Rabeprazole reduces the amount of acid produced in your stomach.
Swallow the tablet whole - do not chew or crush it before you swallow.
Any side-effects are usually mild in nature and do not last for long.
|Type of medicine||Proton pump inhibitor|
|Used for||Gastric and duodenal ulcers; gastro-oesophageal reflux disease; Helicobacter pylori infection; Zollinger-Ellison syndrome|
Acid is produced naturally in your stomach to help you digest food and to kill germs (bacteria). This acid is irritant so your body produces a natural mucous barrier which protects the lining of your stomach. In some people, this barrier can break down allowing the acid to damage the stomach, causing inflammation, ulcers and other conditions. Other people can have a problem with the muscular band at the top of the stomach that keeps the stomach tightly closed. This may allow the acid to escape and irritate the oesophagus, causing heartburn. This is often referred to as 'acid reflux'.
Proton pump inhibitors such as rabeprazole stop cells in the lining of the stomach from producing too much acid. This helps to prevent ulcers from forming, or assists the healing process where damage has already occurred. By decreasing the amount of acid, they can also help to reduce the symptoms of acid reflux disease, such as heartburn.
Rabeprazole is also used as one part of a treatment to get rid of Helicobacter pylori, a bacterium found in the stomach, which can cause ulcers.
Before taking rabeprazole
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking rabeprazole it is important that your doctor knows:
- If you are pregnant, trying for a baby or breastfeeding.
- If you have any of the following symptoms: difficulty swallowing, loss of blood, weight loss, or if you are being sick.
- If you have any problems with the way your liver works.
- If you have weakened bones due to osteoporosis or you are at risk of developing osteoporosis.
- If you have any problems with the way your body absorbs certain vitamins or minerals from your food.
- If you have an inflammatory condition called systemic lupus erythematosus (also called lupus, or SLE).
- If you have ever had an allergic reaction to a medicine.
- If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
How to take rabeprazole
- Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about rabeprazole and will provide you with a full list of the side-effects which you may experience from taking it.
- Take rabeprazole exactly as your doctor tells you to. Rabeprazole is commonly taken just once a day, in the morning. If you are taking it for either Helicobacter pylori eradication or for Zollinger-Ellison syndrome, you could be asked to take two doses a day. Your doctor will tell you which dose is right for you, and the directions will also be printed on the label of the pack to remind you about what the doctor said.
- Swallow the tablet with a drink of water. Do not chew, crush or break the tablet before you swallow. Rabeprazole tablets have a special coating so you should swallow them whole.
- Rabeprazole can be taken either before or after food, although taking it before food is preferable.
- If you forget to take a dose at your usual time, you can generally take it when you remember. However, if it is nearly time to take your next dose when you remember, leave out the missed dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
Getting the most from your treatment
- Try to keep your regular appointments with your doctor. This is so your progress can be checked. If you are taking rabeprazole on a long-term basis your doctor will want to review your treatment at least once a year to make sure it is still right for you.
- A typical course of treatment lasts for one or two weeks if you are taking rabeprazole for Helicobacter pylori eradication. It will last for one or two months if it is to allow an ulcer to heal. For all other reasons for taking rabeprazole, your treatment will last for as long as is necessary to control your symptoms.
- Some foods may make your symptoms worse. Foods and drinks that have been suspected of this include peppermint, tomatoes, chocolate, spicy foods, hot drinks, coffee and alcoholic drinks. If it seems that a food is aggravating your symptoms, try avoiding it for a while to see if your symptoms improve. Also, try avoiding eating large meals, as these can make your symptoms worse too.
- If you are overweight, it puts extra pressure on your stomach and encourages the symptoms of acid reflux. Losing some weight and eating a healthy balanced diet may help you.
- Smoking increases the amount of acid produced by the stomach and may make your symptoms worse. If you are a smoker, speak with your doctor or pharmacist about how to quit.
- Recent studies suggest that there may be a slight increase in the risk of bone fractures when proton pump inhibitors like rabeprazole are taken for longer than a year. If this affects you, your doctor will check that you are taking enough vitamin D and calcium to reduce this risk.
- If you buy any medicines 'over the counter', always check with a pharmacist that they are safe to take alongside your other medicines.
Can rabeprazole cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with rabeprazole. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
|Common rabeprazole side-effects (these affect fewer than 1 in 10 people)||What can I do if I experience this?|
|Headache||Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know|
|Feeling dizzy or tired||Getting up or moving more slowly may help dizziness. Do not drive and do not use tools or machines until you feel better|
|Feeling sick (nausea), stomach ache, or wind||Stick to simple meals - avoid rich or spicy foods|
|Diarrhoea||Drink plenty of water. If it continues or becomes severe, let your doctor know|
|Constipation||Try to eat a well-balanced diet and drink several glasses of water each day|
|Flu-like infections, cough, runny or stuffy nose, difficulty sleeping, and back pain||If any of these become troublesome, speak with your doctor|
Important: in very rare cases rabeprazole has caused a skin condition called cutaneous lupus erythematosus (CLE). See your doctor if you develop a blistering skin rash together with joint pain, either during or after treatment with rabeprazole.
If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.
How to store rabeprazole
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
Important information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
If you are having an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Further reading and references
Manufacturer's PIL, Pariet® 10 mg and 20 mg Tablets; Eisai Limited, The electronic Medicines Compendium. Dated May 2020.
British National Formulary, 81st Edition (Mar 2021); British Medical Association and Royal Pharmaceutical Society of Great Britain, London.