Skip to main content

Complex regional pain syndrome

Medical Professionals

Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Complex regional pain syndrome article more useful, or one of our other health articles.

Synonyms: reflex sympathetic dystrophy, causalgia. Earlier synonyms no longer used: algodystrophy, algoneurodystrophy, Sudeck's atrophy, shoulder-hand syndrome, reflex neurovascular dystrophy, fracture disease

Continue reading below

What is complex regional pain syndrome?

Complex regional pain syndrome (CRPS) is a chronic pain condition characterised by autonomic and inflammatory features.1 The pain and disability associated with CRPS often lead to psychological comorbidities that create a vicious cycle of pain, isolation, and depression.2

There is pain in a limb, usually associated with sensory, motor, autonomic, skin and bone abnormalities. The symptoms are severe and have a debilitating effect. Often there is a history of trauma but the effects are disproportionate to the severity of the injury. It usually only affects one limb but in 7% of people it spreads to affect other limbs.3

Occasionally, it affects parts of the body other than the limbs.4 It may also arise in the absence of injury.

The exact pathophysiology is unclear but complex regional pain syndrome is not a psychological disorder. It appears to result from an individual's abnormal response to injury involving neural inflammation, vasomotor dysfunction and maladaptive neuroplasticity.5

Complex regional pain syndrome has in the past been divided into two disease entities of differing aetiologies:6

  • CRPS I - pain which develops in the absence of identifiable nerve injury (previously called reflex sympathetic dystrophy).

  • CRPS II - pain in the presence of damage to a major nerve (previously called causalgia).

However, these types do not alter management, although they may still be important in medico-legal cases.3



Incidence rates of 26 per 100,000 patient years are reported in Europe.3

Complex regional pain syndrome can affect any age but it is more common with increasing age up to age 70. It is 3-4 times more common in women, in whom it is also more likely to be of a severe type, than in men. In about 60% of the cases it is the arm that is affected, with the leg being affected in 40%. The most frequently reported triggering events are fractures (45%), sprain (18%) and elective surgery (12%). CRPS occurring spontaneously is uncommon (<10%).5

In children complex regional pain syndrome typically peaks in early adolescence and is rare before the age of 6 years.7 It is much more likely to affect the lower limb in children and has an even greater female-to-male preponderance.8

Continue reading below

Risk factors9

  • Female gender.

  • Fibromyalgia.

  • Rheumatoid arthritis.

  • Neuropathic inflammation.

  • Autonomic nervous system alterations.

  • Psychological factors.

Stress has an important role in inducing or perpetuating CRPS in children.10

Complex regional pain syndrome symptoms3

The word 'complex' reflects the variety of symptoms and signs that these patients can present with, in addition to pain. Symptoms usually begin within one month following the inciting event or immobilisation. As the signs and symptoms vary widely, patients can present to various specialities:

  • Orthopaedics - following limb fractures and orthopaedic surgery. Patients may have been discharged but it may be necessary to re-refer to rule out organic pathology - eg, compression of nerves by scar tissue.

  • Rheumatology, neurology and neurosurgery - having been referred to rule out other potential causes of pain.

  • Dermatologists - precipitating factors can be skin conditions, such as herpes zoster, vasculitis and leg ulcers. Complex regional pain syndrome may also present with skin changes (see 'Signs', below).

Delay in diagnosis is common; thus, a thorough history and examination are crucial from the initial consultation3 .

The symptoms of complex regional pain syndrome vary in severity and duration. The characteristic symptom is that of pain - typically burning in nature and out of proportion to the severity of any injury. The affected area , which is not confined to a specific nerve distribution or dermatome, may have other features such as:

  • Sensitivity to touch.

  • Allodynia - perception of pain from a non-painful stimulus.

  • Hyperalgesia - painful stimuli provoke more pain than usual; mechanical and thermal hyperalgesia are especially common.

  • Swelling.

  • Abnormal vasomotor activity - spontaneous temperature changes, either warmer or cooler than the contralateral limb.

  • Abnormal sudomotor activity - spontaneous sweating.

  • Abnormal pilomotor activity - 'goosebumps'.


There are not always any objective findings in these patients. However, the following may occur:

  • The majority of people with CRPS have temperature differences between opposite sides. They may be warmer or cooler and this may be a fluctuating sign (sometimes occurring within a few minutes) depending on room temperature, local temperature of the skin and emotional state. Occasionally, it may occur spontaneously. This may be associated with a change in skin colour.

