Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Aortic Stenosis article more useful, or one of our other health articles.
Treatment of almost all medical conditions has been affected by the COVID-19 pandemic. NICE has issued rapid update guidelines in relation to many of these. This guidance is changing frequently. Please visit https://www.nice.org.uk/covid-19 to see if there is temporary guidance issued by NICE in relation to the management of this condition, which may vary from the information given below.
What is aortic stenosis?
The normal aortic valve is composed of three thin cusps that project from the wall at the origin of the aorta. Aortic stenosis (AS) refers to a tight valve. Aortic sclerosis is usually considered to be the precursor of calcified, degenerative AS but sclerosis is rather more common than stenosis.
Who gets aortic stenosis?(Epidemiology)
- Aortic stenosis has become the most frequent type of valvular heart disease in Europe and North America. It most often presents as calcific AS in adults of advanced age (2-7% of the population aged over 65 years) .
- Aortic stenosis occurs in almost 10% of adults over the age of 80 years, with a mortality rate about 50% at two years unless outflow obstruction is relieved .
- The second most frequent cause, which dominates in the younger age group, is congenital.
- Rheumatic AS has become rare in developed countries.
Aortic stenosis risk factors
A congenital bicuspid valve predisposes to both AS and regurgitation .
Presentation of aortic stenosis
See also the separate Heart Auscultation and Heart Murmurs in Children articles. Aortic valve stenosis is the most common form of valvular heart disease in the elderly population and occurs frequently in conjunction with coronary artery disease .
- Aortic stenosis symptoms include shortness of breath on exertion, angina, dizziness or syncope.
- The characteristic murmur may occasionally be faint and so the patient may present as having heart failure of unknown cause.
- The disappearance of the second aortic sound is specific to severe AS, although not a sensitive sign.
Aortic stenosis symptoms
- Even with a quite marked pressure gradient across the aortic valve, patients may be asymptomatic for many years but they may still be susceptible to sudden events.
- AS predisposes to angina and is a reason to auscultate the chest when a patient presents with angina.
- It can also cause syncope on exertion and even sudden death and so violent exertion should be avoided.
- Symptoms of congenital disease often appear between the ages of 10 and 20 years.
- The classic triad of chest pain, heart failure and syncope are found usually after the age of 50 years.
- Fatigue may be the presentation in children.
- Syncope, especially on exertion, may be caused by arrhythmia or the sudden onset of heart failure with decline in cardiac output.
Signs of aortic stenosis
- Examination of the pulse in significant AS reveals a slow-rising, flat character called pulsus parvus et tardus . Blood pressure will show a narrow pulse pressure (difference between systolic and diastolic pressures). In the elderly, a rigid aorta may make this sign less obvious.
- Examination of the cardiovascular system includes palpation of the cardiac apex. There may be a thrill. In regurgitation the left ventricle is enlarged as each beat has to pump the required cardiac output plus that which regurgitates. In AS the left ventricle hypertrophies as more force is required to eject the blood past a tight valve. In laminar flow, the resistance to flow is proportional to the 4th power of the radius so that a small reduction in calibre has a marked effect on resistance.
- Aortic stenosis murmur:
- A2 is soft in AS. In aortic sclerosis, A2 is normal or loud.
- Both conditions are associated with an early, harsh systolic murmur that is transmitted to the carotids. A similar murmur may occur without stenosis if turbulence is due to aortic aneurysm causing dilation of the proximal aorta. Such pathology may cause leakage from the valve too and with it an early diastolic murmur.
- The typical murmur of AS is a crescendo-decrescendo systolic ejection murmur shortly after the first heart sound that ends just before the second heart sound. It is a rough, low-pitched sound that is loudest at the base of the heart and most commonly heard in the second right intercostal space.
- If congestive heart failure leads to a fall in cardiac output, the murmur will be quieter.
- An ejection click may be present, especially with bicuspid valves. Ejection sounds are more obvious in children in whom the valves are more mobile than in older people.
- A fourth heart sound indicates left ventricular hypertrophy (LVH) in severe AS. If the left ventricle dilates and fails, a third heart sound may be heard.
Differential diagnosis of aortic stenosis
Other causes of murmurs that are, or appear to be, from the aortic valve include:
- Aortic sclerosis.
- Aortic regurgitation.
- Subacute bacterial endocarditis.
