Splenomegaly and Hypersplenism

Authored by , Reviewed by Dr Adrian Bonsall | Last edited | Meets Patient’s editorial guidelines

This article is for Medical Professionals

Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find one of our health articles more useful.

Treatment of almost all medical conditions has been affected by the COVID-19 pandemic. NICE has issued rapid update guidelines in relation to many of these. This guidance is changing frequently. Please visit https://www.nice.org.uk/covid-19 to see if there is temporary guidance issued by NICE in relation to the management of this condition, which may vary from the information given below.

The spleen is involved in producing protective humoral antibodies, the production and maturation of B and T cells and plasma cells, removal of unwanted particulate matter (eg, bacteria) and it also acts as a reservoir for blood cells, especially white cells and platelets. When the spleen is palpable it has usually reached at least twice its normal size.

  • Left upper quadrant (LUQ) mass or 'uncomfortable' abdominal pain; early satiety from compressed stomach.
  • Pancytopenia due to hypersplenism (see 'Hypersplenism' heading, below).

When considering whether an LUQ mass is an enlarged spleen, features of an enlarged spleen include that:

  • It moves with respiration.
  • It enlarges towards the right iliac fossa (RIF) - always start palpation in the RIF and move across towards the right upper quadrant (or a massive splenomegaly may be missed).
  • You cannot palpate above it - the upper margin lies under the ribs.
  • You may feel a notch.
  • It is dull to percussion.

Always remember to check for any accompanying lymphadenopathy and/or features of liver disease.

  • Liver biopsy.
  • Bone marrow biopsy.
  • Lymph node biopsy.
  • Haematological:
    • Haemolytic anaemias (eg, thalassaemia, red cell defects, sickle cell anaemia).
    • Acute leukaemias, chronic leukaemias.
    • Polycythaemia rubra vera.
    • Macroglobulinaemia.
    • Lymphoma (Hodgkin's disease and non-Hodgkin's lymphoma).
    • Essential thrombocythaemia.
    • Myelofibrosis.
  • Infections:
    • Malaria.
    • Schistosomiasis.
    • Visceral leishmaniasis (Kala-azar).
    • Tuberculosis, brucellosis.
    • Glandular fever, viral hepatitis.
    • Infective endocarditis.
  • Tumours and cysts:
    • Splenic abscesses.
    • Splenic metastases.
    • Cysts - eg, hydatid, dermoid.
    • Tumours - eg, haemangioma.
  • Congestive splenomegaly:
    • Liver cirrhosis.
    • Budd-Chiari syndrome.[1]
    • Portal or splenic vein obstruction.
    • Heart failure.
  • Connective tissue disorders:
    • Systemic lupus erythematosus.
    • Felty's syndrome.
  • Other disorders:
    • Gaucher's disease.
    • Niemann-Pick disease.
    • Histiocytosis X.
    • Amyloidosis.

Causes of massive splenomegaly

  • Chronic myeloid leukaemia.
  • Myelofibrosis, malaria (hyper-reactive malarial splenomegaly).
  • Leishmaniasis.
  • 'Tropical splenomegaly' (idiopathic; Africa, Southeast Asia).
  • Gaucher's disease.[1]

Splenomegaly in children

This is most commonly caused by infection, autoimmune disorders or haemolysis. It may be a presenting feature of neoplasia (eg, metastatic neuroblastoma). Causes include:

  • Infection: glandular fever, cytomegalovirus (CMV), other viral infections, often accompanied by lymphadenopathy; bacterial, protozoal, and fungal infections.
  • Autoimmune: juvenile rheumatoid arthritis.
  • Haemolysis: hereditary spherocytosis, sickle cell anaemia, thalassaemia.
  • Neoplasia: acute lymphoblastic leukaemia (ALL), Hodgkin's disease and non-Hodgkin's lymphoma (NHL), acute or chronic myeloblastic leukaemia, neuroblastoma.
  • Inherited diseases: Gaucher's disease and other storage disorders.
  • This is a pancytopenia occurring in patients with an enlarged spleen. It is due to large numbers of cells being pooled and destroyed in the spleen's reticulo-endothelial system, and haemodilution because of an increased plasma volume.
  • It can present with symptoms of anaemia, infection, or bleeding.
  • Bone marrow biopsy shows normal or hyperplastic marrow.
  • Splenic sequestration crisis may develop in young children with sickle cell anaemia, which can precipitate hypovolaemic shock and death, and is an indication for splenectomy.
  • Treatment of the cause.
  • Blood transfusions may be required.
  • Open or laparoscopic splenectomy may be indicated to control or stage the disease (eg, hereditary spherocytosis, Hodgkin's disease).
  • Patients with impaired splenic function need prophylactic vaccinations, etc (see separate article Splenectomy and Hyposplenism).

Further reading and references

  1. Pozo AL, Godfrey EM, Bowles KM; Splenomegaly: investigation, diagnosis and management. Blood Rev. 2009 May23(3):105-11. Epub 2008 Dec 4.

Hello. My spleen was removed in 2012 following injury and bleeding. I was always told to be aware of bacteriological infection and I take low dose antibiotics as prophylaxis. What is the function of...

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