  • Other skin changes include a shiny, dry or scaly appearance. Hair may be coarse initially, then become thin; nails become brittle and grow faster (initially), then slower; there may be associated rashes, ulcers or pustules which may become infected. Abnormal and spontaneous vasomotor, sudomotor and pilomotor activity also occur.

  • Hard, pitting oedema may occur diffusely over the painful region. There is often a well-demarcated boundary along the skin line - almost diagnostic of the condition, although similar findings occur when patients tie a band around the limb for comfort.

  • Movement may be limited, both because of the pain and because joints are often described as stiff (particularly with difficulty in initiating movements) or muscles weak. Disuse atrophy can ensue. Other muscular disorders include sudden and severe spasms, tremors and involuntary severe jerking and dystonia.

It is also important to look for psychological symptoms which may need to be treated.

Continue reading below


The diagnosis is clinical and may be difficult, particularly in the early stages of the syndrome where there may be little, if any, objective evidence of a problem. The Royal College of Physicians recommends that doctors and other trained therapists use the 'Budapest criteria' to make a diagnosis.3 The clinical diagnosis requires all of the following four to be present:

  • Presence of pain which is disproportionate to the initial causative event.

  • Presence of at least one symptom in three of the four following categories:

    • Sensory - reports hyperalgesia and/or allodynia.

    • Vasomotor - symptoms of temperature differences and/or skin colour changes and/or skin colour asymmetry.

    • Sudomotor/oedema - complains of swelling and/or sweating changes and/or sweating asymmetry.

    • Motor/trophic category - reports reduced range of motion and/or motor dysfunction (including weakness, tremor or dystonia) and/or trophic changes (of the hair, nail or skin).

  • Presence of at least one sign in two or more of the following categories:

    • Sensory - allodynia (to light touch, temperature, deep somatic pressure or joint movement) and/or hyperalgesia (to pinprick).

    • Vasomotor category - signs of temperature differences ( >1°C) and/or skin colour changes and/or skin colour asymmetry.

    • Sudomotor/oedema category - oedema and/or sweating and/or sweating asymmetry.

    • Motor/trophic category - evidence of reduced range of motion and/or motor dysfunction (including weakness, tremor or dystonia) and/or trophic changes (of the hair, nail or skin).

  • No other diagnosis would better explain the signs and symptoms.

This classification means that complex regional pain syndrome can only be diagnosed if there are objective signs in the limb at the time the patient is seen. Many patients experience a delay in diagnosis and some changes (eg, swelling and sweating) may abate over time. In those patients who still have pain and who would have fulfilled the criteria in the past, a diagnosis of CRPS-NOS (not otherwise specified) is made.3

Contrary to what was previously believed, complex regional pain syndrome is not a progressive disease. However, there would appear to be three distinct subtypes11 :

  1. A relatively limited syndrome with predominant vasomotor signs.

  2. A relatively limited syndrome with predominant neuropathic pain/sensory abnormalities.

  3. A florid CRPS which, despite having the shortest pain duration, shows the greatest level of motor and trophic signs and disuse changes.

Prompt diagnosis and early intervention help management and aid recovery. Complications which occur from limb disuse and the psychological effects of living with an undiagnosed chronic pain are also prevented by prompt diagnosis.

Differential diagnosis


  • No blood tests support or exclude the diagnosis.

  • The diagnosis is clinical and over-reliance on investigations is unnecessary.3

  • It is worth noting that X-rays, electromyography (EMG), nerve conduction studies, CT scans and MRI studies may all be entirely normal.

  • Definitive tests of nerve damage, such as EMG, needed to differentiate between CRPS I and CRPS II, are considered unnecessarily painful to CRPS patients11 .

  • Thermography may confirm changes in body temperature that are common in CRPS.

Complex regional pain syndrome treatment and management

There is currently no strong consensus regarding the optimal management of complex regional pain syndrome although a multitude of interventions have been described and are commonly used.12

NICE guidance on chronic pain

The National Institute for Health and Care Excellence (NICE) has produced new guidance on chronic primary and secondary pain.13 The main principles recommended for management of chronic primary pain include:

  • Encouragement of self-management from an early stage as part of a long-term management strategy.

  • A focus on non-pharmacological management.

