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This article is for Medical Professionals

Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Headache article more useful, or one of our other health articles.

Treatment of almost all medical conditions has been affected by the COVID-19 pandemic. NICE has issued rapid update guidelines in relation to many of these. This guidance is changing frequently. Please visit https://www.nice.org.uk/covid-19 to see if there is temporary guidance issued by NICE in relation to the management of this condition, which may vary from the information given below.

This article represents an overview of primary and secondary headache types as defined by the International Headache Society. Further details on the epidemiology, presentation and management of each type is covered, where indicated, by linked articles.

Headache affects almost everyone at some time. It is more common in women than in men. The International Headache Society classifies headaches into primary and secondary headache disorders.[1, 2]

Over 90% of headaches seen in primary care are primary headaches.[3]The primary headaches consists of four categories, of which the first two are the most common. The four categories are:[2]

Tension-type headache (TTH)

See separate Tension-type Headache article.

  • These are the most common type of headaches. Estimated lifetime prevalence of episodic TTH has not been clearly measured. Figures of 30% to 78% are widely quoted but there are no published studies which support these numbers.
  • The classification includes both episodic and chronic TTH.
  • TTH characteristics are that they are bilateral, pressing or tightening in quality, mild-to-moderate in intensity and with no nausea. They are not aggravated by physical activity although there may be pericranial tenderness and sensitivity to light or noise.[1]


See separate Migraine article.

  • Migraine headaches tend to be unilateral, throbbing and disproportionately disabling. Nausea is common.
  • Migraine can occur with or without aura.
  • Visual symptoms are the most common manifestation of an aura and consist of flickering lights, spots or zig-zag lines, fortification spectra or blind spots.

Cluster headaches

See separate Cluster Headache article.

  • Cluster headaches are characterised by attacks of severe unilateral pain in a trigeminal distribution. They are more common in:
    • Men.
    • People who smoke.
    • Adults older than 20 years.
  • They occur in clusters followed by a remission period of months or years.
  • They often begin during sleep and may wake the patient, as the pain is severe. They are associated with ipsilateral watering of the eye, conjunctival redness, rhinorrhoea, nasal blockage and ptosis.

Other primary headaches

This is a heterogeneous group of headaches with poorly understood pathogenesis, whose currently established treatment is often based on anecdote or on uncontrolled trials. Some of them, such as primary thunderclap headache, will have significant and even life-threatening conditions such as subarachnoid haemorrhage (SAH) in the differential diagnosis, and will require imaging. The list of other primary headaches is as follows:

  • Primary stabbing headache (also called ice-pick headache): This consists of a single stab or series of stabs in the distribution of the first trigeminal nerve with no other accompanying signs or symptoms.
  • Primary cough headache (also called Valsalva headache): a headache precipitated by coughing or straining in the absence of any other headache disorder.
  • Primary exertional headache: this is a pulsating headache brought on by exercise and lasting 5 minutes to 48 hours. It occurs particularly in hot weather or at high altitude. Due to its sudden onset, SAH may need to be excluded. At altitude it is essential to consider acute mountain sickness and high-altitude cerebral oedema, and in view of their seriousness these should be the first-line diagnoses until disproved.
  • Primary sexual headache (benign vascular sexual headache or coital cephalgia): a headache precipitated by sexual activity, usually starting during intercourse and peaking at orgasm. It may have an explosive onset at orgasm, in which case SAH will need to be excluded at least on the first occurrence.
  • Primary thunderclap headache is a high-intensity headache of sudden onset reaching maximum intensity in under a minute and lasting from 1 hour to 10 days. It resembles SAH, from which it cannot be distinguished on clinical grounds alone. When such a headache presents in primary care, without other symptoms, there is a 1 in 10 chance that this represents SAH. Primary thunderclap headache is not recurrent, generally, although it may recur in the first week after onset:
    • Evidence that thunderclap headache exists as a primary condition is poor - the search for an underlying cause should be exhaustive, as the differential diagnoses are serious.
    • Thunderclap headache is frequently associated with serious vascular intracranial disorders, particularly SAH - it is mandatory to exclude this and a range of other such conditions including intracerebral haemorrhage, cerebral venous thrombosis, unruptured vascular malformation (mostly aneurysm), arterial dissection (intracranial and extracranial), CNS angiitis, reversible benign CNS angiopathy and pituitary apoplexy.
    • Other organic causes of thunderclap headache are colloid cyst of the third ventricle, CSF hypotension and acute sinusitis (particularly with barotrauma).[2]
  • Hypnic headache: this is a dull headache that wakens the patient from sleep, occurs on at least half of all days and lasts at least 15 minutes after waking. It affects those aged over 50 years only. There are no other signs or symptoms but intracranial disorders must be excluded.
  • Hemicrania continua: a persistent unilateral headache for three months or more, daily and continuous, of moderate intensity with exacerbations. These feature autonomic symptoms such as eye watering, ptosis and nasal congestion. The condition responds completely to indomethacin.
  • New daily persistent headache: this is a headache that is daily and unremitting virtually from onset. It can resemble TTH but may build to become severe. If nausea is present it is only mild, but photophobia or phonophobia can also occur. It is very difficult to treat.

