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Can I take 1.5mg and Amitriptyline together?

Drug interaction guide

Combining alcohol and amitriptyline can make you feel extremely drowsy, dizzy, and confused. It significantly increases the risk of falls and accidents. It can also slow down your breathing and heart rate to dangerous levels.

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Why this happens

Both alcohol and amitriptyline are 'central nervous system depressants'. This means they both slow down brain activity. When taken together, their effects add up, making the sedative (sleep-inducing) effect much stronger than usual.

It is best to avoid or strictly limit alcohol while taking amitriptyline. Do not drive or operate machinery if you have consumed any alcohol with this medication. If you feel unusually sleepy or have difficulty breathing, seek medical help immediately.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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