  • Consideration of the following non-pharmacological interventions:

    • Cognitive behavioural therapy (CBT).

    • Acceptance and commitment therapy (ACT).

    • A single course of acupuncture.

  • Treatment should be aimed at improving function (with realistic goals) and changing pain behaviour.

  • Physical activity and exercise programmes should be encouraged.

  • Management should be centred on a multidisciplinary approach.

  • With respect to pharmacological treatment:

    • Antiepileptic drugs including gabapentinoids should not be initiated, unless gabapentinoids are offered as part of a clinical trial for CRPS.

    • There should be a recognition of the risk of dependence with gabapentin and pregabalin.

    • Local anaesthetics (topical or intravenous) should not be initiated, unless as part of a clinical trial for CRPS. There remains a lack of high- quality evidence to support or refute the use of local anaesthetic sympathetic blockade for CRPS.14

    • Because of the lack of evidence for effectiveness, and the high risk of dependence, of opioid analgesics, even short-term use could be harmful. Treatment with an opioid should therefore not be initiated for people with chronic primary pain, and patients currently prescribed such treatment should be made aware of the risks of medicine treatments, and of the alternatives available.

    • Cannabis-based medicinal products should not be used.

The separate Chronic Pain article gives more details.

For the purposes of management of CRPS, assessment of severity is divided as follows:3

  • Mild CRPS: few signs of pain-related disability or distress. Pain can be managed with simple analgesics or neuropathic medications.

  • Moderate-to-severe CRPS:

    • Moderate-to-severe signs and/or symptoms at presentation.

    • Dystonia.

    • Failure of response to treatment.

    • Continued deterioration or only short-lived improvements.

General principles

The Royal College of Physicians provides four 'pillars' of therapy: education, pain reduction, physical rehabilitation and attention to psychological needs, with the aim being to improve the quality of life.3

  • Restoring function is pivotal.

  • The key approach is a multidisciplinary one but should be centred around the GP and pain teams.

  • Pain-related fear may be more disabling than pain itself.

  • Ensure the patient's care does not become fragmented; they may end up seeing several different specialities.


Referral from primary care is necessary for the following:3

  • Confirmation of CRPS.

  • Exclusion of other causes of the symptoms/signs.

  • Functional rehabilitation.

  • Helping to control difficult symptoms including pain, distress and associated disability.

Mild confirmed cases can be managed in primary care provided symptoms are responding to treatment, although referral to a multidisciplinary pain clinic may be necessary.

Moderate-to-severe complex regional pain syndrome should be referred to either a multidisciplinary pain clinic or specialist unit.3


Patient information and education about complex regional pain syndrome is fundamental.

  • Only with a correct diagnosis and information about the condition can a patient be actively engaged in self-management, goal setting and pacing and ultimately take control of their condition.

  • Patients need to understand that they will experience pain both when they exercise too much but also when they exercise too little; they need to be taught how to find the middle ground.11

  • A survey of people with CRPS stressed the significance of telling those with CRPS that it can become a chronic condition, so that the importance of rehabilitation is emphasised.15

Pain reduction3 11

  • No medications are specifically licensed for CRPS

  • Simple analgesics to begin with - eg, non-steroidal anti-inflammatory drugs (NSAIDs) and gradually up-titrate, such that limb use can be encouraged with gentle exercise.

  • If pain is not reduced to a mild level by 3-4 weeks then use medication for neuropathic pain (tricyclic antidepressants or gabapentin).

  • Pain flares are normal but usually settle over a few days or weeks. Medications should be continued with a temporary reduction in intensity of physical therapy.

  • Medications may also be needed for associated depression if present.

  • Bisphosphonates: some patients with CRPS have evidence of active bone resorption which can be painful. Inhibiting bone resorption may thus reduce bony pain. Pamidronate, as a one-off treatment, can be used with CRPS of less than six months' duration. Other bisphosphonates have also been shown to reduce pain significantly.

  • Baclofen may be needed for dystonia.

  • Capsaicin is not recommended as it can be intolerably painful.

Physical and vocational rehabilitation3

  • Physical therapy is the cornerstone of treatment and should be considered in everyone. It should be started early, regardless of which speciality the patient is seeing when the initial diagnosis is made.

