Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Scabies article more useful, or one of our other health articles.
Treatment of almost all medical conditions has been affected by the COVID-19 pandemic. NICE has issued rapid update guidelines in relation to many of these. This guidance is changing frequently. Please visit https://www.nice.org.uk/covid-19 to see if there is temporary guidance issued by NICE in relation to the management of this condition, which may vary from the information given below.
Scabies is an itchy rash caused by the parasitic mite Sarcoptes scabiei. Scabies has caused pruritic infestation in humans for over 2,500 years, at least back to the Roman period. The Romans used 'scabies' to describe any itchy skin disease. The word scabies is derived from the Latin word 'scabere', meaning 'to scratch'. The mite was identified in the 17th century, and described by an Italian physician, Giovanni Cosimo Bonomo, making it one of the first diseases to have a known cause.
It is often difficult to diagnose due to the spectrum of associated signs and symptoms and its clinical mimicry of other conditions.
Globally it is an enormous public health problem, causing significant morbidity and mortality in developing countries, and a feeling that it has been neglected prompted the formation of the International Alliance for the Control of Scabies (IACS). There are also concerns about increasing resistance to drugs currently available.
The female scabies mite is about 0.4 mm long, and the male is about half this size. After mating on the skin surface, the male dies and the female mite tunnels into the epidermis, and deposits eggs along the burrow. Development from egg to adult takes about 10-15 days. Adult mites then return to the skin surface to multiply. Mites die after 4-6 weeks.
An average host harbours 10-12 mites, but this may be greatly increased in immunocompromised patients. Female mites can move at up to 2.5 cm per minute but they do not jump or fly. It usually requires skin contact of 10-15 minutes for mites to be passed from one host to another. Classical scabies is usually transmitted only via direct skin contact. Crusted scabies (a more severe variety, see below) can also be transmitted via bedding, towels, clothes and furniture.
There is a period of asymptomatic infection. Pruritus develops as an allergic reaction to infection, around 4-6 weeks after infestation. Infection can be transmitted to others during the asymptomatic phase. Therefore a high index of clinical suspicion for scabies is needed.
- Poverty, poor nutritional status.
- Poor hygiene.
- Institutions. Residential care homes in the UK, refugee camps in some parts of the world.
- Sexual contact.
- Children, especially in developing countries.
- Immune suppression (eg, HIV infection). Like the elderly, immunocompromised individuals are at particular risk of the crusted variant. They tend to present with clinically atypical lesions and are often misdiagnosed, causing a delay in appropriate treatment and increased risk of a local epidemic.
Scabies is one of the most common skin diseases worldwide, affecting 150-200 million people yearly. Scabies affects young children in particular, and has the greatest impact in poor overcrowded living conditions.
A UK study estimated the overall prevalence of scabies to be 2.81 per 1,000 females and 2.27 per 1,000 males. In the UK, an epidemic cycle with a length of 15–17 years has been noted.
Scabies is most common in females, in people aged 10-19 years, in areas with high levels of social deprivation, and during winter.
In the UK, outbreaks may occur in residential or nursing homes, hospitals, prisons and occasionally in schools. Delayed diagnosis significantly contributes to outbreaks. In other parts of the world, those in overcrowded situations such as refugee camps are particularly at risk. Prevalence is strongly associated with overcrowding and poverty.
Scabies can be difficult to diagnose as examination findings can be subtle. Important clues include severe pruritus that is worse at night, close contacts who have similar symptoms, and a history of exposure. Examination findings include white lines, indicative of the mite burrowing, which classically occur in the interdigital web spaces, the areolae of female breasts, or the male genitalia, but may be found on other body sites.
- In primary infestation, signs and symptoms only develop after 3-6 weeks. Infected contacts may be asymptomatic for up to a month which is why empirical treatment of all significant contacts is suggested. Symptoms reappear within 1-3 days if the person is re-infested due to prior sensitisation.
- The most common presenting symptom is widespread itching. This is usually worse at night and when the person is warm. A history of several family members all suffering with itch is strongly suggestive of scabies. Scratching predisposes to secondary bacterial infection.
- On examination the skin changes vary. Lesions may be papules, vesicles, pustules, and nodules. Erythematous papular or vesicular lesions are usually seen in the sites of the burrows. The more widespread, symmetrical, itchy, papular eruption is not in the areas of burrows or obvious mite activity. This is most commonly seen around the axillae, the peri-areolar region of the breasts in women, and the abdomen, buttocks and thighs. Excoriation marks are common and may be more marked than the underlying rash.
By Gzzz (Own work), CC BY-SA 4.0, via Wikimedia Commons
- Burrows may be visible as fine, wavy, greyish, dark or silvery lines, 2-15 mm long, sometimes with a minute speck (the mite) at the closed end. They are most often seen in the interdigital web spaces of the hands, flexor surfaces of the wrists and elbows, axillae, ankles, feet, buttock areas, male genitalia and peri-areolar area in women.
