Can I take 10 and Guanfacine prolonged-release together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Combining alcohol with guanfacine can make you feel extremely sleepy, dizzy, or lightheaded. It can also cause your blood pressure to drop too low, which might lead to fainting.
In this article:
Continue reading below
Why this happens
Both alcohol and guanfacine have a 'depressant' effect on the central nervous system and both can lower blood pressure. When taken together, these effects are added together (additive effect), making the side effects much stronger and more dangerous.
What you should do
Back to contentsIt is best to avoid or strictly limit alcohol while taking guanfacine. Do not drive or operate machinery if you feel drowsy or dizzy. If you feel faint when standing up, sit or lie down immediately and speak to your doctor.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Treatment and medication
Can I take Atorvastatin and Magnesium together?
Taking magnesium antacids at the same time as atorvastatin can lower the amount of the statin medicine that your body absorbs. This might make your cholesterol treatment less effective.
Treatment and medication
Can I take Desmopressin and Ketoconazole together?
Taking these two medicines together can significantly increase the amount of desmopressin in your blood. This can lead to your body holding onto too much water, which can cause a dangerous drop in your blood salt levels (hyponatraemia). Symptoms to watch for include severe headache, nausea, vomiting, confusion, or feeling very drowsy.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.