Alcohol-related Problems

Authored by , Reviewed by Dr Laurence Knott | Last edited | Certified by The Information Standard

This article is for Medical Professionals

Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Alcoholism and Problem Drinking article more useful, or one of our other health articles.

See separate related articles Alcoholism and Alcohol Abuse - Recognition and Assessment and Alcoholism and Alcohol Abuse - Management.

The recommended maximum alcohol intake per week is 14 units for men and 14 units for women. In 2009, knowledge of daily benchmarks and measuring alcohol in units had increased among both men and women. The proportion of adults who had heard of daily benchmarks increased from 69% in 2006 to 90% in 2009.

The amount of alcohol consumed weekly by men in England in 2009 was 15.6 units, slightly lower than the previous year's estimate of 18 units. In women, the figures were 9.9 units in 2007, 7.7 units in 2008 and 9.9 units in 2009. This is thought to be due to differences in fluctuations in data analysis rather than any variance in real terms.

In 2013, more than one in five adults (21%) in Great Britain said they did not drink alcohol at all, an increase from 19% in 2005. The proportion of young adults who binged at least once a week fell from 18% in 2005 to 15% in 2013, and the proportion of young adults who drink frequently has fallen by more than two thirds since 2005. The risk for alcohol dependence increases with binge drinking. Generally, the falls in drinking between 2005 and 2013 were as a result of changes among younger adults, with little or no change in older groups.[1]

In 2012-13, there were an estimated 325,870 admissions where the primary diagnosis or external causes recorded in secondary care diagnosis fields were attributable to the consumption of alcohol.[2]

Moderate (12.5-<50 g/day) to heavy (>50 g/day) alcohol intake is associated with an increased risk of oesophageal cancer.[3]

Younger people were more likely than older people to exceed the daily benchmarks.[2]Among adults who had drunk alcohol in the previous week, 55% of men and 53% of women drank more than the recommended daily amounts, including 31% of men and 24% of women who drank more than twice the recommended amounts in 2012. In 2012, 43% of school pupils (aged 11-15) said that they had drunk alcohol at least once. This continues the downward trend since 2003, when 61% of pupils had drunk alcohol.

Having initially risen, the proportion of young women who drink heavily has fallen, although the statistics should be treated with caution due to the small sample size. The proportion of 16- to 24-year-old women who had drunk more than six units on at least one day in the previous week fell from 24% in 2009 to 17% in 2010.

Alcohol misuse accounted for 1.5% of all premature deaths in England in the UK. In 2012 there were 6,490 alcohol-related deaths. This is a 19% increase from 2001 (5,476) but a 4% decrease from 2011 (6,771).[2]

These result from continued use of excessive amounts of alcohol. Binge drinking and chronic drinking of alcohol are more likely to cause harm.[5]

Medical problems

  • Liver: alcoholic hepatitis, cirrhosis, liver cancer.
  • Gastrointestinal tract: oral cavity cancer, oesophageal neoplasm, oesophageal varices, pancreatitis.
  • Cardiovascular system: atrial fibrillation, hypertension, strokes and cardiomyopathy with heart failure.
  • Neurological system: acute intoxication with loss of consciousness, withdrawal, seizures, subdural haemorrhage, peripheral neuropathy, Wernicke-Korsakoff syndrome and cerebellar degeneration.

Psychiatric problems

  • Alcohol dependence syndrome
  • Suicidal ideation
  • Depression
  • Anxiety


  • Loss of libido
  • Fetal alcohol syndrome
  • Impaired performance at work.
  • Relationship problems.
  • Violent crimes - eg, domestic violence and drink driving offences.
  • Antisocial behaviour.

Effects of alcohol on the liver 

Alcoholic liver disease includes fatty liver, alcoholic hepatitis and cirrhosis. These three conditions probably represent a spectrum of liver damage resulting from continued abuse of alcohol.[6]

  • In fatty liver, there is an accumulation of fat within the hepatocytes. This is reversible with abstention from alcohol.
  • Alcoholic hepatitis presents as acute right upper quadrant (RUQ) pain with jaundice, fever and marked derangement of LFTs. At a microscopic level there is inflammation of the liver.
  • In liver cirrhosis, the hepatocytes are damaged so much that they are replaced by scar tissue which is permanent. Alcoholic hepatitis and cirrhosis may co-exist. Alcoholic hepatitis and cirrhosis may lead to encephalopathy, portal vein hypertension and hepato-renal syndrome. This group of patients is also at increased risk of infections and they are usually also malnourished.
  • Treatment involves good nutrition and abstinence from alcohol. There is no specific therapy for alcohol-related hepatitis and cirrhosis. It is important to look for and promptly treat the complications which include ascites, spontaneous bacterial peritonitis, hepatic encephalopathy and oesophageal varices.
  • Patients with ascites may need to be maintained on high doses of diuretics. Again, abstinence from alcohol is crucial.

See separate Cirrhosis article for more details.

Effects of alcohol on the gastrointestinal tract

Alcohol increases the risk of oral cancers. This is especially associated with spirits and the risk is increased with concomitant use of tobacco. Adenocarcinoma of the stomach and oesophagus are  thought to be related to alcohol use. Some of these cases may be genetically determined.[7]

Portal hypertension is a complication of cirrhosis and leads to a raised venous pressure in veins in the oesophagus and stomach. These swollen veins are superficial and bleed easily. Bleeding from oesophageal varices is serious and is associated with a high level of morbidity and mortality.[8]

Management of bleeding varices is a medical emergency and requires adequate resuscitation (patients may need to be intubated to protect their airway). Blood transfusions are necessary and correction of abnormal clotting with vitamin K and fresh frozen plasma (FFP) may also be required. Various options for treatment are available including vasoactive drugs, obturation with glue and balloon tube tamponade.