  • However, evidence for the benefit of physiotherapy for pain and disability in adults with complex regional pain syndrome is limited.16

  • Frequent attention to the affected limb and desensitisation by stroking the affected limb, using various fabric modalities whilst observing the limb, is a pragmatic initial approach.

  • Multidisciplinary pain management programmes, which are run in groups, are available in specialised settings.

  • Intensive exercise therapy may be particularly effective in children, especially when combined with cognitive psychological approaches.10 This has been shown to be practicable in an outpatient setting7 .

  • Psychosocial factors may lead to reduced response to rehabilitation and should be actively looked for and corrected. This includes previous negative experiences, poor coping and depression.

  • Treatment approaches used in rehabilitation for CRPS are wide and include education and support, desensitisation, postural control and stress loading of the affected limb.

  • Specialised units may also undertake the following more therapeutic strategies, which are thought may reset abnormal, central, sensory processing.11 There is some low-quality evidence to support their use:16

    • Mirror visual feedback involves the patient describing their affected and unaffected limbs with their eyes closed, followed by imagined movements and then looking at their arm or leg in a mirror, without moving it, while trying to establish ownership of the mirrored limb.

    • Graded motor imagery involves the patient imagining moving their affected limb into the position demonstrated first in pictures and then in a reflected image of their unaffected limb moving.

Other treatments3

  • Spinal cord stimulation is used in specialist centres for patients who have not responded to a multidisciplinary approach. There is some evidence that the effects of this treatment reduce over time.

  • Specialist centres may also use clonidine and local anaesthesia injection into the epidura, local anaesthetic injection into the sympathetic chain, intravenous regional sympathetic blocks or interscalene indwelling catheters. The evidence for their use is inconclusive but if they reduce pain (as opposed to simply producing a sympathetic block) they can provide a less painful 'window of opportunity' for rehabilitation techniques.11

  • The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has been used in intractable CRPS but has to be given in anaesthetic doses.

  • There is evidence that intravenous regional blockade with guanethidine is ineffective.12

Psychological support

Integration of psychological methods, including cognitive behavioural therapy, relaxation techniques, counseling and psychotherapy, alongside medical and intensive physical and occupational therapy, may be particularly helpful in CRPS.

A psychological evaluation by an expert in chronic pain may be necessary to identify factors which might be contributing to poor progress. Patients with complex regional pain syndrome commonly report the following psychological issues:

  • Difficulty relaxing.

  • Low self-esteem.

  • Inappropriate/ineffective coping strategies.

  • Difficulty accessing/accepting social support.

  • Suicidal ideation.

Unfortunately, a Cochrane review concluded that although there is a wide range of therapies used to treat CRPS, there is little evidence of their effectiveness and very few large controlled trials have been undertaken; further well-designed trials are needed.12 The interventions thought to hold most promise are bisphosphonates, ketamine and graded motor imagery.17


  • Depression is common.

  • Immobilisation may aggravate pain and stiffness.

  • Skin infections can occur and occasionally may be very severe.


There is no cure for complex regional pain syndrome but the majority of patients will get better. Pain flares are common and not a sign that the condition is worsening. The duration of CRPS varies. Resolution rates in studies have varied widely from 74% in the first year to 36% within six years.5 CRPS developing following a fracture appears to have a more favourable outcome than when it follows a soft-tissue injury, as does 'warm' CRPS (in which impaired thermoregulation leaves the affected limb warmer than normal).

If undiagnosed and untreated, complex regional pain syndrome can spread to all extremities such that the patient is completely incapacitated by the disease. Rehabilitation is subsequently much more difficult and potentially complicated by opiate dependency. The treatment of patients with advanced CRPS is a challenging and time-consuming task. However, if diagnosed early and treated aggressively, prognosis is improved.

In general, paediatric CRPS has a more favourable outcome compared to that experienced by adults10 .

