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Treatment of almost all medical conditions has been affected by the COVID-19 pandemic. NICE has issued rapid update guidelines in relation to many of these. This guidance is changing frequently. Please visit https://www.nice.org.uk/covid-19 to see if there is temporary guidance issued by NICE in relation to the management of this condition, which may vary from the information given below.
Synonyms: orgasmic cephalgia, orgasmic headache, sexual headache, coital headache, early coital cephalgia, orgasmic coital cephalgia
Primary sexual headache is headache associated with sexual activity. The exact prevalence in not known, although it is more common in women than in men. There are two types - pre-orgasmic and orgasmic headache. The latter is most significant because of its similarity to significant causes of secondary headache including subarachnoid haemorrhage (and warning bleeds for subarachnoid haemorrhage) and reversible cerebral vasoconstriction syndromes. Neuroimaging is needed to distinguish primary, benign causes of sexual headache from secondary, potentially life-threatening causes.
Primary sexual headache is included in the list of 'Other Primary Headaches', which is the fourth group of primary headaches in the International Classification of Headache Disorders (the other three being tension-type headache, migraine and cluster headaches).
Several theories have been put forth to explain the underlying mechanism of primary sexual headache. The leading explanation involves exertion leading to a sudden increase in intracranial pressure or an inappropriate reaction in the cerebral vasculature. Neural hypersensitivity, similar to migraine, may also play a role.
Headaches provoked by cough and exertion share some features with primary sexual headache, although they affect different age groups and have different gender distributions. Valsalva-like manoeuvres are the common triggers. Migraine is commonly comorbid with exertion headaches and coital headaches, and some patients with coital headache may have reversible cerebral vasoconstriction syndromes.
Whilst most headaches relating to sexual activity are benign, a few are associated with significant morbidity ('malignant coital cephalgia'):
- Some patients have reversible cerebral vasoconstriction syndromes.[4, 5]
- Subarachnoid bleeding may be precipitated by coitus in patients with berry aneurysms and arteriovenous malformations (one study suggested that 3-12% of berry aneurysms and 4% of arteriovenous malformations might rupture in this way, although in the case of berry aneurysms the risk of rupture is also related to size and other factors).
- Basilar artery dissection presenting as thunderclap headache with orgasm has been reported.
There are two subtypes of primary sexual headache:
- Early coital cephalgia, usually of short duration and moderately severe. It is a tight, cramping, dull pain, often bilateral in the occipital/cervical region, which intensifies as sexual excitement increases. It is associated with an awareness of neck or jaw muscle contraction. It is thought to relate to excessive contraction of the head and neck musculature that occurs prior to orgasm.
- Orgasmic coital cephalgia, which is severe, comes on abruptly and typically lasts 15 to 20 minutes. It can be in the occipital region, behind the eyes, or in a more generalised form and occurs at the point of orgasm. It may be prevented by postponing orgasm. It is the most common type of headache associated with sexual activity. On the first occasion, at least, it is mandatory to exclude serious causes of sudden-onset headache, including subarachnoid haemorrhage and arterial dissection.
In addition, a secondary headache called late coital cephalgia has been associated with sexual activity. It is, however considered to be a secondary headache attributed to spontaneous or idiopathic low CSF pressure and is coded under secondary headache. It comes on after intercourse, on standing and may last for hours or days. It is believed to be caused by low CSF pressure secondary to a dural tear following the physiological stress of coitus and is identical to the headache seen after lumbar puncture.
Primary sexual headache is not usually recurrent:
- It may appear suddenly, last for many months or years and stop abruptly
- It may occasionally occur on a regular basis for several months or, rarely, years.
- Attacks may be intermittent and mild, or so severe as to preclude coitus.
- Amnesia has been described as a rare association. This is generally benign and self-limiting but clearly requires investigation.
Little is known about the incidence but studies of neurological patients presenting with headache in France and Denmark have quoted figures of up to 1.3% of presenting headaches.
- There is a 3:1 predominance of males.
- The age of onset peaks between 20-24 years and again between 35-44 years.
- It is rare in children but a case in a boy of 12 has been reported.
- There appears to be a high comorbidity with migraine, benign exertional headache and tension-type headache.
- Occurrence is not dependent on specific sexual habits. It most often occurs during sexual activity with the usual partner but also occurs during masturbation.
These include obesity, kneeling position during intercourse, the degree of sexual excitement, stress, history of migraine and exertion headache and a family history of headache and occlusive arterial disease. A case of familial sexual headache has been reported.
Pharmacological triggers may include marijuana, amyl nitrite, amfetamines, sildenafil and some anxiolytics.
The likely diagnosis of benign coital cephalgia may seem clear from the history - but it must be one of exclusion, having ruled out subarachnoid bleeding. This is particularly the case on the first occurrence. Lack of accompanying symptoms such as vomiting or visual, sensory, or motor disturbance is reassuring (but not completely so). Sudden-onset ('thunderclap') headaches represent subarachnoid haemorrhage even in the absence of associated symptoms in 1 in 10 cases.
