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Can I take Empagliflozin and Losartin together?

Drug interaction guide

Taking these two medicines together can increase the risk of low blood pressure (hypotension) and may affect your kidney function. You might feel dizzy, lightheaded, or faint, especially when standing up quickly. There is also a small risk of your blood potassium levels becoming too high.

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Why this happens

Both medicines work in different ways to lower blood pressure and affect how your kidneys handle fluids and salts. Losartan helps relax blood vessels and can cause the body to keep hold of potassium. Empagliflozin is a 'water tablet' (diuretic) type of medicine that makes you lose more fluid through your urine. Together, they can cause you to lose too much fluid (dehydration) or put extra strain on the kidneys.

What you should do

You can usually take these together, but your doctor should monitor your blood pressure and kidney function regularly through blood tests. Make sure you stay well-hydrated by drinking plenty of water. If you feel very dizzy, have a persistent headache, or feel unusually tired, contact your GP. Always stand up slowly from a sitting or lying position to avoid dizzy spells.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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