Dexibuprofen tablets for pain and inflammation
Peer reviewed by Dr Colin Tidy, MRCGPLast updated by Michael Stewart, MRPharmSLast updated 18 Mar 2023
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Dexibuprofen is a medicine called a non-steroidal anti-inflammatory drug. It is also known as 'an NSAID'.
Before you take dexibuprofen, tell your doctor if you have ever had an allergic reaction to any other anti-inflammatory painkiller.
The most common side effects of dexibuprofen are indigestion, stomach pain, and feeling sick (nausea).
It is usual to take either two or three tablets a day - your doctor will tell you which of these is right for you. Take the tablets with food.
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About dexibuprofen
Type of medicine | A non-steroidal anti-inflammatory drug (NSAID) |
Used for | Relief of pain and inflammation |
Available as | Tablets |
What is dexibuprofen used for?
Dexibuprofen is a type of anti-inflammatory painkiller called non-steroidal anti-inflammatory drugs (NSAIDs), or sometimes just 'anti-inflammatories'.
It is used to treat painful conditions such as arthritis, sprains and strains, period (menstrual) pain, and dental pain.
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How does dexibuprofen work?
Dexibuprofen works by blocking COX enzymes in the body. These enzymes help produce prostaglandins, chemicals that cause pain and inflammation at injured areas.
When dexibuprofen blocks COX enzymes, fewer prostaglandins are made, so pain and inflammation decrease.
Side effects of dexibuprofen
Common side effects of dexibuprofen are:
Indigestion.
Heartburn (reflux).
Stomach pain.
Diarrhoea.
Feeling sick.
Being sick (vomiting).
A full list of the side effects can be found in the manufacturer's printed information leaflet supplied with the medicine. Speak with your doctor or pharmacist if any side effects continue or become troublesome.
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How to manage dexibuprofen side effects
Common dexibuprofen side effects | What can I do if I experience this? |
Indigestion, heartburn, stomach pain | Remember to take your doses with a meal or with a glass of milk. If the discomfort continues, speak with your doctor |
Diarrhoea | Drink plenty of water to replace the lost fluids |
Feeling sick or being sick | Stick to simple meals - avoid fatty or spicy foods |
Feeling dizzy or tired | Do not drive and do not use tools or machines while affected |
Skin rash | If you develop a severe, itchy skin rash stop taking dexibuprofen and let your doctor know straightaway |
Important: if you experience any of the following less common but possibly serious symptoms, stop taking dexibuprofen and contact your doctor for advice straightaway:
If you have any breathing difficulties such as wheeze or breathlessness.
If you have any signs of an allergic reaction such as swelling around your mouth or face, or a severe itchy skin rash.
If you pass blood or black stools, bring up blood, or have severe tummy (abdominal) pains.
If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.
Who should not take dexibuprofen?
Some medicines aren’t suitable for everyone. Before taking dexibuprofen, your doctor needs to know:
If you have ever had an allergic reaction to any other NSAID (such as aspirin, naproxen, diclofenac, and indometacin), or to any other medicine.
If you have ever had a problem with bleeding from the stomach or intestines, such as from a peptic or duodenal ulcer.
If you have asthma or any other allergic disorder.
If you have a heart condition, or a problem with your blood vessels or circulation.
If you are pregnant, trying for a baby, or breastfeeding.
If you have ever had blood clotting problems.
If you have an inflammatory bowel disorder such as Crohn's disease or ulcerative colitis.
If you have high blood pressure.
If you have a connective tissue disorder such as systemic lupus erythematosus. This is an inflammatory condition which is also called lupus or SLE.
If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work.
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
How to take dexibuprofen
Read the leaflet that comes with the medicine before you start. It explains how dexibuprofen works and lists possible side effects.
Take one 300 mg tablet two or three times a day, exactly as your doctor tells you.
Take the tablet with food, ideally at mealtimes. This helps protect your stomach. Swallow it with a glass of water.
If you miss a dose, take it when you remember unless it’s almost time for the next one. If it is, skip the missed dose. Do not take two doses at the same time.
Getting the most from your treatment
Your doctor will prescribe the lowest dose for the shortest time to reduce side effects.
For long-term use you may be given another medicine to protect your stomach.
Keep your doctor appointments, especially if you are taking dexibuprofen long-term, so your progress can be checked.
If you have asthma, dexibuprofen may make breathing problems worse. If you notice wheezing or shortness of breath, stop taking it and see your doctor straight away.
Long-term use can slightly increase the risk of heart and blood vessel problems. Your doctor will explain this and choose the safest dose. Do not take more than prescribed.
Check with a pharmacist before taking other medicines. Do not take dexibuprofen with other anti-inflammatory painkillers, including some cold and flu medicines.
If you are due to have an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
How to store dexibuprofen
Keep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Important information about all medicines
Important information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.
Frequently asked questions
How long does it take for dexibuprofen to work?
Dexibuprofen usually starts to work within 30-60 minutes of taking it, with peak pain relief often happening after 1-2 hours. Taking dexibuprofen with food may slightly slow how fast it works, but it helps protect your stomach.
Can you drink alcohol with dexibuprofen?
Drinking a small amount of alcohol with dexibuprofen is generally considered safe, however drinking alcohol can increase the risk of stomach irritation, indigestion, or bleeding. It is best to avoid or limit alcohol until your treatment is finished.
Is it safe to take dexibuprofen during pregnancy?
Dexibuprofen is not recommended during pregnancy, especially in the third trimester, as it may harm the unborn baby or cause complications. Let your doctor know if you are pregnant, think you may be pregnant, or are planning a pregnancy.
Further reading and references
- Manufacturer's PIL, Dexibuprofen 300 mg Film-coated Tablets; Strides Pharma UK Ltd, The electronic Medicines Compendium. Dated January 2021.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 17 Mar 2026
18 Mar 2023 | Latest version
23 Mar 2011 | Originally published
Authored by:
Helen Allen, MPharm

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