Careful history and examination are essential, but neuroimaging is often required and there should be a low threshold for doing this. Among patients with SAH who initially present in good condition, misdiagnosis is associated with increased mortality and morbidity.[1, 13]
National Institute for Health and Care Excellence (NICE) guidance recommends evaluation for further investigation in people who present with any of the following, which includes most primary sexual headaches:
- Sudden-onset headache reaching maximum intensity within five minutes
- Seadaches triggered by cough, sneeze or Valsalva manoeuvre.
- Headaches triggered by exercise.[7, 14]
Some authors go further and suggest that - particularly on first occurrence, CT is insufficient and the CSF should be examined, particularly if presentation is more than two days after the event.
Weight reduction, increase in exercise, taking the passive role in intercourse and avoidance of drugs which act as trigger factors are all thought to be helpful.
The primary treatment is usually reassurance as the headaches are not usually recurrent. Drug management can be offered. Indometacin and propranolol are the most established and evidenced treatments but all of the following are supported by randomised trials or case reports:
- Propranolol - 40-240 mg a day. This can be used on a preventative basis.[16, 17]
- Indometacin - 25-75 mg a day can be used on an intermittent or regular basis.[4, 16]
- Topiramate (50 g daily) has been successfully used as prophylaxis in patients in whom the above two drugs were contra-indicated.
- Calcium-channel blockers (eg, diltiazem 60 mg tds, nimodipine) have been helpful in some patients, particularly where cerebral vasoconstriction is the probable cause.[18, 19]
- One study reported a role for triptans, both in the acute phase and in prophylaxis of headache associated with sexual activity.
Many patients will experience only one episode but the condition may be recurrent. In one study, out of 45 patients who had experienced single attacks or bouts prior to baseline examination, 37 had no further attacks. Seven patients experienced at least one further bout with an average duration of 2.1 months. One patient developed a chronic course of the disease after an episodic start. In 69% of patients experiencing recurrent primary sexual headaches the condition resolved completely over three years.
Further reading and references
International Headache Society Classification of Headaches ICHD II; Updated Web-based Version
Frese A, Eikermann A, Frese K, et al; Headache associated with sexual activity: demography, clinical features, and comorbidity. Neurology. 2003 Sep 2361(6):796-800.
Lane JC, Gulevich S; Exertional, Cough, and Sexual Headaches. Curr Treat Options Neurol. 2002 Sep4(5):375-381.
Wang SJ, Fuh JL; The "other" headaches: primary cough, exertion, sex, and primary stabbing Curr Pain Headache Rep. 2010 Feb14(1):41-6.
Montague E, Murphy C; Reversible Cerebral Vasoconstriction Syndrome: an important cause of thunderclap headache. Acute Med. 201413(2):74-6.
Delasobera BE, Osborn SR, Davis JE; Thunderclap Headache with Orgasm: A Case of Basilar Artery Dissection Associated J Emerg Med. 2009 Oct 7.
Headaches in over 12s: diagnosis and management; NICE Clinical Guideline (September 2012, updated November 2015)
Diener HC, Johansson U, Dodick DW; Headache attributed to non-vascular intracranial disorder. Handb Clin Neurol. 201097:547-87. doi: 10.1016/S0072-9752(10)97050-4.
Larner AJ; Transient acute neurologic sequelae of sexual activity: headache and amnesia. J Sex Med. 2008 Feb5(2):284-8. Epub 2007 Dec 7.
Evers S, Peikert A, Frese A; Sexual headache in young adolescence: a case report. Headache. 2009 Sep49(8):1234-5. Epub 2009 Jul 27.
Johns DR; Benign sexual headache within a family. Arch Neurol. 1986 Nov43(11):1158-60.
Alvaro LC, Iriondo I, Villaverde FJ; Sexual headache and stroke in a heavy cannabis smoker. Headache. 2002 Mar42(3):224-6.
Kowalski RG, Claassen J, Kreiter KT et al; Initial Misdiagnosis and Outcome After Subarachnoid Hemorrhage, Journal of the American Medical Association February 18, 2004, Vol 291, No. 7.
Headaches in young people and adults; NICE Quality Standards, Aug 2013
Du L, Yang Y, Wu J, et al; Orgasmic headache treated with nimodipine. J Sex Med. 2014 Jan11(1):311. doi: 10.1111/jsm.12328. Epub 2013 Sep 25.
Domitrz I; [Primary headache associated with sexual activity]. Ginekol Pol. 2005 Dec76(12):995-9.
Goldstein J; Sexual aspects of headache. How sexual function relates to headaches and their causes and treatment. Postgrad Med. 2001 Jan109(1):81-4, 87-8, 92.
Lee JW, Ha YS, Park SC, Seo IY, and Lee HS; Orgasmic headache treated with nimodipine. J Sex Med 201310:1893–1896.
Theeler BJ, Krasnokutsky MV, Scott BR; Exertional reversible cerebral vasoconstriction responsive to verapamil. Neurol Sci. 2010 Feb 25.
Frese A, Gantenbein A, Marziniak M, et al; Triptans in orgasmic headache. Cephalalgia. 2006 Dec26(12):1458-61.
Frese A, Rahmann A, Gregor N, et al; Headache associated with sexual activity: prognosis and treatment options. Cephalalgia. 2007 Nov27(11):1265-70. Epub 2007 Oct 5.