Can I take Co-codamol and Hydroxycobalamin together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There are no known interactions between co-codamol and hydroxycobalamin. It is generally safe to take these two medications together.
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Why this happens
Co-codamol (a combination of paracetamol and codeine) and hydroxycobalamin (Vitamin B12) are processed by the body through different pathways. They do not interfere with each other's absorption, metabolism, or effectiveness.
What you should do
You can continue to take both medications as prescribed by your doctor. Always follow the dosage instructions on the packaging for co-codamol, as it contains codeine which can be addictive if used for more than three days without medical advice.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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