Can I take 10 and Tramadol together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Combining alcohol and tramadol can lead to dangerous levels of drowsiness, dizziness, and breathing difficulties. In severe cases, this combination can cause you to stop breathing or lead to a fatal overdose. Both substances also increase the risk of seizures (fits).
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Both alcohol and tramadol are 'central nervous system depressants'. This means they both slow down brain activity and the parts of the brain that control breathing. When taken together, their effects are added together, making the side effects much more powerful and dangerous.
What you should do
Back to contentsYou must not drink alcohol while taking tramadol. Even small amounts of alcohol can significantly increase the risk of life-threatening side effects. If you feel unusually sleepy, have shallow breathing, or feel faint, seek emergency medical help immediately.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Aged garlic extract and Calcium together?
There is no known significant interaction between aged garlic extract and calcium supplements. They are generally considered safe to take together.

Treatment and medication
Can I take Desmopressin and Ketoconazole together?
Taking these two medicines together can significantly increase the amount of desmopressin in your blood. This can lead to your body holding onto too much water, which can cause a dangerous drop in your blood salt levels (hyponatraemia). Symptoms to watch for include severe headache, nausea, vomiting, confusion, or feeling very drowsy.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.