- Dilatation of the root of the aorta (may also lead to a leaking valve).
- Flow murmurs (turbulence from high cardiac output in anaemia, thyrotoxicosis and marked aortic regurgitation).
- Murmurs originating from the pulmonary valve with disease of that valve or atrial septal defect (the pulmonary and aortic areas are very close).
NB: flow murmurs can be normal in children and in neonates. Interpretation of cardiac sounds in children can be very difficult. Aortic valve disease is often not detected until the child is about 2 years old.
Referral for adults with aortic stenosis
Offer referral to a specialist to:
- Adults with moderate or severe valve disease of any type.
- Adults with bicuspid aortic valve disease of any severity (including mild valve disease).
Pregnant women and women considering pregnancy
Women with valve disease can have a pregnancy without complications.
Refer pregnant women or women who are considering a pregnancy to a cardiologist with expertise in the care of pregnant women, if they have any of the following:
- Moderate or severe valve disease.
- Bicuspid aortic valve disease of any severity (including mild disease) and associated aortopathy.
- A prosthetic valve. Refer whether they have symptoms or not.
Investigating aortic stenosis
- ECG may show evidence of LVH or left ventricular strain.
- CXR may show cardiac enlargement, calcification of the aortic ring or evidence of other disease. It is often normal except in advanced disease.
- Is the key diagnostic tool. It confirms the presence of AS, assesses the degree of valve calcification, left ventricular function and wall thickness, detects the presence of other associated valve disease or aortic pathology and provides prognostic information.
- Trans-oesophageal echocardiography should be considered when transthoracic echocardiography is of insufficient quality.
- Doppler echocardiography is the preferred technique for assessing AS severity.
- Exercise testing:
- Is contra-indicated in symptomatic patients with AS but it is recommended in physically active patients for unmasking symptoms and in the risk stratification of asymptomatic patients with severe AS.
- Exercise testing is safe in asymptomatic patients, provided it is performed under the supervision of an experienced physician while monitoring for the presence of symptoms, changes in blood pressure, and/or ECG changes.
- Multi-slice computerised tomography (MSCT) and cardiac magnetic resonance:
- Provide additional information on the assessment of the ascending aorta when it is enlarged.
- MSCT may be useful in quantifying the valve area and coronary calcification, which aids in assessing prognosis.
- MSCT has become an important diagnostic tool for evaluation of the aortic root, the distribution of calcium, the number of leaflets, the ascending aorta, and peripheral artery pathology and dimensions before undertaking transcatheter aortic valve implantation (TAVI) - see 'Management', below.
- Natriuretic peptides have been shown to predict symptom-free survival and outcome in normal and low-flow severe AS and may be useful in asymptomatic patients.
- It may still be necessary to undertake cardiac catheterisation to measure pressures across the valve to assess the severity of disease and the need for intervention.
- Coronary angiography may be indicated as part of the assessment of coronary artery disease.
- The risk factors for aortic sclerosis are similar to the risk factors for coronary heart disease and so similar investigations should be undertaken .
Aortic stenosis treatment and management
See also the separate Prevention of Infective Endocarditis article.
Patients with aortic stenosis should avoid heavy exertion. Symptomatic patients require early surgical intervention because no medical therapy for AS is able to improve outcome. Treatment of high surgical risk patients has been modified with the introduction of TAVI.
- The progression of degenerative AS is an active process, in many ways similar to atherosclerosis.
- Statin therapy should not be used in AS patients if the only purpose is to slow progression, as this has not been shown to be of any benefit.
- However, modification of atherosclerotic risk factors is strongly recommended. Aortic sclerosis and stenosis in the older age group, should be seen as a strong risk for coronary heart disease and appropriate steps should be taken.
- Patients who are unsuitable candidates for surgery or TAVI, or who are currently awaiting a surgical or TAVI procedure, may be treated with digoxin, diuretics, angiotensin-converting enzyme (ACE) inhibitors (or angiotensin-II receptor antagonists) if they experience heart failure symptoms.
- Co-existing hypertension should be treated. However, treatment should be carefully titrated to avoid hypotension and patients should be re-evaluated frequently.
- Maintenance of sinus rhythm is important, using anti-arrhythmic drugs as indicated.
