Can I take Atorvastatin and Cardiace together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
There is no direct harmful interaction between atorvastatin and Cardicor (bisoprolol). In fact, these two medicines are very commonly prescribed together to protect the heart and blood vessels. However, both can occasionally cause tiredness or muscle aches, which may be more noticeable when taken together.
In this article:
Continue reading below
Why this happens
Atorvastatin works by lowering cholesterol in the liver, while Cardicor is a beta-blocker that slows the heart rate and reduces blood pressure. They work through entirely different pathways in the body and do not interfere with how the other is absorbed or cleared from the system.
What you should do
You can safely take these medicines together as prescribed by your doctor. It is usually best to take atorvastatin in the evening and Cardicor in the morning. If you develop unusual muscle pain, tenderness, or weakness, or feel excessively tired, mention this to your GP.
Continue reading below
Important precautions
Pregnancy
You must not take this medicine if you are pregnant or planning to become pregnant, as it may harm the unborn baby. Use effective contraception while taking it.
Muscle disorders
Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness. This can rarely lead to a serious condition called rhabdomyolysis which causes kidney damage.
Dietary (Grapefruit)
Avoid drinking large quantities of grapefruit juice (more than one or two small glasses a day), as it can significantly increase the level of the medicine in your blood and increase the risk of side effects.
Food and drink warnings
Grapefruit juice
Avoid drinking large quantities of grapefruit juice (more than 1.2 litres a day). Grapefruit contains compounds that can increase the level of atorvastatin in your blood, which may increase the risk of side effects like muscle pain or damage.
Alcohol
Avoid drinking large amounts of alcohol while taking this medicine. Both alcohol and atorvastatin can affect your liver; heavy drinking increases the risk of liver problems and may increase the risk of muscle side effects.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Magnesium and Bisoprolol together?
Taking magnesium and bisoprolol together can lead to an excessively slow heart rate or a significant drop in blood pressure. This may cause you to feel dizzy, lightheaded, or faint.

Treatment and medication
Can I take Bisoprolol and Trimbow pmdi // pressurised inhalation together?
Bisoprolol and Trimbow (which contains formoterol) work in opposite ways on the airways. Bisoprolol may cause the airways to narrow, making it harder to breathe and potentially triggering asthma or COPD symptoms. It also makes the formoterol in the Trimbow inhaler less effective at opening your airways.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.