Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines, so you may find the language more technical than the condition leaflets.
There are several equations available for estimating GFR.
This calculator uses the abbreviated MDRD equation (MDRD = Modification of Diet in Renal Disease Study), which is the one recommended by NICE and The Renal Association (UK). See the accompanying clinical record Assessing Kidney Function.
The calculator is based on the equation described in Levey AS, Bosch JP, Lewis JB, et al; A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999 Mar 16;130(6):461-70.
Use the eGFR value calculated by your local laboratory in preference to the above as it is likely to be more accurate (as it may adjust for variations in creatinine measurements). Calculator above uses the abbreviated MDRD equation: Estimated GFR (ml/min/1.73m2) = 186 x (Creat / 88.4)-1.154 x (Age)-0.203 x (0.742 if female) x (1.210 if black)
Stages of Chronic Kidney Disease
Use the suffix (p) to denote the presence of proteinuria when staging chronic kidney disease (CKD).
|Stage||Glomerular Filtration Rate|
Values are normalised to an average surface area (size) of 1.73 m2
|I||90+||Normal renal function (but urinalysis, structural abnormalities or genetic factors indicate renal disease).||Observation and control of blood pressure.|
|II||60-89||Mildly reduced renal function|
(Stage 2 CKD should not be diagnosed on GFR alone - but urinalysis, structural abnormalities or genetic factors indicate renal disease.)
|Observation, control of blood pressure and cardiovascular risk factors.|
|IIIa||45-59||Moderate decrease in renal function, with or without other evidence of kidney damage.||Observation, control of blood pressure and cardiovascular risk factors.|
|IIIb||30-44||Moderate decrease in renal function, with or without other evidence of kidney damage.||Observation, control of blood pressure and cardiovascular risk factors.|
|IV||15-29||Severely reduced renal function.||Planning for end-stage kidney disease.|
|V||<15||Very severe (end-stage) kidney disease.||Transplant or dialysis.|
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