Phenoxymethylpenicillin for infection
Penicillin V
Peer reviewed by Sid DajaniLast updated by Michael Stewart, MRPharmSLast updated 19 Dec 2022
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Phenoxymethylpenicillin is a type of penicillin - do not take it if you are allergic to penicillin. Make sure you tell your doctor if you are allergic to penicillin.
Space your doses out evenly over the day and complete the full course of the antibiotic, even if you feel your infection has cleared up.
Take phenoxymethylpenicillin when your stomach is empty of food (so an hour before you eat, or two hours afterwards).
Common side effects include nausea, vomiting, diarrhoea, and thrush.
If you have an allergic reaction (such as any swelling around your mouth, any difficulties breathing or a red rash) contact a doctor straightaway.
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About phenoxymethylpenicillin
Type of medicine | A penicillin antibiotic |
Used for | Infections (in adults and children) |
Also called | Penicillin V |
Available as | Tablets and oral liquid medicine |
What is phenoxymethylpenicillin used for?
Phenoxymethylpenicillin is a type of penicillin antibiotic used to treat infections such as chest infections, tonsillitis, cellulitis, ear infections, and dental abscesses.
It is used in particular for respiratory infections in children. You may also be prescribed phenoxymethylpenicillin to protect against infection if (for example) you have had rheumatic fever, or if you have sickle-cell disease, or if you have had your spleen removed.
Phenoxymethylpenicillin works by killing the germs that are causing the infection.
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Side effects of phenoxymethylpenicillin
The most common side effects of phenoxymethylpenicillin are:
Feeling sick (nausea).
Being sick (vomiting).
Stomach pain.
Diarrhoea.
Thrush.
Skin rash.
The best place to find a full list of the side effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine.
Speak with your doctor or pharmacist if any of the following continue or become troublesome.
How to manage phenoxymethylpenicillin side effects
Common phenoxymethylpenicillin side effects (these affect around 1 in 10 people) | What can I do if I experience this? |
Feeling sick or being sick, tummy (abdominal) pain | Stick to simple foods |
Diarrhoea | Drink plenty of water to replace any lost fluids. If the diarrhoea continues, becomes severe, or contains blood, let your doctor know straightaway |
Redness and itchiness (thrush) in the mouth or vagina | Speak with your doctor or pharmacist for advice about treatment |
Skin rash, and other allergic-type reactions | Let your doctor know as soon as possible as your treatment may need to be changed |
Important: if you develop an itchy rash, swollen face or mouth, or have difficulty breathing, these could be signs that you are allergic to a penicillin antibiotic.
Do not take any more phenoxymethylpenicillin, and speak with your doctor or go to your local accident and emergency department straightaway.
If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist for further advice.
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Who should not take phenoxymethylpenicillin?
Some medicines are not suitable for people with certain conditions. Before starting phenoxymethylpenicillin let your doctor or dentist know about any of the following:
If you have an allergic condition (such as asthma, eczema, or hay fever), or if you have ever had an allergic reaction to a medicine. This is especially important if you have ever had a bad reaction to any penicillin antibiotic.
If you are pregnant or breastfeeding (although phenoxymethylpenicillin is not known to be harmful to babies).
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
How to take phenoxymethylpenicillin
Read the leaflet in the pack before starting phenoxymethylpenicillin. It explains how to take it and lists possible side effects.
Take phenoxymethylpenicillin exactly as prescribed. For short-term infections, take it four times a day; for long-term prevention, take one or two doses daily.
Your doctor or pharmacist will tell you what dose is right for you to take, and the full directions will also be printed on the label of the pack to remind you about what was said to you.
It is important that you space out the doses evenly during the day.
If you have been given liquid medicine for a child, read the directions carefully to make sure you measure out the correct amount of medicine.
Take phenoxymethylpenicillin on an empty stomach - 1 hour before or 2 hours after eating - so your body can absorb it properly.
If you forget to take a dose at your usual time, take it as soon as you remember. Try to take the correct number of doses each day, but do not take two doses at the same time to make up for a forgotten dose.
Getting the most from your treatment
Finish the full course of phenoxymethylpenicillin, even if you feel better, unless your doctor tells you to stop.
Treatment usually lasts 7–10 days. If you’re still unwell after finishing, see your doctor. For long-term prevention, take it as prescribed.
Thrush (in the mouth or vagina) can occur after antibiotics - speak to your doctor or pharmacist if this happens.
This antibiotic can stop the oral typhoid vaccine from working. If you are due to have any vaccinations, make sure the person treating you knows that you are taking this medicine.
How to store phenoxymethylpenicillin
Keep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
If you have been given liquid medicine, store it in a refrigerator. It will have been made up by the pharmacy and lasts for seven days, so check the expiry date on the bottle and do not use it after this date.
Important information about all medicines
Important information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.
If you are having an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
MHRA - Reporting adverse reactions
Report suspected side effects to medicines, vaccines, e-cigarettes, medical device incidents, defective or falsified (fake) products to the Medicines and Healthcare products Regulatory Agency to ensure safe and effective use.
Frequently asked questions
Can I drink alcohol on phenoxymethylpenicillin?
Yes, you can usually drink alcohol while taking phenoxymethylpenicillin. Alcohol does not directly interfere with how the medicine works, but drinking may make side effects like stomach upset or dizziness feel worse.
Will taking phenoxymethylpenicillin affect my contraception?
Phenoxymethylpenicillin does not usually affect hormonal contraception. You can continue using the pill, patch or coil as normal while taking this antibiotic. If you are concerned, speak to your doctor or pharmacist for reassurance.
Can I drive or ride a bike whilst taking phenoxymethylpenicillin?
Yes, you can usually drive or ride a bike while taking phenoxymethylpenicillin. The antibiotic does not normally affect your ability to drive.
Is phenoxymethylpenicillin stronger than amoxicillin?
No, phenoxymethylpenicillin is not generally considered stronger than amoxicillin. Amoxicillin is usually preferred for a wider range of infections because it is absorbed better and works against more types of bacteria. Phenoxymethylpenicillin is still effective, but it is typically used for more specific infections, such as strep throat.
Further reading and references
- Manufacturer's PIL, Phenoxymethylpenicillin 125 mg/5 ml and 250 mg/5 ml Oral Solution; Flamingo Pharma (UK) Ltd, The electronic Medicines Compendium. Dated July 2020.
- Manufacturer's PIL, Phenoxymethylpenicillin 250 mg film-coated tablets; Brown and Burk UK Ltd, The electronic Medicines Compendium. Dated May 2015.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 18 Dec 2025
19 Dec 2022 | Latest version

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