Can I take Ciprofloxacin and Doxycycline together?

Why this happens

Both are antibiotics but they work in different ways. Doxycycline stops bacteria from growing (bacteriostatic), while ciprofloxacin actively kills them (bactericidal). In some cases, stopping the growth can make the 'killing' antibiotic less effective, though this is rarely a problem in clinical practice. Both drugs also share a side effect of making your skin more sensitive to UV light.

What you should do

You can take these together if your doctor has specifically prescribed both. Ensure you wear high-factor sunscreen and protective clothing, as both drugs increase your risk of severe sunburn. If you experience severe diarrhoea or stomach pain, contact your doctor immediately. Take them at least 2 hours apart from any antacids, dairy, or iron supplements, as these can stop both medicines from being absorbed properly.

Important precautions

Tendonitis or tendon rupture

Stop taking this medicine and seek immediate medical help if you experience pain, swelling, or inflammation in any tendon (such as the ankle or wrist).

Ciprofloxacin increases the risk of tendon rupture, even after the course is finished.

Sunlight exposure (Photosensitivity)

These medicine make your skin much more sensitive to sunlight. Avoid bright sunlight and do not use sunbeds; use a high-factor sun cream even on cloudy days to prevent severe skin reactions.

Dairy and Antacid interaction

Do not take these medicines at the same time as dairy products (like milk or yoghurt) or indigestion remedies (antacids). These can stop the medicine from being absorbed properly. Leave a gap of at least 2 hours between them.

Pregnancy and childhood

Doxycycline must not be taken during pregnancy or by children under 12 years old, as it can permanently discolour developing teeth and affect the growth of a baby's bones.

Food and drink warnings

Caffeine (coffee, tea, cola, energy drinks)

Ciprofloxacin can stop your body from breaking down caffeine as quickly as usual. This can lead to a build-up of caffeine in your system, making you feel shaky, restless, or causing a racing heartbeat and insomnia.

It is best to limit your caffeine intake while taking this medicine.

Alcohol

While there is no direct interaction between ciprofloxacin and alcohol, both can make you feel dizzy or lightheaded. It is generally advised to avoid alcohol until you know how the medicine affects you and until you have recovered from your infection.

Multivitamins and minerals (Iron, Magnesium, Zinc, Aluminium)

Supplements or fortified foods containing these minerals can stop these antibiotics from working. Take your medicine at least 2 hours before or 4-6 hours after any supplements or antacids.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.