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Can I take Flecainide and Wegovy flextouch together?

Drug interaction guide

Wegovy (semaglutide) can slow down how quickly your stomach empties. This might change how your body absorbs flecainide, which is a medicine that needs to be kept at very specific levels in your blood to work safely and effectively. Additionally, both medications can occasionally affect your heart rhythm or heart rate.

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Why this happens

Wegovy is a GLP-1 receptor agonist that delays gastric emptying (the time it takes for food and pills to leave the stomach). This can delay or alter the absorption of oral medications like flecainide. Furthermore, semaglutide can sometimes increase resting heart rate, which may interact with the heart rhythm effects of flecainide.

What you should do

You should speak to your doctor before using these together. Because flecainide has a 'narrow therapeutic index' (meaning the difference between a safe dose and a dangerous dose is small), your doctor may want to monitor your blood levels or perform an ECG (heart trace) more frequently when you start or change your dose of Wegovy. Contact your doctor immediately if you feel dizzy, faint, or notice a change in your heartbeat.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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