See separate Oesophageal Varices article for more details.

Both acute and chronic pancreatitis are associated with excessive alcohol consumption. One study found that consumption of spirits was more likely than wine or beer to cause acute pancreatitis.[4]The pathophysiology of alcohol-related pancreatitis is not clearly understood. Patients usually present with epigastric pain with vomiting. The amylase is high in acute pancreatitis but may be normal in patients with chronic pancreatitis. Pancreatitis can be associated with a number of complications such as shock, sepsis and abscess formation. Long-term complications include diabetes mellitus and weight loss from steatorrhoea.

See separate Acute Pancreatitis and Chronic Pancreatitis articles for more details.

Effects of alcohol on the cardiovascular system

  • Excessive alcohol use is associated with hypertension and subsequent target organ damage such as strokes, myocardial events and chronic kidney disease.[9]
  • It is also associated with a dilated cardiomyopathy with heart failure and atrial fibrillation which may revert to sinus rhythm.[10]

Again, abstinence from alcohol is paramount.

Effects of alcohol on the nervous system[11]

  • Acute alcohol intoxication can present with blackouts, head injuries and subdural haemorrhages. Alcohol withdrawal is associated with fits which may be unresponsive to anti-epileptics.
  • The Wernicke-Korsakoff syndrome results from lack of thiamine (commonly seen in alcoholics, due to malnutrition). Wernicke's syndrome occurs acutely and patients present with confusion, visual impairment (diplopia) and ataxia. Korsakoff's syndrome occurs more chronically and is characterised by memory deficits and confabulation .
  • Young people may be especially at risk of alcohol-induced brain impairment.[12]

See separate Wernicke-Korsakoff Syndrome article for more details.

Alcohol withdrawal occurs within a few hours of not having a drink and can last beyond 48 hours. Patients experience hallucinations, anxiety and a coarse peripheral tremor. On examination, patients may be pyrexial, tachycardic and hypertensive. They may also develop seizures and auditory and visual hallucinations.

Delirium tremens is the severe end of the spectrum of alcohol withdrawal and consists of a severe form of the above symptoms; it may be associated with circulatory collapse and ketoacidosis.

See separate Acute Alcohol Withdrawal and Delirium Tremens article for more details.

This is characterised by the following:

  • A strong desire to drink.
  • Difficulty controlling alcohol intake.
  • Physiological withdrawal when intake is reduced.
  • Tolerance, such that increasing amounts are required to produce the same effect.
  • Harm resulting from continued alcohol use - eg, work or relationship problems.

Treatment of alcohol dependence includes education, support, counselling and controlled alcohol withdrawal. Patients may need to be admitted to hospital for detoxification.[13]

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Further reading and references

  1. Opinions and Lifestyle Survey, Adult Drinking Habits in Great Britain, 2013; Office for National Statistics

  2. Statistics on Alcohol: England - 2014; Health and Social Care Information Centre (HSCIC)

  3. Islami F, Fedirko V, Tramacere I, et al; Alcohol drinking and esophageal squamous cell carcinoma with focus on light-drinkers and never-smokers: a systematic review and meta-analysis. Int J Cancer. 2011 Nov 15129(10):2473-84. doi: 10.1002/ijc.25885. Epub 2011 Apr 7.

  4. Sadr Azodi O, Orsini N, Andren-Sandberg A, et al; Effect of type of alcoholic beverage in causing acute pancreatitis. Br J Surg. 2011 Nov98(11):1609-16. doi: 10.1002/bjs.7632. Epub 2011 Aug 3.

  5. Nichols M, Scarborough P, Allender S, et al; What is the optimal level of population alcohol consumption for chronic disease prevention in England? Modelling the impact of changes in average consumption levels. BMJ Open. 2012 May 302(3). pii: e000957. doi: 10.1136/bmjopen-2012-000957. Print 2012.

  6. Zhu H, Jia Z, Misra H, et al; Oxidative stress and redox signaling mechanisms of alcoholic liver disease: updated experimental and clinical evidence. J Dig Dis. 2012 Mar13(3):133-42. doi: 10.1111/j.1751-2980.2011.00569.x.

  7. Terry MB, Gammon MD, Zhang FF, et al; Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas. Cancer Causes Control. 2007 Nov18(9):1039-46. Epub 2007 Jul 31.

  8. Sarangapani A, Shanmugam C, Kalyanasundaram M, et al; Noninvasive prediction of large esophageal varices in chronic liver disease patients. Saudi J Gastroenterol. 2010 Jan-Mar16(1):38-42.

  9. Puddey IB, Beilin LJ; Alcohol is bad for blood pressure. Clin Exp Pharmacol Physiol. 2006 Sep33(9):847-52.

  10. Conen D, Tedrow UB, Cook NR, et al; Alcohol consumption and risk of incident atrial fibrillation in women. JAMA. 2008 Dec 3300(21):2489-96.

  11. Mukherjee S; Alcoholism and its effects on the central nervous system. Curr Neurovasc Res. 2013 Aug10(3):256-62.

  12. Hermens DF, Lagopoulos J, Tobias-Webb J, et al; Pathways to alcohol-induced brain impairment in young people: a review. Cortex. 2013 Jan49(1):3-17. doi: 10.1016/j.cortex.2012.05.021. Epub 2012 Jun 17.

  13. Alcohol-use disorders: diagnosis, assessment and management of harmful drinking and alcohol dependence; NICE Clinical Guideline (February 2011)

Hi, I've just joined hoping to get some advice about liver pain I've been having recently. 32 year old Male, have been drinking regularly since college. For the past say 5 years anyway I would drink...

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