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Can I take 1.5mg and Spironolactone together?

Drug interaction guide

Taking these two medicines together can cause your potassium levels to become dangerously high (hyperkalaemia). It can also lead to a significant drop in blood pressure and may affect how well your kidneys work.

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Why this happens

Both medicines work to lower blood pressure, so their effects add together. More importantly, both drugs stop the body from getting rid of potassium. Spironolactone is a 'potassium-sparing' diuretic, and Ramipril (an ACE inhibitor) also causes the body to retain potassium. When used together, potassium can build up to levels that are unsafe for the heart.

You must only take these two medicines together if they have been specifically prescribed by your doctor with full knowledge of both. You will need regular blood tests to monitor your potassium levels and kidney function. If you feel dizzy, lightheaded, or notice an irregular heartbeat, contact your doctor immediately.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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