Can I take 1.25 and Msm together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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There is no known interaction between aspirin (75mg, often referred to as '1.25' grains in older measurements) and MSM (Methylsulfonylmethane). However, both substances can have a mild effect on how your blood clots. Taking them together might slightly increase the risk of bruising or bleeding, although this is not well-documented in clinical studies.
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Why this happens
Aspirin works by stopping platelets (blood cells) from sticking together to form clots. MSM is thought by some researchers to have a very mild 'blood-thinning' effect, though the exact way this happens is not fully understood. Combining two substances with similar effects can theoretically increase bleeding risk.
What you should do
Back to contentsIt is generally considered safe to take these together, but you should inform your doctor or pharmacist. Watch out for any unusual bruising, nosebleeds, or bleeding gums. If you are scheduled for surgery, tell your surgeon you are taking MSM, as they may ask you to stop taking it a week or two beforehand.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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