Can I take Loratadine and Ibuprofen together?

Why this happens

Loratadine is an antihistamine used for allergies, and ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for pain and inflammation. They work in different ways in the body and are processed by different pathways in the liver and kidneys, meaning they do not interfere with each other's effectiveness or safety.

What you should do

You can take these medicines together if needed. Always follow the dosage instructions on the packaging for each product. If you have underlying health conditions, such as stomach ulcers, kidney problems, or asthma, check with a pharmacist before taking ibuprofen.

Important precautions

Asthma

Do not take ibuprofen if you have asthma, as it can cause a life-threatening worsening of your breathing or a severe allergic reaction.

Stomach ulcers or bleeding

Avoid ibuprofen if you have ever had a stomach ulcer, perforation, or bleeding, as it can cause serious damage to the stomach lining.

Pregnancy (third trimester)

Do not take ibuprofen if you are more than 6 months pregnant, as it can cause serious heart and kidney problems in the unborn baby and complications during birth.

Severe liver disease

Your body may process loratadine much more slowly, increasing the risk of side effects. You may need a lower dose or to take it less frequently.

Allergy skin testing

You must stop taking loratadine at least 48 hours before a skin prick test, as it can prevent a positive reaction and lead to inaccurate results.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking ibuprofen. Combining alcohol with non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen increases the risk of irritation to your stomach lining and can lead to stomach ulcers or bleeding.

It is best to avoid or strictly limit alcohol while taking loratadine. Although loratadine is a non-drowsy antihistamine, alcohol can increase the risk of side effects such as sleepiness, dizziness, or impaired concentration.

Food (General)

It is recommended to take ibuprofen with food or a glass of milk to reduce the risk of stomach upset or indigestion.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.