See separate Secondary Headache article. These include:

Classifying headache type and reaching a diagnosis based on the features of the headache allows people with a primary headache disorder to receive appropriate treatment and prevention for their headaches. Some people will have more than one headache disorder and therefore have more than one classification. Accurate classification (and appropriate treatment) helps reduce referrals for unnecessary investigations and contribute to improved outcomes for people with a headache disorder.[5]

Consider using a headache diary to aid the diagnosis of primary headaches. Do not use a headache diary to delay investigation in patients with red flag symptoms.[1]If a headache diary is used, ask the person to record the following for a minimum of eight weeks:

  • Frequency, duration and severity of headaches.
  • Any associated symptoms.
  • All prescribed and over-the-counter medications taken to relieve headaches.
  • Possible precipitants.
  • Relationship of headaches to menstruation.

How many different headache types does the patient experience?

  • Separate histories are necessary for each headache
  • It is sensible to concentrate on the most troublesome to the patient, but always take full histories about the others in case there are red flags.

Timing questions

  • Why is the patient consulting now?
  • When did the headaches first start?
  • Any previous similar episodes in the past?
  • Are things getting worse, getting better or staying the same?
  • How frequent are they, and what temporal pattern (especially distinguishing between episodic and daily or unremitting)?
  • What is a typical headache like? How long do they last?
  • How severe are they? Scale of 1 to 10?

Character questions

  • What is the intensity of pain?
  • What is the nature and quality of pain - eg, dull, throbbing, stabbing?
  • Site and spread of pain?
  • Are there associated symptoms?

Cause questions

  • Are there predisposing or trigger factors?
  • Are there aggravating or relieving factors?
  • Is there any family history of similar headache?

Response questions

  • What does the patient do during the headache?
  • How much are activities limited or prevented?
  • What medication has been tried and how has it been used?

State of health between attacks

  • Completely well, or any residual or persisting symptoms?
  • Concerns, anxieties, fears about recurrent attacks or their cause?
  • What is the patient's medication history (paying particular attention to any newer medications)?

The onset of a new type of headache needs careful history taking and examination, keeping red flags in mind.

Most dangerous headaches suggest themselves by clues in the history and symptoms but even if the history sounds benign, a clinical examination is essential. This will reassure the patient that their problem has been fully assessed, exclude signs and explanatory features of secondary headache, and detect red flags (see below). If patients with headache are not thoroughly examined they are likely to feel that their worst fears have not been considered or excluded.

Conduct a general and then a focused examination, depending on the features of the headache described by the patient.

  • The optic fundi should always be examined.
  • Blood pressure measurement is recommended.
  • Temporal artery palpation is essential in patients aged over 50 years.
  • Perform a full neurological examination if focal neurological symptoms are present.
  • Assess and record cognitive level if this is in any way disturbed.