Symptomatic aortic stenosis
Symptomatic severe aortic stenosis has a poor prognosis and early intervention is strongly recommended in all patients. The only exceptions are for those in whom intervention is unlikely to improve quality of life or survival due to severe comorbidities, or for those
with concomitant conditions associated with survival less than 1 year. Intervention is recommended in symptomatic patients with high gradient aortic stenosis, regardless of left ventricular ejection fraction (LVEF). However, management of patients with low-gradient aortic stenosis is more challenging
Asymptomatic aortic stenosis
Intervention is recommended in asymptomatic patients with severe aortic stenosis and impaired LV function of no other cause, and those who are asymptomatic during normal activities but develop symptoms during exercise testing.
Management of asymptomatic severe aortic stenosis is otherwise controversial and the decision to intervene requires careful assessment of the benefits and risks in an individual patient. In the absence of adverse prognostic features, watchful waiting has generally been recommended with prompt intervention at symptom onset.
The mode of intervention
The use of transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) as treatment options has allowed a substantial increase in the overall number of patients with aortic stenosis undergoing surgical or transcatheter intervention in the past decade. Rates of vascular complications, pacemaker implantation, and paravalvular regurgitation are consistently higher after TAVI, whereas severe bleeding, acute kidney injury, and new-onset AF are more frequent after SAVR.
Balloon aortic valvuloplasty may be considered as a bridge to TAVI or SAVR in patients with decompensated aortic stenosis and (when feasible) in those with severe aortic stenosis who require urgent high-risk non-cardiac surgery. The procedure carries significant risk of complications.
Monitoring when no current need for intervention
- Offer clinical review every 6 to 12 months, with an echocardiogram, to adults with asymptomatic severe valve disease if an intervention is suitable but not currently needed.
- Consider echocardiographic assessment every 3 to 5 years for adults with mild aortic stenosis.
For adults, the National Institute for Health and Care Excellence (NICE) recommends the following
Offer an intervention to adults with symptomatic severe heart valve disease. Consider referring adults with asymptomatic severe aortic stenosis for intervention, if suitable, if they have any of the following:
- Vmax (peak aortic jet velocity) more than 5 m/s on echocardiography.
- Aortic valve area less than 0.6 cm2 on echocardiography.
- Left ventricular ejection fraction (LVEF) less than 55%.
- B-type natriuretic peptide (BNP) or N-terminal proBNP (NT-proBNP) level more than twice the upper limit of normal.
- Symptoms unmasked on exercise testing.
Consider referring adults with symptomatic low-gradient aortic stenosis with LVEF less than 50% for intervention if during dobutamine stress echocardiography the aortic stenosis is shown to be severe by:
- A mean gradient across the aortic valve that increases to more than 40 mm Hg and
- An aortic valve area that remains less than 1 cm2.
Consider measuring aortic valve calcium score on cardiac CT if the severity of symptomatic aortic stenosis is uncertain. Offer enhanced follow-up (for example, more frequent reviews) and further assessment (for example, stress echocardiography) to monitor the need for intervention if mid-wall fibrosis is detected on cardiac MRI in adults with severe aortic stenosis.
Aortic valve replacement (AVR)
- AVR is the definitive therapy for severe AS.
- Early valve replacement is strongly recommended for all symptomatic patients with severe AS who are otherwise candidates for surgery.
- Sutureless AVR :
- Sutureless aortic valve replacement (SUAVR) is an alternative to conventional surgical aortic valve replacement.
- Access to the heart is usually made through a full- or mini-sternotomy, or right anterior thoracotomy. The diseased aortic valve is accessed and removed through a cut in the aorta. Bulky calcifications around the native aortic annulus are removed to achieve a smooth round annulus for valve implantation.
- The valve prosthesis with self-expanding or balloon expanding frame, loaded into a special delivery device, is deployed into the native annulus. Once in position the valve is released.
- NICE recommends that current evidence on the safety and efficacy of sutureless aortic valve replacement for aortic stenosis is adequate to support the use of this procedure.
- Management of asymptomatic severe AS is controversial. The decision to operate on asymptomatic patients requires careful weighing of the benefits against the risks.
- Pulmonary autograft replacement of the aortic valve (the Ross procedure) is a popular choice for AVR in infants and children but its use in adults remains controversial .
- The NICE guidelines state that current evidence supports the safety and efficacy of balloon valvuloplasty for aortic valve stenosis in adults and children .
