Duloxetine for mood and nerve disorders

About duloxetine

What is duloxetine used for?

Duloxetine is a type of antidepressant called a serotonin and noradrenaline reuptake inhibitor (SNRI). It is used to treat depression, anxiety disorders, and pain caused by nerve damage in people with diabetes, called diabetic neuropathy.

Duloxetine is thought to work by regulating the levels of certain chemicals in your brain, called serotonin and noradrenaline/norepinephrine, helping to improve symptoms of depression, anxiety, and nerve pain.

Other uses

Duloxetine is also prescribed for treating urinary symptoms, although a different brand and strength of capsule are used. There is a separate medicine leaflet called Duloxetine for urinary symptoms, giving more information about duloxetine when used for this condition.

Side effects of duloxetine

The most common side effects of duloxetine are:

• Feeling sick.

• Dry mouth.

• Constipation.

• Diarrhoea.

• Feeling dizzy, tired or sleepy.

• Headache.

• Sweating.

• Feeling anxious or shaky.

• Trouble sleeping.

• Reduced sex drive (libido).

You will find a full list in the manufacturer's information leaflet supplied with your medicine.

The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

How to manage duloxetine side effects

If you experience any other symptoms which you think may be due to the medicine, please speak with your doctor or pharmacist for further advice

Who should not take duloxetine?

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking duloxetine it is important that your doctor knows:

• If you are pregnant, trying for a baby or breastfeeding.

• If you have problems with the way your liver works, or with the way your kidneys work.

• If you have a heart condition.

• If you have increased eye pressure (called glaucoma).

• If you have high blood pressure.

• If you have ever had 'high' moods, such as mania in bipolar disorder.

• If you have ever had a fit (seizure).

• If you have a blood disorder that increases your risk of bleeding.

• If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

• If you have ever had an allergic reaction to a medicine.

How to take duloxetine

• Read the manufacturer's printed information leaflet from inside the pack. It will give you more information about duloxetine and will provide you with a full list of the side effects which you may experience from taking it.

• Take duloxetine exactly as your doctor tells you to. The usual dose is one capsule of either 30 mg or 60 mg daily.

  • When starting duloxetine, your doctor may give you the lower strength of capsules to begin with, and then increase the strength as you go on.

• Try to take your doses at the same time of day each day, as this will help you to remember to take your doses regularly.

  • You can take duloxetine either before or after meals. Swallow the capsule whole with a drink of water to help you to swallow it.

• If you forget to take a dose at your usual time, take it when you remember. If you do not remember until the following day then leave out the forgotten dose and take your next dose when it is due. Do not take two doses together to make up for a missed dose.

Getting the most from your treatment

• Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress and review your treatment.

• You may feel that duloxetine is not helping you straightaway. If you are taking duloxetine for depression or anxiety, it can take a week or two before the effect builds up and 2-4 weeks before you feel the full benefit.

• If you are taking duloxetine for nerve pain damage, it can take several weeks before you feel better. Do not stop taking the capsules after a week or so, even if you think they are not working.

• If you are taking duloxetine for depression, you should expect that a normal course of treatment will last for around six months after your symptoms have eased.

  • There are several types of antidepressants and they differ in their possible side effects - if you find that duloxetine does not suit you then let your doctor know, as another may be found that will.

• If you drink alcohol, ask your doctor for advice about drinking while you are on duloxetine. Drinking alcohol can increase the risk of unwanted effects from duloxetine, such as dizziness and blurred vision.

• If you buy any medicines, check with a pharmacist that they are suitable to take with duloxetine. This is because some herbal medicines (such as St John's wort) can increase the risk that you will experience unwanted effects.

• If you are having an operation or dental treatment, please tell the person carrying out the treatment that you are taking duloxetine.

• Keep taking duloxetine until your doctor tells you otherwise. Your treatment is likely to last for a number of months.

  • Stopping suddenly can cause symptoms such as headache, sickness, anxiety, dizziness, shakiness and sleeping problems. Your doctor will reduce your dose gradually over a week or two to reduce the risk of these sorts of problems.

How to store duloxetine

• Keep all medicines out of the reach and sight of children.

• Store in a cool, dry place, away from direct heat and light.

Important information about all medicines

Frequently asked questions

Does duloxetine cause weight gain?

Duloxetine is not strongly linked with weight gain, however some people may notice changes in their weight. It's important to speak to your doctor if you're concerned.

What is the most common side effect of duloxetine?

The most common side effect of duloxetine is feeling sick (nausea), although other issues like dry mouth or sleep changes can also occur. These side effects often go away over time.

How long can you take duloxetine for nerve pain?

How long you can take duloxetine for nerve pain depends on your individual needs and how well the medicine works for you. Some people may only need it for a few months, while others stay on it longer to keep their symptoms under control.

Is duloxetine addictive?

Duloxetine is not considered addictive. However, stopping it suddenly can cause withdrawal symptoms such as dizziness, headaches, or irritability. For this reason, your doctor will usually advise reducing the dose gradually if you decide to stop.