Complex regional pain syndrome prevention

Investigators are studying new approaches to treat complex regional pain syndrome and intervene more aggressively after traumatic injury to lower the patient's chances of developing the disorder. Researchers hope to discover the mechanisms that cause the spontaneous pain of CRPS; that discovery may lead to new ways of blocking pain. There is some evidence the use of vitamin C in patients who have a fractured wrist may reduce their chances of developing CRPS.18

Further reading and references

  • Straube S, Derry S, Moore RA, et al; Cervico-thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome. Cochrane Database Syst Rev. 2013 Sep 2;(9):CD002918. doi: 10.1002/14651858.CD002918.pub3.
  1. Bruehl S; Complex regional pain syndrome. BMJ. 2015 Jul 29;351:h2730. doi: 10.1136/bmj.h2730.
  2. Shim H, Rose J, Halle S, et al; Complex regional pain syndrome: a narrative review for the practising clinician. Br J Anaesth. 2019 Aug;123(2):e424-e433. doi: 10.1016/j.bja.2019.03.030. Epub 2019 May 2.
  3. Complex regional pain syndrome in adults (2nd edition); Royal College of Physicians guideline (July 2018)
  4. Goenka A, Aziz M, Riley P, et al; Complex regional pain syndrome involving the face following snowball injury. Eur J Pediatr. 2014 Mar;173(3):397-400. doi: 10.1007/s00431-013-2159-4. Epub 2013 Sep 24.
  5. Marinus J, Moseley GL, Birklein F, et al; Clinical features and pathophysiology of complex regional pain syndrome. Lancet Neurol. 2011 Jul;10(7):637-48. doi: 10.1016/S1474-4422(11)70106-5.
  6. Misidou C, Papagoras C; Complex Regional Pain Syndrome: An update. Mediterr J Rheumatol. 2019 Mar 28;30(1):16-25. doi: 10.31138/mjr.30.1.16. eCollection 2019 Mar.
  7. Logan DE, Carpino EA, Chiang G, et al; A day-hospital approach to treatment of pediatric complex regional pain syndrome: initial functional outcomes. Clin J Pain. 2012 Nov-Dec;28(9):766-74. doi: 10.1097/AJP.0b013e3182457619.
  8. Logan DE, Williams SE, Carullo VP, et al; Children and adolescents with complex regional pain syndrome: more psychologically distressed than other children in pain? Pain Res Manag. 2013 Mar-Apr;18(2):87-93.
  9. Taylor SS, Noor N, Urits I, et al; Complex Regional Pain Syndrome: A Comprehensive Review. Pain Ther. 2021 Dec;10(2):875-892. doi: 10.1007/s40122-021-00279-4. Epub 2021 Jun 24.
  10. Weissmann R, Uziel Y; Pediatric complex regional pain syndrome: a review. Pediatr Rheumatol Online J. 2016 Apr 29;14(1):29. doi: 10.1186/s12969-016-0090-8.
  11. Harden RN, Oaklander AL, Burton AW, et al; Complex regional pain syndrome: practical diagnostic and treatment guidelines, 4th edition. Pain Med. 2013 Feb;14(2):180-229. doi: 10.1111/pme.12033. Epub 2013 Jan 17.
  12. O'Connell NE, Wand BM, McAuley J, et al; Interventions for treating pain and disability in adults with complex regional pain syndrome. Cochrane Database Syst Rev. 2013 Apr 30;4:CD009416. doi: 10.1002/14651858.CD009416.pub2.
  13. Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain; NICE Guidance (April 2021)
  14. O'Connell NE, Wand BM, Gibson W, et al; Local anaesthetic sympathetic blockade for complex regional pain syndrome. Cochrane Database Syst Rev. 2016 Jul 28;7:CD004598. doi: 10.1002/14651858.CD004598.pub4.
  15. Grieve S, Adams J, McCabe C; 'What I Really Needed Was the Truth'. Exploring the Information Needs of People with Complex Regional Pain Syndrome. Musculoskeletal Care. 2016 Mar;14(1):15-25. doi: 10.1002/msc.1107. Epub 2015 Jun 15.
  16. Smart KM, Wand BM, O'Connell NE; Physiotherapy for pain and disability in adults with complex regional pain syndrome (CRPS) types I and II. Cochrane Database Syst Rev. 2016 Feb 24;2:CD010853. doi: 10.1002/14651858.CD010853.pub2.
  17. O'Connell NE, Wand BM; When 'strong' might be wrong: evaluating the evidence in CRPS management. Eur J Pain. 2013 Feb;17(2):143-4. doi: 10.1002/j.1532-2149.2012.00238.x.
  18. Zollinger PE, Tuinebreijer WE, Breederveld RS, et al; Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures? A randomized, controlled, multicenter dose-response study. J Bone Joint Surg Am. 2007 Jul;89(7):1424-31.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

symptom checker

Feeling unwell?

Assess your symptoms online for free