- However, re-stenosis and clinical deterioration occur within 6-12 months in most patients.
- In adults, the procedure should only be used to treat patients who are unsuitable for surgery, as the efficacy is usually short-lived.
- In infants and children, critical AS is very rare and balloon valvuloplasty is usually used palliatively until the child is old enough to have valve replacement .
- TAVI can be performed under a general anaesthetic or under local anaesthetic with sedation, making it a consideration in patients who are unsuitable for surgical AVR.
- Balloon valvuloplasty of the aortic valve is performed, followed up by insertion of the specialised valve device. The whole procedure occurs under fluoroscopy and echocardiography guidance.
- The procedure is made easier by concomitant rapid pacing of the heart to 200 beats per minute.
- The procedure is of equal efficacy as surgical AVR in patients who are unsuitable for surgery.
- Reported 30-day mortality rates range from 5-15%. Approximately 1-2% of TAVI patients require immediate cardiac surgery for life-threatening complications. Reported one-year survival for TAVI ranges from 60-80%. Most survivors experience significant improvement of health status and quality of life.
Complications of TAVI
- Major bleeding from entry sites.
- Stroke or transient ischaemic attacks - there is a higher rate of these compared with surgical AVR.
- Ventricular tachyarrhythmias.
- Myocardial infarction.
- Aortic dissection.
- Cardiac tamponade.
- Postoperative aortic regurgitation and paravalvular leak[19, 20] .
For adults with aortic valve disease, NICE recommends the following :
- Offer surgery, if suitable (by median sternotomy or minimally invasive surgery), as first-line intervention for adults with severe aortic stenosis, aortic regurgitation or mixed aortic valve disease and an indication for surgery who are at low or intermediate surgical risk.
- TAVI is not cost effective for people at low or intermediate surgical risk at the current list price.
- Offer TAVI, if suitable, to adults with non-bicuspid severe aortic stenosis who are at high surgical risk or if surgery is unsuitable.
- Do not offer anticoagulation after surgical biological valve replacement unless there are other indications for anticoagulation. Consider aspirin, or clopidogrel if aspirin is not tolerated, after TAVI.
- Consider transcatheter or redo surgical intervention for adults with severe aortic degeneration of a biological prosthetic valve and symptoms .
Aortic stenosis complications
- Aortic valve disease will eventually lead to decompensation with raised end-diastolic pressure, increased pressure in the pulmonary system and congestive heart failure.
- Damaged valves are susceptible to infective endocarditis.
- Calcified AS may produce small systemic emboli. The effect will depend upon where they lodge.
- Sudden death occurs in fewer than 0.2% of patients per year.
Aortic stenosis prognosis
- The rate of progression of aortic stenosis varies widely.
- Women with aortic stenosis have higher mortality than men, resulting from late diagnosis and initial specialist assessment followed by less frequent and delayed referral for intervention.
- Sudden cardiac death is a frequent cause of death in symptomatic patients but appears to be rare in truly asymptomatic patients, even in very severe AS.
- In asymptomatic patients with severe AS, reported average event-free survival at two years ranges from 20% to more than 50%.
- Predictors of symptom development and adverse outcomes in asymptomatic patients are:
- Clinical: older age, presence of atherosclerotic risk factors.
- Echocardiography: valve calcification, peak aortic jet velocity, left ventricular ejection fraction (LVEF), rate of haemodynamic progression, increase in gradient with exercise, excessive LVH, and abnormal tissue Doppler parameters of systolic and diastolic LV function.
- Exercise testing: discovery of symptoms during exercise testing in physically active patients, particularly those younger than 70 years, predicts a very high likelihood of symptom development within 12 months.
- Elevated plasma levels of natriuretic peptides.
- As soon as symptoms occur, the prognosis of severe AS is very poor, with survival rates of only 15-50% at five years.
- After successful AVR, symptoms and quality of life are in general greatly improved.
- Long-term survival may be close to the age-matched general population in older patients.
- In younger patients, there is substantial improvement compared to conservative medical therapy but there is a lower survival compared to age-matched controls.
- Risk factors for late death include age, comorbidities, severe symptoms, LV dysfunction, ventricular arrhythmias and untreated co-existing coronary artery disease.