Additional physical examination may be suggested from the history - for example:

  • Fever and neck stiffness (meningitis).
  • Scalp or temporal artery tenderness (giant cell arteritis).
  • Examine the head and neck for muscle tenderness and stiffness.
  • Painful red eye with dilated pupil (primary angle-closure glaucoma).
  • Papilloedema (intracranial tumours, adult idiopathic intracranial hypertension).
  • Fever (infections, systemic illness).
  • Features of hypothyroidism.

General measures

Reassurance is part of successful management for most patients with headache.

Tension-type headache

See separate article Tension-type Headache.


See separate article Migraine Management.

Cluster headache

See separate article Cluster Headache.

Medication-overuse headache

See separate article Medication-overuse Headache and Headache Triggers.

The difficulty lies in separating the very many non-serious headaches, which may neverthless be severe, from the fewer but significant headaches, particularly those needing very urgent intervention. The following groups of symptoms and signs can be suggestive of headache of serious significance and in some cases suggest an urgent need for neuroimaging or other further investigation:[1]

Onset features

  • New onset of, or change in, headache in patients who are aged over 50 years.
  • Headache in patients who are aged under 5 years.
  • Thunderclap: rapid time to peak headache intensity (seconds to five minutes) - same-day specialist assessment required.
  • Headache waking the patient up (NB: migraine is the most frequent cause of morning headache).
  • Headache precipitated by physical exertion or Valsalva manoeuvre (eg, coughing, laughing, straining).
  • Headache onset with exertion or sex.

Neurological red flag features

  • Headache onset with seizure or syncope (SAH).
  • Headache associated with altered conscious level, memory loss, altered cognitive state or change in personality.
  • Focal neurological symptoms (eg, limb weakness, aura <5 minutes or >1 hour).
  • Non-focal neurological symptoms (eg, cognitive disturbance).
  • Abnormal neurological examination.

Headache features

  • First or worst headache of the patient's life.
  • Headache that changes with posture.

Associated features

  • Patients with risk factors for cerebral venous sinus thrombosis (including pregnancy).
  • Jaw claudication or visual disturbance.
  • New-onset headache in a patient with a history of HIV infection.
  • New-onset headache in a patient with a history of cancer which can metastasise to the brain (or any history of cancer in a patient aged under 20 years).
  • Symptoms suggestive of giant cell arteritis
  • Symptoms and signs of acute narrow-angle glaucoma.
  • Vomiting without any other obvious cause.
  • Headache after head injury or within 90 days of head injury (subdural in the elderly).
  • Papilloedema.
  • Immunosuppression.
  • Headache associated with neurological deficit.
  • Headache associated with visual disturbance or jaw claudication (temporal arteritis).
  • Abnormal physical findings.
  • Headache with fever, rash or neck stiffness

In one study, altered consciousness, altered neurology and papilloedema correlated particularly highly with positive neuroimaging findings.[6]In another study, age over 50 at diagnosis, altered consciousness and thunderclap headache correlated most highly with the occurrence of fatal headache.[7]

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Further reading and references

  1. Headaches in over 12s: diagnosis and management; NICE Clinical Guideline (September 2012, updated November 2015)

  2. International Headache Society Classification of Headaches ICHD II; Updated Web-based Version

  3. Hainer BL, Matheson EM; Approach to acute headache in adults. Am Fam Physician. 2013 May 1587(10):682-7.

  4. Diagnosis and Management of Migraine, Tension-Type, Cluster and Medication-Overuse Headache; British Association for the Study of Headache (BASH) Guidelines, (2010 - reviewed 2014)

  5. Headaches in young people and adults; NICE Quality Standards, Aug 2013

  6. M S, Lamont AC, Alias NA, et al; Red flags in patients presenting with headache: clinical indications for neuroimaging. Br J Radiol. 2003 Aug76(908):532-5.

  7. Lynch KM, Brett F; Headaches that kill: a retrospective study of incidence, etiology and clinical features in cases of sudden death. Cephalalgia. 2012 Oct32(13):972-8. Epub 2012 Aug 8.

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