Clarithromycin for infection
Xetinin XL
Peer reviewed by Dr Colin Tidy, MRCGPLast updated by Michael Stewart, MRPharmSLast updated 29 May 2023
Meets Patient’s editorial guidelines
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Clarithromycin is a macrolide antibiotic. It can be taken by people who are allergic to penicillin.
It is important to complete the prescribed course (unless you are told to stop). Otherwise your infection could come back.
The most common side effects of clarithromycin are diarrhoea, feeling sick (nausea), tummy (abdominal) discomfort, and unusual tastes.
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About clarithromycin
Type of medicine | A macrolide antibiotic |
Used for | Bacterial infections including chest, skin, and ear infections Some types of stomach ulcers |
Also called | Xetinin XL® |
Available as | Tablets, ,modified-release tablets and oral liquid medicine |
What is clarithromycin used for?
Clarithromycin is a type of antibiotic used to treat bacterial infections such as respiratory infections, ear infections and skin infections.
Clarithromycin is also given to get rid of Helicobacter pylori. This is the bacterium believed to cause stomach ulcers. If you are prescribed it for this reason, you will also be prescribed other medicines to take alongside it.
It works by stopping the bacteria causing the infection from multiplying.
Clarithromycin can be taken by adults and children.
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Side effects of clarithromycin
Common side effects of clarithromycin are:
Feeling sick.
Being sick.
Stomach ache.
Farting (wind).
Indigestion.
Diarrhoea.
Changes to taste and smell.
Sore mouth.
Headache.
You will find a full list in the manufacturer's information leaflet supplied with your medicine.
The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
How to manage clarithromycin side effects
Common clarithromycin side effects (these affect fewer than 1 in 10 people) | What can I do if I experience this? |
Feeling sick or being sick, stomach ache, farting, indigestion | Stick to simple meals - avoid rich or spicy food |
Diarrhoea | Drink plenty of water to replace lost fluids. If the diarrhoea continues or is severe, speak with your doctor as soon as possible |
Tooth or tongue discolouration, and changes in the way things taste or smell | This will disappear after you finish your treatment |
Sore mouth | Speak with your doctor if this becomes a problem |
Headache | Ask your pharmacist to recommend a suitable painkiller |
If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.
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Who should not take clarithromycin?
Some medicines are not suitable for people with certain conditions. Before starting clarithromycin it is important that your doctor or pharmacist knows:
If you are pregnant or breastfeeding.
If you have any problems with the way your liver works or the way your kidneys work.
If you know you have an unusual heart rhythm.
If you have a muscle disorder called myasthenia gravis.
If you are taking any other medicines. In particular, if you are taking a 'statin' medicine for high cholesterol or colchicine for gout as well as herbal and complementary medicines.
If you have ever had an allergic reaction to a medicine.
How to take clarithromycin
Read the leaflet in the pack before starting clarithromycin. It explains how to take it and lists possible side effects.
Take exactly as your doctor tells you to and always check the label for the correct dose.
It is usually taken twice a day, in the morning and evening.
If you’re given a modified-release (XL) tablet, you only need to take one dose a day as it releases the medicine slowly throughout the day.
Standard tablets, liquid, and sachets can be taken before or after food. Modified-release (XL) tablets should be taken after food. Swallow whole, don’t chew or break them.
When clarithromycin is prescribed for a child, the dose will depend upon the child's weight. Make sure you read the label carefully so that you measure out the correct amount of medicine.
If you have been given clarithromycin sachets to take, open the sachet and mix the granules into a small glass of water before taking.
If you forget to take a dose, take one as soon as you remember. Do not take two doses at the same time to make up for a forgotten one.
Treatment usually lasts 5-14 days. Keep taking the antibiotic until you finish the course, even if you feel better, unless your doctor says otherwise. This helps stop the infection from coming back.
Getting the most from your treatment
Some people develop thrush (oral or vaginal) after taking a course of antibiotics. If this happens to you, speak with your doctor or pharmacist for advice about how to treat it.
This antibiotic may stop the oral typhoid vaccine from working. If you are having any vaccinations, make sure the person treating you knows that you are taking this medicine.
If you are taking a 'statin' medicine for high cholesterol your doctor may advise you to stop taking the statin whilst being treated with clarithromycin. Ask your doctor or pharmacist if you are unsure.
Clarithromycin usually doesn’t affect the contraceptive pill, but diarrhoea, vomiting, or breakthrough bleeding may reduce its effectiveness. Ask your doctor or pharmacist for advice if this happens.
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking clarithromycin.
If you buy any medicines, check with a pharmacist that they are suitable to take with this antibiotic.
If you still feel unwell after completing your course of the antibiotic, make another appointment to see your doctor.
How to store clarithromycin
Keep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
If you have been given liquid medicine, it will have been made up by the pharmacy and it lasts for a limited number of days only. Check the expiry date on the bottle and do not use it after this date.
Important information about all medicines
Important information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
If you are having an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.
Frequently asked questions
How long does it take for clarithromycin to work?
Clarithromycin usually starts to improve symptoms within 2-3 days. Full recovery can take 7-14 days, depending on the type and severity of the infection.
Is clarithromycin safe to take during pregnancy?
Clarithromycin is generally not recommended during pregnancy, especially in the first trimester. Your doctor may prescribe a safer alternative antibiotic if needed.
Can you drink alcohol with clarithromycin?
It’s best to avoid alcohol while taking clarithromycin, as it can increase the risk of side effects like nausea, stomach upset, or dizziness. Limiting alcohol helps the medication work more effectively and keeps you comfortable.
What should you avoid when taking clarithromycin?
You should avoid alcohol and certain medications that can interact with clarithromycin, including some statins and heart medicines. Always check with your doctor or pharmacist before taking new medicines or supplements.
Further reading and references
- Manufacturer's PIL, Clarithromycin 250 mg & 500 mg Tablets; Aurobindo Pharma - Milpharm Ltd, The electronic Medicines Compendium. Dated July 2021.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 28 May 2026
29 May 2023 | Latest version

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