Can I take 1.0mg and Amitriptyline together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking amitriptyline with alcohol can make you feel much more drowsy, dizzy, and uncoordinated than usual. It can also slow down your breathing and affect your heart rate.
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Why this happens
Both amitriptyline and alcohol are 'central nervous system depressants'. This means they both slow down brain activity. When taken together, their effects add up, making the sedative (sleep-inducing) effect much stronger and potentially dangerous.
What you should do
Back to contentsIt is best to avoid drinking alcohol while taking amitriptyline, especially when you first start the medication or if your dose has just been increased. If you do choose to drink, keep it to a very small amount and do not drive or operate machinery.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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