Professional Reference articles are written by UK doctors and are based on research evidence, UK and European Guidelines. They are designed for health professionals to use, so you may find the language more technical than the condition leaflets.
Synonym: Zenker's diverticulum
A pharyngeal pouch represents a posteromedial pulsion diverticulum through Killian's dehiscence. It is a herniation between the thyropharyngeus and cricopharyngeus muscles that are both part of the inferior constrictor of the pharynx.
The aetiology is unknown.However, malfunction of the upper oesophageal sphincter probably contributes. A diagrammatic representation of the anatomy can be found in the Surgical Tutor reference.
It is uncommon but the incidence appears to be higher in Northern Europe than elsewhere.It is largely confined to those aged over 70 years and males outnumber females by 5:1.
The usual presenting features are dysphagia, regurgitation, aspiration, chronic cough and weight loss. Usually there are no clinical signs but there may be a lump in the neck that gurgles on palpation. There may also be halitosis from food decaying in the pouch.
Endoscopy should be avoided as an initial investigation for fear of perforating the lesion. A barium swallow may show a residual pool of contrast within the pouch.
Indirect laryngoscopy may show a pooling of saliva within the pyriform fossa.
This is dependent upon the size of the pouch. With recognition of the importance of the cricopharyngeus muscle in the pathogenesis of the pouch, the emphasis on treatment has shifted from diverticulectomy to cricopharyngeal myotomy. Minimally invasive techniques have become established with endoscopic stapling devices. There is no clear evidence whether one endoscopic procedure is superior to another.
This is used for larger lesions. A rigid endoscope is passed and the pouch is packed with gauze. An incision is made at the level of the cricoid cartilage and the fascia at the anterior border of the sternomastoid is divided. The pouch is identified and excised and the defect closed. Cricopharyngeal myotomy is performed to prevent recurrence. The patient is fed via a nasogastric tube for a week postoperatively. Potential complications include:
- Recurrent laryngeal nerve palsy.
- Cervical emphysema.
- Cutaneous fistula.
This is suitable for smaller lesions and is performed via an endoscope. A double-lipped oesophagoscope is used and the wall between the diverticulum and oesophageal wall is exposed. The hypopharyngeal bar is divided with diathermy or laser.
The advantages are that it is a minimally invasive technique that allows:
- Shorter duration of anaesthesia.
- More rapid resumption of oral intake.
- Shorter hospital stay.
- Quicker recovery.
There is no evidence from high-quality randomised controlled trials to demonstrate the effectiveness of endoscopic compared with open procedures for pharyngeal pouch. There is no good evidence to establish whether one endoscopic procedure is superior to another. There is some evidence that, whilst endoscopic surgery is safer for the elderly and frail, there may be a higher rate of recurrence and the conversion to an open procedure may be required if there are technical difficulties or perforation during operation.
- Aspiration from the pouch can cause inhalation pneumonia.
- Carcinoma may develop in the pouch, although the true level of risk is debated.
Friedrich Albert von Zenker was a German physician and pathologist. He was born in Dresden in 1825 and died in 1898. He studied at Leipzig and received his doctorate in 1851. His name is also attached to Zenker's degeneration: severe glassy or waxy hyaline degeneration or necrosis of skeletal muscles in acute infectious diseases, and to Zenker's paralysis: peroneal nerve palsy.
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Further reading & references
- Friedrich Albert von Zenker; whonamedit.com
- Flexible endoscopic treatment of a pharyngeal pouch; NICE Interventional Procedure Guidance, February 2015
- Sen P, Kumar G, Bhattacharyya AK; Pharyngeal pouch: associations and complications. Eur Arch Otorhinolaryngol. 2006 Feb 4
- Pharyngeal pouch; Surgical Tutor
- Bizzotto A, Iacopini F, Landi R, et al; Zenker's diverticulum: exploring treatment options. Acta Otorhinolaryngol Ital. 2013 Aug 33(4):219-29.
- Siddiq MA, Sood S, Strachan D; Pharyngeal pouch (Zenker's diverticulum). Postgrad Med J. 2001 Aug
- Aly A, Devitt PG, Jamieson GG; Evolution of surgical treatment for pharyngeal pouch. Br J Surg. 2004 Jun
- Sen P, Lowe DA, Farnan T; Surgical interventions for pharyngeal pouch. Cochrane Database Syst Rev. 2005 Jul 20
- Endoscopic stapling of pharyngeal pouch; NICE Interventional Procedures Guidance, November 2003
- Sen P, Bhattacharyya AK; Endoscopic stapling of pharyngeal pouch. J Laryngol Otol. 2004 Aug
- Mirza S, Dutt SN, Minhas SS, et al; A retrospective review of pharyngeal pouch surgery in 56 patients. Ann R Coll Surg Engl. 2002 Jul
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