By Steschke (Own work), CC BY-SA 3.0, via Wikimedia Commons
- Some authorities describe the 'wake' sign: scabies burrows are followed by a pattern of scale similar to the 'wake' left on the surface of water by a moving bird or a boat. The 'wake' sign is specific for scabies, can be seen with the naked eye and points towards the location of the mite.
- Nodules may develop. These occur particularly at the elbows, anterior axillary folds, penis and scrotum. They are firm, dull red or brown, and may be very itchy. They may persist for weeks or months after treatment and do not necessarily indicate active infestation, but rather the result of a chronic allergic reaction to the mite. Inflammatory papules and nodules on the male genitalia, sometimes with visible burrows, are diagnostic of scabies.
- Thick skin is relatively resistant, so sparing is seen of the soles of the feet and upper back region in adults. Young children, the elderly and immunocompromised may also have palm and sole involvement, as well as lesions on the face, neck, ear and scalp.
- Even a single burrow is pathognomonic but burrows are often obliterated by bathing, scratching, crusts, or superinfection.
- Papules are small and erythematous. They can be sparse, or numerous and close-set. Over time papules can change into vesicles and bullae.
- Papules and vesicles frequently develop into excoriations, eczema exacerbations, secondary infections and crusts.
Crusted ('Norwegian') scabies
- Crusted scabies is a hyper-infestation with thousands of mites present in exfoliating scales, due to the host's insufficient immune response. Those at risk include:
- The immunosuppressed (eg, HIV infection, leukaemia or lymphoma).
- Elderly patients.
- Those with decreased peripheral sensation.
- Hyperkeratotic crusted lesions typically affect the hands, feet, nails, scalp and ears, but all areas of skin, including the scalp and trunk, may be involved.
- Crusted scabies is a hyperkeratotic skin disease resembling psoriasis.
- It may present with generalised lymphadenopathy and be associated with eosinophilia.
- Sepsis is a frequent complication as fissures provide an entry point for bacteria.
- This form of scabies is very contagious and is far more difficult to eradicate than classical scabies.
Misdiagnosis is common and other skin disorders, particularly those causing itching, should be considered, including:
- Insect bites
- Pubic lice and body lice
- Atopic eczema
- Contact dermatitis
- Lichen planus
- Dermatitis herpetiformis
- Systemic lupus erythematosus
- Bullous pemphigoid
- Urticaria pigmentosa
- Seborrhoeic dermatitis
- Prurigo nodularis
- The diagnosis is largely clinical. Dermatoscopy may help in identification of burrows or even occasionally mites.
- The ink burrow test can be helpful in confirming burrows. Ink is rubbed over a burrow (for example, with the surface of a fountain pen nib) then wiped off with an alcohol swab. Ink will track into a burrow, outlining it.
- The diagnosis can be confirmed by taking a skin scraping from an affected area, placing the material on a glass slide with a drop of 10% potassium hydroxide and seeing an adult mite, egg or eggshell under light microscopy.
- Whilst the sensitivity of skin scrapings is low, it is very specific and a mite or eggs seen under the microscope will remove any doubt.
- All members of the household, close contacts and sexual contacts should be treated simultaneously with the index patient. It is important that all contacts apply treatment on the same day to reduce the risk of re-infestation from an untreated contact. Patients should be advised to avoid close body contact until they and their partner(s) have completed treatment.
- The primary method of treatment for scabies is by topical application of a parasiticidal preparation overnight to the whole body from head to toe. This should be repeated a week later.
- Apply treatment to the whole body, including the scalp, neck, face, and ears, and especially between the fingers and toes and under the nails. Treatment should not be applied after a hot bath (as this increases systemic absorption and removes the drug from its treatment site). If the hands are washed, the liquid or cream must be reapplied.
- First-line: permethrin 5% dermal cream has been the most widely studied. It has been shown to be more effective than topical crotamiton and oral ivermectin. Patients with crusted 'Norwegian' scabies may require two or three applications on consecutive days to ensure that enough penetrates the hyperkeratotic areas to kill all the mites.
- Second-line: malathion 0.5% aqueous liquid.
- Crotamiton 10% cream or lotion: less effective than permethrin and is not recommended due to its poor efficacy. It may help to relieve the itch caused by scabies.
- Oral ivermectin (as a single oral dose of 200 micrograms/kg) is available on a named-patient basis as an adjunct to topical treatment for crusted ('Norwegian') scabies. This treatment is usually initiated on specialist advice.
- Seek specialist advice for children under 2 months old - scabies is rare in this age group.
- Breastfeeding or pregnant women with scabies can be treated with permethrin 5% dermal cream (or malathion if permethrin is contra-indicated), although neither is specifically licensed for such; there is, however, no indication that either product is harmful to the fetus or child. Breastfeeding mothers should remove the liquid or cream from the nipples before breastfeeding, and reapply treatment afterwards.
- Clothes, towels and bed linen should be machine-washed (at 50°C or above) to prevent re-infestation and transmission. Items that cannot be washed can be kept in plastic bags for at least 72 hours to contain the mites until they die.
- Outbreaks of scabies in a residential or nursing home should be referred to Public Health. All residents, staff and their families are treated simultaneously on an agreed treatment date.
