Alimemazine
Alfresed, Itzenal
Peer reviewed by Dr Colin Tidy, MRCGPLast updated by Michael Stewart, MRPharmSLast updated 30 Aug 2022
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Alimemazine is used to keep young children calm before an operation, and to ease allergic skin reactions.
The most common side effect is feeling sleepy or dizzy.
If you feel drowsy or sleepy, do not drive and do not use tools or machines.
At a glance
Alimemazine is an antihistamine used for allergic skin conditions and as a sedative for young children before operations.
It works by blocking histamine to ease itchiness and lumpiness from allergic reactions.
Common side effects include feeling sleepy or dizzy, dry mouth, and headache.
Do not drive or use machines if you feel drowsy or dizzy.
Avoid alcohol as it can increase drowsiness.
You cannot buy alimemazine over the counter in the UK.
Do not give alimemazine to children under 2 years old.
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Overview
Type of medicine | A phenothiazine antihistamine |
Used for | Some allergic skin conditions, and as a sedative for young children before an operation |
Also called | Trimeprazine (in US); Alfresed®, Itzenal® |
Available as | Tablets and oral liquid medicine |
What is alimemazine used for?
Back to contentsAlimemazine is a type of antihistamine used to relieve lumpy and itchy allergic skin reactions called hives (urticaria). It is also used before surgical procedures to help keep young children calm.
When alimemazine is prescribed for a young child who is about to have an operation, it produces a sedative effect which helps the child feel relaxed. Alimemazine is not suitable for children under 2 years of age.
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How does alimemazine work?
Back to contentsAlimemazine works by blocking a substance called histamine in the body. In some people, an excess of histamine is produced by exposure to substances such as pollen, pet fur, house dust or insect bites, and this causes allergic skin reactions.
By blocking histamine, alimemazine eases the itchiness and lumpiness of these reactions.
Side effects of alimemazine
Back to contentsCommon side effects of alimemazine include:
Feeling sleepy or dizzy.
Blurred vision.
Dry mouth.
Headache.
Upset stomach.
Feeling shaky or restless.
You will find a full list in the manufacturer's information leaflet supplied with your medicine.
The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
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How to manage alimemazine side effects
Back to contentsCommon alimemazine side effects | What can I do if I experience this? |
Feeling sleepy or dizzy, blurred vision | If this happens, do not drive and do not use tools or machines. You may feel light-headed, particularly when you first start taking this medicine. Getting up more slowly until you are aware how you react should help |
Dry mouth | Try chewing sugar-free gum or sucking sugar-free sweets |
Headache | Ask your doctor or pharmacist to recommend a suitable painkiller |
Stomach upset | Stick to simple meals |
Feeling shaky or restless, unusual or uncontrollable muscle movements | Speak with your doctor as soon as possible |
Sleeping problems, mood changes, stuffy nose, changes in sexual ability, breast changes or tenderness, menstrual problems, fast heartbeat, constipation, difficulty passing urine, rash | Discuss these with your doctor if any become troublesome |
If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.
Who should not take alimemazine?
Back to contentsBefore you start taking alimemazine it is important that your doctor or pharmacist knows:
If you are pregnant, trying for a baby or breastfeeding.
If you have a heart condition or blood vessel disease.
If you have liver, kidney, or prostate problems.
If you have any difficulties peeing or if you have been constipated for some time.
If you have breathing problems.
If you have any of the following: epilepsy, Parkinson's disease, depression, increased pressure in your eyes (glaucoma), or a condition called myasthenia gravis which causes muscle weakness.
If you have ever had yellowing of your skin or of the whites of your eyes (jaundice) or a blood disorder.
If you have low levels of thyroid hormone (hypothyroidism).
If you have a tumour on your adrenal gland (phaeochromocytoma).
If you have a rare inherited blood disorder called porphyria.
If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
If you have ever had an allergic reaction to another antihistamine, or to any other medicine.
How to take alimemazine
Back to contentsRead the leaflet before use. It contains important information about alimemazine and possible side effects.
Take alimemazine exactly as prescribed:
Adults and children aged 12 years and over: 10 mg, 2-3 times a day. A lower dose may be recommended if you are over 65.
Children aged 5-11 years: 5 mg, 3-4 times a day.
Children aged 2-4 years: 2.5 mg, 3-4 times a day.
Measure liquid medicine carefully. If giving alimemazine liquid to a child, use the measuring device provided and follow the dosing instructions on the bottle.
Take with or without food. Swallow tablets with a drink of water if preferred.
If you miss a dose, skip it. Take your next dose at the usual time. Do not take two doses together to make up for a missed dose.
Getting the most from your treatment
Back to contentsAlimemazine causes drowsiness. If you feel drowsy or sleepy, do not drive and do not use tools or machines.
Do not drink alcohol while you are on alimemazine as it increases the chance you will feel sleepy.
Alimemazine may cause your skin to become more sensitive than normal to sunlight. Use a sunscreen that protects against UVA light and has a sun protection factor (SPF) of at least 15, especially in strong sunlight or until you know how your skin reacts. Do not use sunbeds.
If you buy any medicines, check with a pharmacist that they are suitable to take with alimemazine. This is because a number of other medicines can interfere with the way alimemazine works or can increase the risk of side effects.
If you are having an operation or any dental treatment, tell the person carrying out the treatment that you are taking alimemazine.
How to store alimemazine
Back to contentsKeep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Frequently asked questions
Back to contentsHow quickly does alimemazine work?
Alimemazine usually starts to work within 15-30 minutes, although it may take longer for some people to feel the full effect. If you are taking it for itching or an allergic skin reaction, you should notice an improvement in your symptoms shortly after taking a dose.
How long does alimemazine stay in your system?
The effects of alimemazine can last for several hours. Some people may continue to feel drowsy the following day, especially after higher doses.
Can I take alimemazine every day?
Take alimemazine exactly as prescribed by your doctor. It may be used daily for some allergic conditions, but the length of treatment will depend on your symptoms and medical history.
Can I take alimemazine with other antihistamines?
Do not take alimemazine with other antihistamines unless your doctor or pharmacist advises you to. Combining antihistamines may increase the risk of side effects such as drowsiness and dizziness.
Can I drink alcohol while taking alimemazine?
It is best to avoid alcohol while taking alimemazine. Alcohol can increase drowsiness and make side effects such as dizziness more likely.
Can I buy alimemazine over the counter?
No. In the UK, alimemazine is generally available on prescription and is not usually sold over the counter.
Important information about all medicines
Back to contentsImportant information about all medicines
If you buy any medicines check with a pharmacist that they are safe to take with your other medicines.
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
If you are having an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.

Unsure about mixing medicines?
Check for possible interactions between medicines, supplements and foods before taking them together.
Further reading and references
- Manufacturer's PIL, Alimemazine Tartrate 10 mg Film-coated Tablets; Zentiva, The electronic Medicines Compendium. Dated January 2021.
- Manufacturer's PIL, Alimemazine Tartrate 7.5 mg/5 ml Syrup; Zentiva, The electronic Medicines Compendium. Dated September 2021.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewerView full bio

Dr Colin Tidy, MRCGP
General Practitioner, Medical Author
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 27 Feb 2027
30 Aug 2022 | Latest version

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