Can I take 1.25 and Vitamin a together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Taking 1.25 (calcitriol) and Vitamin A together can lead to dangerously high levels of calcium in your blood. This can cause symptoms like nausea, vomiting, constipation, and in severe cases, damage to your kidneys or heart. Additionally, high doses of Vitamin A can interfere with how calcitriol works, potentially making your treatment less effective or more toxic.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Calcitriol (1.25-dihydroxyvitamin D3) is a very potent form of Vitamin D that helps your body absorb calcium. Vitamin A also influences bone metabolism and calcium levels. When taken together, they can have an 'additive' effect, pushing calcium levels too high. Furthermore, Vitamin A can compete with Vitamin D at a cellular level, disrupting the balance of how your body uses these nutrients.
What you should do
Back to contentsYou should speak to your doctor or pharmacist before taking Vitamin A supplements if you are prescribed calcitriol (1.25). Your doctor may need to monitor your blood calcium levels more frequently or adjust your doses. Avoid taking over-the-counter multivitamins containing Vitamin A without professional medical advice.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Folitrax and Hqtor together?
Taking Folitrax (methotrexate) and Hqtor (hydroxychloroquine) together can increase the risk of side effects, particularly those affecting the liver. However, these two medicines are very commonly prescribed together by specialists to treat conditions like rheumatoid arthritis. While they work well as a team to control inflammation, they require careful monitoring.

Treatment and medication
Can I take Ashwagandha and Vitamin d2 together?
There are no known significant interactions between ashwagandha and vitamin D2 (ergocalciferol). It is generally considered safe to take these two supplements together.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.