- The risk of transmission of scabies is low in schools and children can return to school after the first application of treatment has been completed.
- Treatment of itch:
- Antihistamines are of little help in treating pruritus. A sedative oral antihistamine at night may help with sleeping and so reduce scratching.
- Crotamiton cream or lotion has soothing qualities and may help to relieve the itch caused by scabies.
- Low-dose steroid creams or simple emollients and moisturisers stored in the fridge may also ease discomfort.
- Suspect treatment failure where:
- Itching persists >6 weeks after the first application of an insecticide.
- Treatment was not applied as instructed or unco-ordinated between close contacts.
- New burrows appear.
- Secondary bacterial infections should be treated with antibiotics if significant.
- The British Association for Sexual Health and HIV (BASHH) guidelines, developed for use in GUM clinics, suggest that those with scabies should be offered full STI screening, as there is anecdotal evidence that rates of other infections are similar to other attendees.
- Scabies can cause flaring or reactivation of eczema or psoriasis.
- Secondary bacterial infection. This is a cause of much morbidity and mortality, especially in the developing world. Particularly involved are Staphylococcus aureus or Streptococcus pyogenes. Cellulitis, impetigo and abscesses may be the result, and bacterial skin infection can further predispose to invasive infection and sepsis. S. pyogenes infection secondary to scabies is a risk factor for acute post-streptococcal glomerulonephritis and possibly acute rheumatic fever. Crusted scabies has a high mortality rate due to secondary sepsis in the immunosuppressed.
- Scabies nodules may require intranodular corticosteroid injection for complete resolution.
- Those whose immunity is highly sensitive can present with extensive dermatitis or even erythroderma.
- Scabies has social stigma and may cause psychological harm with persistent delusions of parasitosis, shame or guilt.
- Scabies persists indefinitely unless treated. Treatment, if applied correctly, has a high chance of cure. In endemic areas, re-infestation is likely.Itching can persist for up to two weeks after treatment: warn patients that this does not mean treatment has failed. However, if itching is becoming more intense and persisting for more than six weeks, this is suggestive of treatment failure.
- Crusted scabies in those with HIV may be very difficult to eliminate and requires a longer treatment regimen.
Further reading and references
Scabies; DermNet NZ
Khalil S, Abbas O, Kibbi AG, et al; Scabies in the age of increasing drug resistance. PLoS Negl Trop Dis. 2017 Nov 3011(11):e0005920. doi: 10.1371/journal.pntd.0005920. eCollection 2017 Nov.
Scabies; Stanford University
Engelman D, Kiang K, Chosidow O, et al; Toward the global control of human scabies: introducing the International Alliance for the Control of Scabies. PLoS Negl Trop Dis. 2013 Aug 87(8):e2167. doi: 10.1371/journal.pntd.0002167. eCollection 2013.
Gunning K, Pippitt K, Kiraly B, et al; Pediculosis and scabies: treatment update. Am Fam Physician. 2012 Sep 1586(6):535-41.
FitzGerald D, Grainger RJ, Reid A; Interventions for preventing the spread of infestation in close contacts of people with scabies. Cochrane Database Syst Rev. 2014 Feb 242:CD009943. doi: 10.1002/14651858.CD009943.pub2.
Scabies; NICE CKS, November 2017 (UK access only)
Bernigaud C, Fischer K, Chosidow O; The Management of Scabies in the 21st Century: Past, Advances and Potentials. Acta Derm Venereol. 2020 Apr 20100(9):adv00112. doi: 10.2340/00015555-3468.
Hewitt KA, Nalabanda A, Cassell JA; Scabies outbreaks in residential care homes: factors associated with late recognition, burden and impact. A mixed methods study in England. Epidemiol Infect. 2014 Sep 8:1-10.
Engelman D, Yoshizumi J, Hay RJ, et al; The 2020 International Alliance for the Control of Scabies Consensus Criteria for the Diagnosis of Scabies. Br J Dermatol. 2020 Nov183(5):808-820. doi: 10.1111/bjd.18943. Epub 2020 Mar 29.
Anderson KL, Strowd LC; Epidemiology, Diagnosis, and Treatment of Scabies in a Dermatology Office. J Am Board Fam Med. 2017 Jan 230(1):78-84. doi: 10.3122/jabfm.2017.01.160190.
Management of scabies; British Association for Sexual Health and HIV (2016)
Hardy M, Engelman D, Steer A; Scabies: A clinical update. Aust Fam Physician. 201746(5):264-268.
British National Formulary (BNF); NICE Evidence Services (UK access only)
Gunning K, Kiraly B, Pippitt K; Lice and Scabies: Treatment Update. Am Fam Physician. 2019 May 1599(10):635-642.
Strong M, Johnstone PW; Interventions for treating scabies. Cochrane Database Syst Rev. 2007 Jul 18(3):CD000320.
Chandler DJ, Fuller LC; A Review of Scabies: An Infestation More than Skin Deep. Dermatology. 2019235(2):79-90. doi: 10.1159/000495290. Epub 2018 Dec 13.