Axillary Vein Thrombosis

Authored by , Reviewed by Dr Jacqueline Payne | Last edited | Certified by The Information Standard

This article is for Medical Professionals

Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Antiphospholipid Syndrome (Hughes' Syndrome) article more useful, or one of our other health articles.

Synonyms: Paget-von Schrötter disease, axillary subclavian deep vein thrombosis, upper-extremity deep vein thrombosis, upper-limb deep vein thrombosis, effort-induced thrombosis

Acute swelling and pain in the upper limb due to occlusion of the axillary and/or subclavian veins by thrombus. This may occur as a primary phenomenon or as a result of secondary factors such as the placement of an indwelling venous catheter, thrombophilia or thoracic outlet syndrome.

See also the separate Deep Vein Thrombosis article.

  • There is a low incidence of about 1 per 100,000 people per year. 4-10% of all deep vein thromboses (DVTs) occur in the upper extremity.
  • It is now more common due to the growing use of central venous cannulation in a variety of medical procedures[2]. It occurs in about 25% of patients who undergo prolonged central venous cannulation, although it is often not recognised.
  • About 80% of primary cases occur in the dominant arm. It is also seen in young, otherwise healthy, individuals who participate in repetitive upper limb exercises[3].
  • One study reported that patients who had an upper limb DVT were more likely to be younger and with a lower BMI[4]. However, a more recent literature review reported an age range of 49 to 65 years.

Risk factors[5]

  • The presence of a central venous catheter[4].
  • Venous compression in the thoracic outlet syndrome.
  • Malignancy.
  • Congenital thrombophilia, acquired coagulation defects.
  • Diabetes mellitus.
  • Smoking habit.
  • Intense sports activity.

Symptoms[6]

Symptoms can be intermittent, or can develop during a period of up to one week.

  • Patients tend to present with discomfort and swelling, associated with discolouration of the hand.
  • 3-36% of cases may lead to pulmonary embolism with features of pleuritic chest pain, breathlessness and haemoptysis.

Signs

  • Physical examination may show low-grade fever due to thrombus formation. Higher fevers are seen with septic thrombophlebitis or in patients with associated malignancy.
  • Oedema of the arm and hand - measure the biceps/forearm diameter at a fixed distance from an anatomical landmark.
  • Mild-to-moderate cyanosis of the hand.
  • Dilated superficial collateral veins may be seen over the chest and upper arm - may be the only indicator in central venous cannulation.
  • Fullness in the supraclavicular fossa and even a palpable cord of thrombosed vein.
  • Jugular vein may be distended.
  • Ultrasound (compression with either Doppler or colour Doppler) is recommended as the investigation of choice.
  • D-dimer testing is less useful than in lower-limb thrombosis, particularly in hospitalised patients with central venous catheters or malignancy.
  • In patients with suspected upper-extremity DVT in whom initial ultrasound is negative for thrombosis despite a high clinical suspicion of DVT, CT scan or magnetic resonance phlebography is recommended.
  • It is uncertain whether routine thrombophilic screening in patients with this condition is worthwhile. It is probably useful where it occurs idiopathically, with a family history of thrombosis or history of recurrent miscarriage or previous DVT.
  • Imaging investigations to detect thoracic outlet syndrome should depend on the degree of clinical suspicion of this cause.
  • In idiopathic cases one should consider investigations to look for an occult malignancy or thrombophilia.
  • Acute treatment with parenteral anticoagulation (low molecular weight heparin, fondaparinux, intravenous/subcutaneous unfractionated heparin) is recommended. Low molecular weight heparin or fondaparinux are preferred. Rivaroxaban and apixaban can also be used[8].
  • Anticoagulant therapy is recommended in preference to thrombolysis. Anticoagulation should be for a minimum of three months.
  • For patients who undergo thrombolysis, the same intensity and duration of anticoagulant therapy should be used as for those patients who do not undergo thrombolysis.
  • For those patients with upper-extremity DVT that is associated with a central venous catheter, it is recommended that the catheter should not be removed if it is functional and there is an ongoing need for the catheter.
  • If the catheter is not removed then anticoagulation should be continued as long as the central venous catheter remains but there should be a minimum of three months of treatment.
  • A trial of compression bandages or sleeves to reduce symptoms is recommended for post-thrombotic syndrome of the arm (chronic venous insufficiency that may cause pain, oedema, pigmentation, skin changes and venous ulcers).

