5. doi: 10.1016/j.amjoto.2013.01.003. Epub 2013 Feb 5.
  12. Price IM, Preyra I, Fernandes CM, et al; Adult epiglottitis: a five-year retrospective chart review in a major urban centre. CJEM. 2005 Nov;7(6):387-90.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

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