Hydroxyzine tablets
Peer reviewed by Dr Colin Tidy, MRCGPLast updated by Michael Stewart, MRPharmSLast updated 27 Apr 2023
Meets Patient’s editorial guidelines
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Hydroxyzine is an antihistamine. It is taken to relieve itching.
The most common side effect is drowsiness. This may affect your ability to drive.
At a glance
Hydroxyzine is an antihistamine medicine used to relieve itching caused by skin conditions like nettle rash.
It works by blocking histamine, a chemical that can cause skin rash and itchiness.
Common side effects include feeling dizzy or sleepy, blurred vision, headache, and dry mouth.
Do not drive or use tools/machines if you feel dizzy or sleepy, and avoid alcohol.
Always follow your doctor's instructions on how to take hydroxyzine.
Do not take hydroxyzine if you are pregnant, over 65, or have certain health conditions without discussing with your doctor.
Hydroxyzine is a prescription-only medicine and cannot be bought over the counter.
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Overview
Type of medicine | An antihistamine |
Used for | Itching, urticaria |
Available as | Tablets |
What is hydroxyzine used for?
Back to contentsHydroxyzine belongs to a group of medicines known as sedating antihistamines. It is used to relieve itching caused by some skin conditions, such as nettle rash (urticaria).
How does hydroxyzine work?
Exposure to substances such as pollen, pet fur, house dust or insect bites can cause some people to produce an excess of a chemical called histamine.
This release of histamine can then cause a skin rash and/or itchiness. Because hydroxyzine blocks the effects of histamine, it helps relieve symptoms like these.
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Side effects of hydroxyzine
Back to contentsCommon side effects of hydroxyzine include:
Feeling dizzy or sleepy.
Blurred vision.
Headache.
Dry mouth.
Difficulty peeing.
Upset stomach.
You will find a full list in the manufacturer's information leaflet supplied with your medicine.
How to manage hydroxyzine side effects
Back to contentsThe unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any continue or become troublesome.
Hydroxyzine side effects | What can I do if I experience this? |
Feeling dizzy or sleepy, and blurred vision | Do not drive and do not use tools or machines. Do not drink alcohol |
Headache | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know |
Dry mouth | Try sucking sugar-free sweets or chewing sugar-free gum |
Difficulty passing urine | Speak with your doctor if this becomes troublesome |
Stomach upset | Stick to simple meals - avoid rich or spicy foods |
If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist for further advice.
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Who should not take hydroxyzine
Back to contentsTo make sure that this is the right treatment for you, before you start taking hydroxyzine it is important that you discuss the treatment with a doctor or pharmacist if:
You are pregnant, trying for a baby or breastfeeding.
You are over 65 years of age. This is because you could be more susceptible to side effects.
You have a problem with the way your liver works, or if you have a problem with your kidneys.
You have a condition which causes increased pressure in your eyes, such as glaucoma.
You have prostate problems, or if you have been experiencing any difficulty passing urine.
You know you have an unusual heart rhythm.
You know you have a blockage in your small intestines.
You have epilepsy.
You have any long-term breathing problems, such as asthma or bronchitis.
You have a rare inherited blood condition known as porphyria.
You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
You have ever had an allergic reaction to a medicine.
How to take hydroxyzine
Back to contentsRead the information leaflet in the pack before you start taking hydroxyzine. It explains how the medicine works and lists possible side effects.
Take hydroxyzine as your doctor tells you. Usually, take 1 dose at night, sometimes you may need extra doses during the day.
You can take it with or without food. Take it with water if that helps.
If you miss a dose, skip it and take the next one at the normal time. Do not take 2 doses together.
You usually only need it for a short time. Stop taking it when your symptoms get better.
Getting the most from your treatment
Back to contentsHydroxyzine may make you feel sleepy. If it does, do not drive or use tools or machines.
Do not drink alcohol, as it can make the sleepiness worse.
Tell your doctor, nurse, or dentist you are taking hydroxyzine before any operation, treatment, or tests, especially allergy tests. You may need to stop it for a short time.
Your skin may become more sensitive to sunlight. Use sunscreen (SPF 15 or higher with UVA protection) and avoid sunbeds.
Check with a pharmacist before taking other medicines, as some can interact with hydroxyzine and increase side effects.
How to store hydroxyzine
Back to contentsKeep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Important information about all medicines
Back to contentsImportant information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.
Frequently asked questions
Back to contentsCan I buy hydroxyzine over the counter?
No, hydroxyzine is not available over the counter in the UK or the US. It is a prescription-only medication that must be prescribed by a doctor or other licensed healthcare professional.
How long does it take for hydroxyzine to work?
Hydroxyzine usually starts working within 15 to 30 minutes after taking it. Most people notice its calming or sedating effects within the first hour.
How long does hydroxyzine last?
Hydroxyzine typically lasts around 4 to 6 hours, with the strongest calming or sedating effects usually felt during that time. Although the noticeable effects wear off after a few hours, the medication can remain in your body for several days.
Can I drink alcohol on hydroxyzine?
No, it is best to avoid drinking alcohol while taking hydroxyzine. Combining the two can increase drowsiness, dizziness, and the risk of impaired coordination and slowed breathing.
Can I take hydroxyzine while pregnant?
Hydroxyzine should only be taken during pregnancy if prescribed by a doctor, as it may not be suitable for everyone. Your healthcare provider can advise whether the benefits outweigh any potential risks and discuss safer alternatives if needed.

Unsure about mixing medicines?
Check for possible interactions between medicines, supplements and foods before taking them together.
Frequently asked questions
Can children take hydroxyzine for itching?
The article does not specify age restrictions for children taking hydroxyzine. You would need to check with a doctor or pharmacist as the dosage and suitability can vary depending on a child's age and specific condition.
Will hydroxyzine interact with my other medications?
Yes, hydroxyzine can interact with other medicines. It's important to tell your doctor or pharmacist about all other medicines you are taking, including those bought without a prescription, as well as herbal and complementary medicines. This is because some combinations can increase side effects.
What should I do if I forget to take a dose of hydroxyzine?
If you miss a dose of hydroxyzine, you should skip that missed dose and take the next one at the normal time. Do not take two doses together to make up for the forgotten one.
How long should I continue taking hydroxyzine?
You usually only need to take hydroxyzine for a short time. You should stop taking it once your symptoms improve.
Can hydroxyzine make my skin more sensitive to the sun?
Yes, hydroxyzine can make your skin more sensitive to sunlight. It's recommended to use sunscreen with an SPF of 15 or higher and UVA protection, and to avoid sunbeds while taking this medicine.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewerView full bio

Dr Colin Tidy, MRCGP
General Practitioner, Medical Author
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 25 Oct 2027
27 Apr 2023 | Latest version

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