Liquid nitrogen treatment
Peer reviewed by Dr Philippa Vincent, MRCGPLast updated by Dr Rosalyn Adleman, MRCGPLast updated 8 Apr 2025
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Liquid nitrogen is extremely cold. It will freeze any living tissue it comes into contact with. Applying small amounts of liquid nitrogen to various skin problems is now a standard treatment. The medical term for this treatment is cryotherapy.
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What is liquid nitrogen used for?
Liquid nitrogen treats:
Skin tags.
Small fleshy growths.
Similar small 'lumps and bumps' on the skin
These are ideal for liquid nitrogen treatment.
Is liquid nitrogen treatment painful?
Applications usually last about 10-30 seconds. Try holding a cube of ice against your skin for 10-30 seconds. It is uncomfortable but usually not too painful. Liquid nitrogen applied to skin is similar but colder and most people find the discomfort quite bearable.
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What can I expect from liquid nitrogen treatment?
After a liquid nitrogen treatment, the lump, wart or whatever is being treated will gradually discolour and fall off.
The surrounding skin will sometimes become red and swollen and be sore for a day or so. It is similar to a mild burn.
Occasionally a blister (sometimes a 'blood blister') forms. If this happens, it is best to pop it with a clean pin and apply a plaster.
New skin quickly forms and any scab or blister will soon disappear. The appearance of the skin afterwards is usually good.
Does liquid nitrogen treatment always work?
Usually, it does. However, sometimes thicker warts or verrucas need two or more sessions of liquid nitrogen treatment over a period of a few weeks to get to the root.
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Further reading and references
- Kwok CS, Gibbs S, Bennett C, et al; Topical treatments for cutaneous warts. Cochrane Database Syst Rev. 2012 Sep 12;9:CD001781. doi: 10.1002/14651858.CD001781.pub3.
- Macaulay D; Liquid nitrogen for cryotherapy. Br J Gen Pract. 2012 Nov;62(604):572. doi: 10.3399/bjgp12X658214.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 7 Apr 2028
8 Apr 2025 | Latest version

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