PatientPlus articles are written by UK doctors and are based on research evidence, UK and European Guidelines. They are designed for health professionals to use, so you may find the language more technical than the condition leaflets.
Synonyms: Pott's syndrome, Pott's caries, Pott's curvature, angular kyphosis, kyphosis secondary to tuberculosis, tuberculosis of the spine, tuberculous spondylitis and David's disease
Pott's disease is named after Percival Pott (1714-1788) who was a surgeon in London. Pott's disease is tuberculosis of the spinal column (must not be confused with Pott's fracture of the ankle).
- The usual sites to be involved are the lower thoracic and upper lumbar vertebrae.
- The source of infection is usually outside the spine. It is most often spread from the lungs via the blood.
- There is a combination of osteomyelitis and infective arthritis.
- Usually more than one vertebra is involved. The area most affected is the anterior part of the vertebral body adjacent to the subchondral plate. Tuberculosis may spread from that area to adjacent intervertebral discs.
- In adults, disc disease is secondary to the spread of infection from the vertebral body but in children it can be a primary site, as the disc is vascular in children.
- It is the most common place for tuberculosis to affect the skeletal system although it can affect the hips and knees too.
- The infection spreads from two adjacent vertebrae into the adjoining disc space.
- If only one vertebra is affected, the disc is normal, but if two are involved the disc between them collapses, as it is avascular and cannot receive nutrients.
- Caseation occurs, with vertebral narrowing and eventually vertebral collapse and spinal damage. A dry soft tissue mass often forms and superinfection is rare.
- Pott's disease is rare in the UK but in developing countries it represents about 50% of musculoskeletal tuberculosis.
- Tuberculosis worldwide accounts for 1.7 billion infections, and 2 million deaths per year.
- Over 90% of tuberculosis occurs in poorer countries, but a global resurgence is affecting richer ones.
- India, China, Indonesia, Pakistan and Bangladesh have the largest number of cases but there has been a marked increase in the number of cases in the former Soviet Union and in sub-Saharan Africa in parallel with the spread of HIV.
- About two thirds of affected patients in developed countries are immigrants.
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- The onset is gradual.
- Back pain is localised.
- Fever, night sweats, anorexia and weight loss.
- Signs may include kyphosis (common) and/or a paravertebral swelling.
- Affected patients tend to assume a protective upright, stiff position.
- If there is neural involvement there will be neurological signs.
- A psoas abscess may present as a lump in the groin and resemble a hernia:
- A psoas abscess most often originates from a tuberculous abscess of the lumbar vertebra that tracks from the spine inside the sheath of the psoas muscle.
- Other causes include extension of renal sepsis and posterior perforation of the bowel.
- There is a tender swelling below the inguinal ligament and they are usually apyrexial.
- The condition may be confused with a femoral hernia or enlarged inguinal lymph nodes.
- Spinal tuberculosis in children needs a particularly high index of suspicion for diagnosis.
- Pyogenic osteitis of the spine.
- Spinal tumours.
- Elevated ESR.
- Strongly positive Mantoux skin test.
- Spinal X-ray may be normal in early disease, as 50% of the bone mass must be lost for changes to be visible on X-ray. Plain X-ray can show vertebral destruction and narrowed disc space.
- MRI scanning may demonstrate the extent of spinal compression and can show changes at an early stage. Bone elements visible within the swelling, or abscesses, are strongly suggestive of Pott's disease rather than malignancy.
- CT scans and nuclear bone scans can also be used but MRI is best to assess risk to the spinal cord.
- A needle biopsy of bone or synovial tissue is usual. If it shows tubercle bacilli this is diagnostic but usually culture is required. Culture should include mycology.
- All patients with non-respiratory tuberculosis should have a CXR to exclude or confirm co-existing respiratory tuberculosis.
- Tuberculosis co-infection with HIV has become common. It is up to 11% in some areas of the UK and over 60% in countries such as Zambia, Zimbabwe and South Africa.
- In the developed world, the disease is more common in certain sections of society, such as alcoholics, the undernourished, ethnic minority communities and the elderly.
- The disease is also more common in patients after gastrectomy for peptic ulcer.
- The most common area affected is T10 to L1.
- The lower thoracic region is the most common area of involvement at 40-50%, with the lumbar spine in a close second place at 35-45%.
- The cervical spine accounts for about 10%.
