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Dexketoprofen for pain

Keral

Dexketoprofen is a painkiller. It is called a non-steroidal anti-inflammatory drug. It is also known as an 'NSAID'.

The usual dose is either half a 25 mg tablet every 4-6 hours, or one 25 mg tablet every eight hours. Your doctor will tell you which dose is right for you.

Pain relief is more rapid if dexketoprofen is taken when your stomach is empty - this means taking the tablets about 30 minutes before food.

The most common side effects of dexketoprofen are feeling sick (nausea), indigestion, and stomach pain.

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About dexketoprofen

Type of medicine

A non-steroidal anti-inflammatory drug (NSAID)

Used for

Short-term painful conditions

Also called

Keral®; Skudexa® (dexketoprofen with tramadol)

Available as

Tablets

What is dexketoprofen used for?

Dexketoprofen is a type of anti-inflammatory painkiller called non-steroidal anti-inflammatory drugs (NSAIDs).

It is used to treat short-term painful conditions such as muscular sprains and strains, period (menstrual) pain, and toothache.

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How does dexketoprofen work?

Dexketoprofen works by blocking COX enzymes in the body. These enzymes help produce prostaglandins, chemicals that cause pain and inflammation.

When dexketoprofen blocks COX enzymes, fewer prostaglandins are made, so pain and inflammation decrease.

Side effects of dexketoprofen

Common side effects of dexketoprofen include:

  • Indigestion.

  • Heartburn.

  • Stomach pain.

  • Feeling sick.

  • Being sick (vomiting).

  • Diarrhoea.

A full list of the side effects can be found in the manufacturer's printed information leaflet supplied with the medicine. Speak with your doctor or pharmacist if any side effects continue or become troublesome.

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How to manage dexketoprofen side effects

Common dexketoprofen side effects (these affect fewer than 1 in 10 people)

What can I do if I experience this?

Indigestion, heartburn, stomach pain

If troublesome, speak with your doctor

Feeling sick or being sick, diarrhoea

Drink plenty of liquid to replace any lost fluids. Try taking the tablets after meals

Important: if you experience any of the following rare but possibly serious symptoms, stop taking dexketoprofen and contact your doctor for advice straightaway:

  • If you have any breathing difficulties such as wheeze or breathlessness.

  • If you have any signs of an allergic reaction such as swelling around your mouth or face, or an itchy skin rash.

  • If you pass blood or black stools, bring up (vomit) blood, or have severe stomach pains.

If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist for further advice.

Who should not take dexketoprofen?

Some medicines aren’t suitable for everyone. Before taking dexketoprofen, your doctor needs to know:

  • If you have ever had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn's disease or ulcerative colitis.

  • If you have asthma or any other allergic disorder.

  • If you are pregnant, trying for a baby, or breastfeeding.

  • If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work.

  • If you have a heart condition or a problem with your blood vessels or circulation.

  • If you have high blood pressure.

  • If you have any blood clotting problems.

  • If you have high blood sugar or cholesterol levels.

  • If you have a connective tissue disorder such as systemic lupus erythematosus. This is an inflammatory condition which is also called lupus or SLE.

  • If you are taking any other medicines which are available to buy without a prescription, as well as herbal and complementary medicines.

  • If you have ever had an allergic reaction to any other NSAID (such as aspirin, ibuprofen, diclofenac, and indometacin), or to any other medicine.

How to take dexketoprofen

  • Read the leaflet that comes with the medicine before you start. It explains how dexketoprofen works and lists possible side effects.

  • Depending on your condition, you may take half a tablet every 4-6 hours or one tablet every 8 hours. Stop taking the tablets once the pain has gone.

  • Do not take more than three 25 mg tablets per day.

  • Take the tablets with water. They work faster on an empty stomach (about 30 minutes before food), but if they make you feel sick, take them after eating.

  • If you forget a dose, take it as soon as you remember unless it’s almost time for your next dose. Do not take two doses at once.

Getting the most from your treatment

  • Your doctor will prescribe the lowest dose for the shortest time to reduce side effects.

  • Keep any follow-up appointments with your doctor. This is so your doctor can check on your progress.

  • If you have asthma, symptoms such as wheeze or breathlessness can be made worse by dexketoprofen. If this happens to you, you should stop taking the tablets and see your doctor as soon as possible.

  • Check with a pharmacist before taking any other medicines. Do not take dexketoprofen with other anti-inflammatory painkillers, including some over-the-counter cold and flu remedies.

  • If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.

How to store dexketoprofen

  • Keep all medicines out of the reach and sight of children.

  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines

Important information about all medicines

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Report side effects to a medicine or vaccine

If you experience side effects, you can report them online through the Yellow Card website.

Frequently asked questions

How long does it take for dexketoprofen to work?

Dexketoprofen usually starts to work within 30 minutes after taking it, with full pain relief often felt after about 1 hour.

Can you drink alcohol with dexketoprofen?

It’s best to avoid alcohol while taking dexketoprofen. Drinking alcohol can increase the risk of stomach irritation, indigestion, or bleeding, especially if the medicine is taken regularly or on an empty stomach.

Is it safe to take dexketoprofen during pregnancy?

Dexketoprofen is not recommended during pregnancy, particularly in the third trimester, as it may cause complications for the baby. Let your doctor know if you are pregnant or are planning on becoming pregnant.

Is dexketoprofen stronger than ibuprofen?

Dexketoprofen is a more active form of ibuprofen, so smaller doses may work faster and may be more effective for some types of pain.

Further reading and references

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

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