Further reading and references
Nishimura RA, Otto CM, Bonow RO, et al; 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014 Jun 10129(23):2440-92. doi: 10.1161/CIR.0000000000000029. Epub 2014 Mar 3.
Czarny MJ, Resar JR; Diagnosis and management of valvular aortic stenosis. Clin Med Insights Cardiol. 2014 Oct 198(Suppl 1):15-24. doi: 10.4137/CMC.S15716. eCollection 2014.
Ramaraj R, Sorrell VL; Degenerative aortic stenosis. BMJ. 2008 Mar 8336(7643):550-5.
Rashedi N, Otto CM; Aortic Stenosis: Changing Disease Concepts. J Cardiovasc Ultrasound. 2015 Jun23(2):59-69. doi: 10.4250/jcu.2015.23.2.59. Epub 2015 Jun 26.
Michelena HI, Prakash SK, Della Corte A, et al; Bicuspid aortic valve: identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium (BAVCon). Circulation. 2014 Jun 24129(25):2691-704. doi: 10.1161/CIRCULATIONAHA.113.007851.
Grimard BH, Safford RE, Burns EL; Aortic Stenosis: Diagnosis and Treatment. Am Fam Physician. 2016 Mar 193(5):371-8.
Paradis JM, Fried J, Nazif T, et al; Aortic stenosis and coronary artery disease: what do we know? What don't we know? A comprehensive review of the literature with proposed treatment algorithms. Eur Heart J. 2014 Aug 1435(31):2069-82. doi: 10.1093/eurheartj/ehu247. Epub 2014 Jun 26.
Maganti K, Rigolin VH, Sarano ME, et al; Valvular heart disease: diagnosis and management. Mayo Clin Proc. 2010 May85(5):483-500.
Heart valve disease presenting in adults: investigation and management; NICE guideline (November 2021)
Guidelines for the management of valvular heart disease; European Society of Cardiology (2021)
Sutureless aortic valve replacement for aortic stenosis; NICE Interventional Procedure Guidance, Aug 2018.
Yacoub MH, Klieverik LM, Melina G, et al; An evaluation of the Ross operation in adults. J Heart Valve Dis. 2006 Jul15(4):531-9.
Balloon valvuloplasty for aortic valve stenosis in adults and children; NICE Interventional Procedure Guidance, July 2004
Transcatheter aortic valve implantation for aortic stenosis; NICE Interventional Procedure Guidance, July 2017.
Oliemy A, Al-Attar N; Transcatheter aortic valve implantation. F1000Prime Rep. 2014 Oct 16:92. doi: 10.12703/P6-92. eCollection 2014.
Bax JJ, Delgado V, Bapat V, et al; Open issues in transcatheter aortic valve implantation. Part 1: patient selection and treatment strategy for transcatheter aortic valve implantation. Eur Heart J. 2014 Oct 735(38):2627-38. doi: 10.1093/eurheartj/ehu256. Epub 2014 Jul 25.
Bax JJ, Delgado V, Bapat V, et al; Open issues in transcatheter aortic valve implantation. Part 2: procedural issues and outcomes after transcatheter aortic valve implantation. Eur Heart J. 2014 Oct 735(38):2639-54. doi: 10.1093/eurheartj/ehu257. Epub 2014 Jul 25.
Smith CR, Leon MB, Mack MJ, et al; Transcatheter versus surgical aortic-valve replacement in high-risk patients. N Engl J Med. 2011 Jun 9364(23):2187-98. Epub 2011 Jun 5.
Kodali SK, Williams MR, Smith CR, et al; Two-year outcomes after transcatheter or surgical aortic-valve replacement. N Engl J Med. 2012 May 3366(18):1686-95. Epub 2012 Mar 26.
Athappan G, Patvardhan E, Tuzcu EM, et al; Incidence, predictors, and outcomes of aortic regurgitation after transcatheter aortic valve replacement: meta-analysis and systematic review of literature. J Am Coll Cardiol. 2013 Apr 1661(15):1585-95. doi: 10.1016/j.jacc.2013.01.047.
Werner N, Sinning JM; Aortic regurgitation after transcatheter aortic valve replacement. Circ J. 201478(4):811-8. Epub 2014 Mar 14.
Valve-in-valve TAVI for aortic bioprosthetic valve dysfunction; Interventional procedures guidance. June 2019.