The use of anticoagulant prophylaxis in patients who are acutely ill and those who undergo central venous catheterisation may prevent upper-extremity DVT. The efficacy of anticoagulant prophylaxis has not been clearly evaluated at present[4]. However, many patients are also at risk of lower-limb thrombosis, which warrants anticoagulant prophylaxis in its own right[1].

Associated with significant morbidity and mortality due to potential risks of pulmonary embolism, post-thrombotic syndrome and loss of vascular access.

  • About 10-20% develop pulmonary embolism[9].
  • Reported mortality rates have varied from 15-50%, largely dependent on the underlying cause[10].
  • Recurrent thrombosis affects between 2% and 5% of patients[1].
  • Post-thrombotic syndrome affects 13% (see 'Complications', below)[10].
  • Pulmonary embolism has been detected on radiological grounds in up to 20% of patients with upper-limb DVT (incidence is highest in untreated/catheter cases).
  • Phlegmasia caerulea dolens (PCD) may occur (rarely); there is arterial and venous compromise and a risk of gangrene.
  • Compartment syndrome.
  • Recurrent thrombosis.
  • Post-thrombotic syndrome - chronic upper-limb pain and swelling.
  • Stroke following paradoxical embolisation in cases with a patent foramen ovale.
  • Right ventricular failure.
  • Thoracic duct obstruction.
  • Chylous pleural or pericardial effusion.

Further reading and references

  • Stake S, du Breuil AL, Close J; Upper Extremity Deep Vein Thromboses: The Bowler and the Barista. Case Rep Vasc Med. 20162016:9631432. doi: 10.1155/2016/9631432. Epub 2016 Oct 9.

  • Huang CY, Wu YH, Yeh IJ, et al; Spontaneous bilateral subclavian vein thrombosis in a 40-year-old man: A case report. Medicine (Baltimore). 2018 Apr97(15):e0327. doi: 10.1097/MD.0000000000010327.

  1. Heil J, Miesbach W, Vogl T, et al; Deep Vein Thrombosis of the Upper Extremity. Dtsch Arztebl Int. 2017 Apr 7114(14):244-249. doi: 10.3238/arztebl.2017.0244.

  2. Lee JA, Zierler BK, Zierler RE; The risk factors and clinical outcomes of upper extremity deep vein thrombosis. Vasc Endovascular Surg. 2012 Feb46(2):139-44. doi: 10.1177/1538574411432145. Epub 2012 Feb 9.

  3. Roche-Nagle G, Ryan R, Barry M, et al; Effort thrombosis of the upper extremity in a young sportsman: Paget-Schroetter syndrome. Br J Sports Med. 2007 Aug41(8):540-1

  4. Spencer FA, Emery C, Lessard D, et al; Upper extremity deep vein thrombosis: a community-based perspective. Am J Med. 2007 Aug120(8):678-84.

  5. Garofalo R, Notarnicola A, Moretti L, et al; Deep vein thromboembolism after arthroscopy of the shoulder: two case reports and a review of the literature. BMC Musculoskelet Disord. 2010 Apr 811:65. doi: 10.1186/1471-2474-11-65.

  6. Sadeghi R, Safi M; Systemic thrombolysis in the upper extremity deep vein thrombosis. ARYA Atheroscler. 2011 Spring7(1):40-6.

  7. Guyatt GH, Akl EA, Crowther M, et al; Executive summary: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb141(2 Suppl):7S-47S. doi: 10.1378/chest.1412S3.

  8. Montiel FS, Ghazvinian R, Gottsater A, et al; Treatment with direct oral anticoagulants in patients with upper extremity deep vein thrombosis. Thromb J. 2017 Oct 315:26. doi: 10.1186/s12959-017-0149-x. eCollection 2017.

  9. Stein CM, McLeod A, Devine LA; Spontaneous deep vein thrombosis in the upper extremity of a 45-year-old woman. CMAJ. 2015 Sep 22187(13):990-3. doi: 10.1503/cmaj.140400. Epub 2014 Nov 3.

  10. Margey R, Schainfeld RM; Upper Extremity Deep Vein Thrombosis: The Oft-forgotten Cousin of Venous Thromboembolic Disease. Curr Treat Options Cardiovasc Med. 2011 Apr13(2):146-58. doi: 10.1007/s11936-011-0113-1.

What is the prognosis for DVT in the thigh?

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