Hydrocortisone muco-adhesive tablets for mouth ulcers
Peer reviewed by Sid DajaniLast updated by Michael Stewart, MRPharmSLast updated 26 Mar 2023
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Use one tablet four times a day. Put the tablet as close to the ulcer as you can. It will gently stick to the lining of your mouth and dissolve slowly.
If your symptoms do not improve within five days, make an appointment to see your doctor or dentist for further advice.
At a glance
Hydrocortisone muco-adhesive tablets are a corticosteroid medicine for painful mouth ulcers.
They help to speed up healing and reduce the pain.
Place a tablet next to the ulcer; it will stick and dissolve slowly.
Use one tablet four times a day, unless advised otherwise.
Consult a doctor or dentist if symptoms do not improve within five days.
Do not use if you are pregnant, breastfeeding, or have a mouth infection, before speaking to a doctor.
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About hydrocortisone muco-adhesive tablets
Type of medicine | A corticosteroid medicine |
Used for | Relief of painful mouth ulcers |
Available as | Tablets which stick to the lining of your mouth (muco-adhesive buccal tablets) |
Mouth ulcers are painful sores which occur within the mouth. Although many mouth ulcers heal on their own without treatment, hydrocortisone muco-adhesive tablets can help mouth ulcers heal more quickly. They also help to ease the pain. Muco-adhesive buccal tablets are designed to be placed next to the ulcer, and to dissolve slowly in your mouth.
Hydrocortisone muco-adhesive tablets are available on prescription from doctors and dentists, or you can buy them without a prescription at pharmacies. However, if you have any other symptoms in addition to the mouth ulcers, it is important that you speak with a doctor before using the tablets.
Before using hydrocortisone muco-adhesive tablets
Back to contentsTo make sure that this is the right treatment for you, before you start using hydrocortisone muco-adhesive tablets it is important that your doctor, dentist or pharmacist knows:
If you are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
If you think you may have a mouth infection.
If the treatment is intended for a child under 12 years of age. The tablets should only be given to children aged under 12 years on the advice of a doctor.
If you have ever had an allergic reaction to a medicine.
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
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How to use hydrocortisone muco-adhesive tablets
Back to contentsBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about the tablets, and it will also provide you with a full list of the side-effects which you could experience.
Place one tablet as close to the mouth ulcer as you can. It will stick gently to the lining of your mouth, and then dissolve slowly to allow the medicine it contains to come into contact with the ulcer. Do not suck the tablet, and try not to move it around your mouth.
Unless you have been told otherwise, use one tablet four times a day until the ulcer has healed. Space the doses out evenly throughout the day.
If your symptoms do not improve within five days, make an appointment to see a doctor or dentist for further advice. Also, if your symptoms improve but then come back again, you should make an appointment to see a doctor for further advice and a check-up.
Getting the most from your treatment
Back to contentsDo not use more than the recommended dose of one tablet four times daily. If you forget a dose, don't worry. Do not use two tablets at the same time to make up for a missed dose.
It may help to avoid spicy foods, acidic fruit drinks, and very salty foods (such as crisps). These can all make the pain and stinging of ulcers worse.
Some people find it helps to use a straw to drink with. This helps to avoid liquids from touching ulcers at the front of your mouth. Do not however use a straw to drink hot drinks, as this can cause you to burn your throat.
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Can hydrocortisone muco-adhesive tablets cause problems?
Back to contentsAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the ones associated with hydrocortisone muco-adhesive tablets, although these are uncommon. The best place to find a full list of the side-effects is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below.
Hydrocortisone muco-adhesive tablet side-effects | What can I do if I experience this? |
Oral thrush (the symptoms of thrush are a sore red mouth, with white 'furry' patches on the tongue or the insides of the cheeks) | Speak with your doctor, dentist or pharmacist for treatment advice |
Worsening of diabetes; worsening of mouth infections | Check with a doctor for advice |
Allergic-type reactions | Stop using the tablets and speak with a doctor for further advice |
If you experience these or any other symptoms which you think may be due to the tablets, speak with a doctor or pharmacist for further advice.
How to store hydrocortisone muco-adhesive tablets
Back to contentsKeep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Important information about all medicines
Back to contentsImportant information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
If you are having an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.

Unsure about mixing medicines?
Check for possible interactions between medicines, supplements and foods before taking them together.
Frequently asked questions
Can I use hydrocortisone muco-adhesive tablets for any type of mouth sore?
Hydrocortisone muco-adhesive tablets are specifically used for the relief of painful mouth ulcers. If you are experiencing other symptoms in addition to the mouth ulcers, you should speak with a doctor before using them. Also, if you suspect you might have a mouth infection, these tablets may not be suitable.
How do these tablets work to heal mouth ulcers?
These tablets are designed to stick gently to the lining of your mouth near the ulcer and dissolve slowly. This allows the hydrocortisone medicine they contain to come into direct contact with the ulcer, helping it heal more quickly and easing pain.
What should I do if my mouth ulcer doesn't get better after using the tablets?
If your symptoms do not improve within five days of using the tablets, you should make an appointment to see a doctor or dentist for further advice. Similarly, if your symptoms improve but then return, you should also seek advice from a doctor.
Can I eat or drink normally while using these tablets?
While using the tablets, it is recommended to avoid spicy foods, acidic fruit drinks, and very salty foods like crisps, as these can make the pain and stinging of ulcers worse. Some people find using a straw to drink liquids helpful to avoid contact with ulcers, but do not use a straw for hot drinks as this could cause burns.
What if I accidentally swallow the tablet instead of letting it dissolve?
The instructions state not to suck the tablet and to try not to move it around your mouth, as it's designed to stick and dissolve slowly to deliver medication to the ulcer site. The article does not specify what happens if swallowed, but rather focuses on proper application for effectiveness.
Is it possible to get oral thrush from using these tablets?
Yes, oral thrush is an uncommon side-effect associated with hydrocortisone muco-adhesive tablets. Symptoms of oral thrush include a sore red mouth with white 'furry' patches on the tongue or insides of the cheeks. If you experience these symptoms, you should speak with your doctor, dentist, or pharmacist for advice.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 25 Sept 2027
26 Mar 2023 | Latest version

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