Treosulfan
Peer reviewed by Sid DajaniLast updated by Michael Stewart, MRPharmSLast updated 23 Aug 2024
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Clinical author's note
Michael Stewart 24/08/2024: Treosulfan 250 mg capsules have been discontinued in the United Kingdom. At the time of review there are no branded or generic tablets or capsules containing treosulfan available in the UK. Treosulfan is still available as a solution for infusion, administered in hospital. The information in this leaflet may still be relevant if you are being treated with treosulfan infusions. Please read the information given to you by your hospital and refer to any manufacturer's information supplied with your medicine.
Treosulfan will be prescribed for you by a specialist doctor.
Please keep your regular appointments with your doctor or hospital. You will need to have frequent blood tests.
If you think you are getting an infection or if you have a high temperature, please see your doctor straightaway.
At a glance
Treosulfan is a chemotherapy medicine used to treat ovarian cancer in women.
It works by preventing cancer cells from multiplying.
Your doctor will prescribe it, often with other treatments.
You must tell your doctor if you are pregnant, breastfeeding, have an infection, or other conditions.
Drink plenty of fluid and pass urine frequently during treatment.
Treosulfan can lower your resistance to infection, so avoid people with infections.
Report a sore throat or high temperature to your doctor immediately.
Do not get pregnant during treatment and for six months after.
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About treosulfan
Type of medicine | An alkylating chemotherapy medicine |
Used for | Cancer of the ovaries |
Available as | Capsules (discontinued) and injection |
Treosulfan is used to treat ovarian cancer in women. In cancer, certain cells in your body grow and multiply too fast. Chemotherapy medicines like treosulfan work by preventing cells from multiplying. This reduces the number of cancer cells made.
Treosulfan may be given alongside other medicines or treatments to help treat your condition.
Before taking treosulfan
Back to contentsSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking treosulfan it is important that your doctor knows:
If you are pregnant or breastfeeding.
If you have an infection or feel unwell.
If you have a rare inherited blood condition called porphyria.
If you have ever had an allergic reaction to a medicine.
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
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How to take treosulfan
Back to contentsBefore you start this treatment, read any printed information you have been given by your doctor and the printed manufacturer's leaflet. These will give you more information about treosulfan and will provide you with a full list of the side-effects which you may experience from having treatment.
Treosulfan will be prescribed for you by a specialist doctor who is experienced in treating your condition.
While you are having treosulfan treatment, it is important that you drink plenty of fluid and that you pass urine frequently. Drinking lots of water and other fluids will help prevent a serious type of cystitis sometimes caused by this medicine.
Getting the most from your treatment
Back to contentsYou must try to keep your regular appointments with your doctor or hospital. This is so your doctor can check on your progress. You will need to have regular blood tests and check-ups during your treatment with treosulfan.
While you are having treosulfan and for six months after you have stopped the treatment, do not have any immunisations (vaccinations) without talking to your specialist doctor first. Treosulfan lowers your body's resistance and there is a risk that you will get an infection from some vaccines.
It is important that you do not get pregnant while you are having treosulfan. If appropriate, please discuss with your doctor which types of contraception are suitable for you and your partner.
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Can treosulfan cause problems?
Back to contentsMedicines used to treat cancer can have a number of side-effects, some of which can be delayed for several days or weeks after taking the medicine. Most chemotherapy medicines can lower the number of white cells in your blood, which increases the risk of you getting an infection. While you are taking treosulfan you should take precautions to reduce the risk of getting an infection - you can do this by avoiding being with people who you know have an infection. If you think you are getting a sore throat or if you have a high temperature, please let your doctor know as soon as possible so that you can get some treatment straightaway.
Your doctor will discuss with you the possibility of unwanted side-effects from your treatment, although not everyone experiences these. The table below contains some of the side-effects associated with treosulfan. You will find a full list in the manufacturer's information leaflet supplied with your medicine. Please let your doctor know if you experience any of the following:
Very common treosulfan side-effects (these affect more than 1 in 10 women) | What can I do if I experience this? |
A high temperature (fever), or symptoms of an infection | Let your doctor know about this straightaway |
Feeling sick (nausea) or being sick (vomiting) | Stick to simple meals - avoid rich or spicy food. If this becomes troublesome, let your doctor know, as you can be prescribed an anti-sickness medicine |
Some loss of hair; a bronze skin colouration | Discuss these with your doctor if you are concerned |
Rare treosulfan side-effects | What can I do if I experience this? |
A burning feeling as you pass urine, blood in your urine | Continue to drink plenty of water and try to pass urine frequently. If you notice blood in your urine, please let your doctor know straightaway |
Feeling short of breath | Let your doctor know about this straightaway. It could be a sign of a rare but serious lung condition |
If you experience any other symptoms which you think may be due to the capsules, please speak with your doctor or pharmacist for further advice.
How to store treosulfan
Back to contentsKeep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Important information about all medicines
Back to contentsImportant information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
If you buy any medicines, always check with a pharmacist that they are suitable for you to take with your prescribed medicines.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.

Unsure about mixing medicines?
Check for possible interactions between medicines, supplements and foods before taking them together.
Frequently asked questions
What happens if I miss an appointment during my treosulfan treatment?
It's very important to keep all your regular appointments with your doctor or hospital while on treosulfan. This allows your doctor to monitor your progress and conduct necessary blood tests and check-ups. If you miss an appointment, you should contact your clinic as soon as possible to reschedule.
Are there any specific foods or drinks I should avoid while on treosulfan?
The article mentions that if you experience feeling sick or being sick, you should stick to simple meals and avoid rich or spicy food. It does not mention any other specific food or drink restrictions.
How can I tell if a high temperature or feeling unwell is a side effect of treosulfan or a sign of infection?
A high temperature (fever) or symptoms of an infection are listed as very common side-effects of treosulfan. Since treosulfan lowers your body's resistance and increases the risk of infection, it's crucial to let your doctor know straightaway if you experience these symptoms, so they can determine the cause and provide appropriate treatment.
Can treosulfan make my skin sensitive to the sun?
The article mentions a bronze skin colouration as a possible side effect of treosulfan. However, it does not specifically state that treosulfan makes your skin more sensitive to the sun. If you are concerned about this side effect, you should discuss it with your doctor.
What should I do if I think I've taken too much treosulfan?
If you suspect that you or someone else might have taken an overdose of treosulfan, you should go to the accident and emergency department of your local hospital immediately. Remember to take the medicine container with you, even if it is empty.
Further reading and references
- Medicines Complete BNF 89th Edition; British Medical Association and Royal Pharmaceutical Society of Great Britain, London.
- Manufacturer's information for healthcare professionals: Summary of medicinal Product Characteristics (SmPC), Trecondi 1g powder for solution for infusion; The electronic Medicines Compendium. Dated April 2024.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 25 Aug 2027
23 Aug 2024 | Latest version

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