Can I take 0palmon and Ibuprofen together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Taking Opalmon (limaprost) and ibuprofen together can significantly increase your risk of serious bleeding, particularly in the stomach or intestines. It can also make your blood take longer to clot if you cut yourself. Additionally, both medicines can affect your kidney function, and taking them together increases the risk of kidney problems.
In this article:
Continue reading below
Why this happens
Opalmon is a prostaglandin analogue that prevents blood platelets from sticking together. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that also thins the blood and can irritate the lining of the stomach. When used together, their blood-thinning effects are added together, making bleeding much more likely. Both drugs also reduce blood flow to the kidneys.
What you should do
Back to contentsYou should avoid taking ibuprofen while you are taking Opalmon unless your doctor has specifically told you to do so. If you need pain relief, ask your pharmacist or doctor for a safer alternative, such as paracetamol. Seek medical help immediately if you notice signs of bleeding, such as black or tarry stools, coughing up blood, or severe stomach pain.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Ashwagandha and Vitamin d2 together?
There are no known significant interactions between ashwagandha and vitamin D2 (ergocalciferol). It is generally considered safe to take these two supplements together.

Treatment and medication
Can I take Atorvastatin and Magnesium together?
Taking magnesium antacids at the same time as atorvastatin can lower the amount of the statin medicine that your body absorbs. This might make your cholesterol treatment less effective.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.