Can I take Creon 25000 and Morphine together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known interaction between Creon 25000 and morphine. They work in completely different ways in the body and do not interfere with each other's effectiveness or safety.
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Why this happens
Creon 25000 contains digestive enzymes (pancreatin) that work locally in the gut to help break down food. Morphine is an opioid painkiller that works on the central nervous system. These two medications do not share the same metabolic pathways or target the same receptors.
What you should do
You can safely take these two medications together as prescribed by your doctor. However, be aware that morphine can cause constipation, which is a common side effect. If you notice changes in your bowel habits while taking both, speak to your pharmacist or doctor for advice on managing constipation.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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