- Medical treatment is the mainstay but surgical intervention may be required.
- Immobilisation of the spine is usually for two or three months.
- Drug treatment: this is covered in the separate article on the Management of Tuberculosis. Therapy may need to exceed six months.
Most patients affected by spinal tuberculosis can be successfully treated conservatively with chemotherapy, external bracing and prolonged rest. However, kyphotic deformity, spinal instability and neurological deficit are often associated with a conservative approach.
- A Cochrane review found that routine surgery in addition to chemotherapy had not been shown to improve outcome but the problem was that the evidence was poor.
- A study from India suggested that surgery is not mandatory.
- In patients with spinal tuberculosis, anterior spinal fusion should be considered if there is spinal instability or evidence of spinal cord compression.
- Patients who present with a kyphosis of 60° or more (or a kyphosis which is likely to progress) require anterior decompression, posterior shortening, posterior instrumented stabilisation and anterior and posterior bone grafting in the active stage of the disease.
- Progressive bone destruction leads to vertebral collapse and kyphosis:
- The spinal canal can be narrowed by abscesses, granulation tissue, or direct dural invasion. This leads to spinal cord compression and neurological signs (Pott's paralysis).
- Kyphosis occurs because of collapse in the anterior spine and can be severe.
- Lesions in the thoracic spine have a greater risk of kyphosis than those in the lumbar spine.
- Neurological problems can be prevented by early diagnosis and prompt treatment. It can reverse paralysis and minimise disability.
- A combination of conservative management and surgical decompression gives success in most patients.
- Late-onset paraplegia is best avoided by prevention of the development of severe kyphosis.
- Patients with tuberculosis of the spine who are likely to have severe kyphosis should have surgery in the active stage of disease.
- A cold abscess can occur if the infection extends to adjacent ligaments and soft tissues. Abscesses in the lumbar region may descend down the sheath of the psoas to the femoral trigone region and eventually erode into the skin and form sinuses.
- The progress is slow and lasts for months or even years.
- Prognosis is better if caught early and modern regimes of chemotherapy are more effective.
- A study from London showed that diagnosis can be difficult and is often late.
Further reading & references
- Tuberculosis; NICE CKS, January 2009
- Immunisation against infectious disease - the Green Book (latest edition); Public Health England
- Percivall Pott; Whonamedit.com
- Shikhare SN, Singh DR, Shimpi TR, et al; Tuberculous osteomyelitis and spondylodiscitis. Semin Musculoskelet Radiol. 2011 Nov;15(5):446-58. doi: 10.1055/s-0031-1293491. Epub 2011 Nov 11.
- Cormican L, Hammal R, Messenger J, et al; Current difficulties in the diagnosis and management of spinal tuberculosis. Postgrad Med J. 2006 Jan;82(963):46-51.
- Eisen S, Honywood L, Shingadia D, et al; Spinal tuberculosis in children. Arch Dis Child. 2012 Aug;97(8):724-9. doi: 10.1136/archdischild-2011-301571. Epub 2012 Jun 25.
- Tuberculosis; NICE Clinical Guideline (March 2011)
- Chandra SP, Singh A, Goyal N, et al; Analysis of changing paradigms of management in 179 patients with spinal tuberculosis over a 12-year period and proposal of a new management algorithm. World Neurosurg. 2013 Jul-Aug;80(1-2):190-203. doi: 10.1016/j.wneu.2012.12.019. Epub 2013 Jan 22.
- Pola E, Rossi B, Nasto LA, et al; Surgical treatment of tuberculous spondylodiscitis. Eur Rev Med Pharmacol Sci. 2012 Apr;16 Suppl 2:79-85.
- Jutte PC, van Loenhout-Rooyackers JH; Routine surgery in addition to chemotherapy for treating spinal tuberculosis. Cochrane Database Syst Rev. 2006 Jan 25;5:CD004532. doi: 10.1002/14651858.CD004532.pub2.
- Nene A, Bhojraj S; Results of nonsurgical treatment of thoracic spinal tuberculosis in adults. Spine J. 2005 Jan-Feb;5(1):79-84.
- Jain AK; Tuberculosis of the spine: a fresh look at an old disease. J Bone Joint Surg Br. 2010 Jul;92(7):905-13. doi: 10.1302/0301-620X.92B7.24668.
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Dr Richard Draper
Dr Colin Tidy
Dr John Cox