Can I take 100 and Sertraline together?
Drug interaction guide
Originally published 14 Mar 2026
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Taking 5-HTP with sertraline can lead to a very serious and potentially life-threatening condition called serotonin syndrome. This happens when there is too much of the chemical serotonin in your brain and body. Symptoms can include shivering, sweating, a very high temperature, fast heartbeat, muscle stiffness, twitching, confusion, and agitation.
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Why this happens
Sertraline is an SSRI (Selective Serotonin Reuptake Inhibitor) that prevents the body from clearing serotonin. 5-HTP is a building block that the body uses to create more serotonin. When used together, they cause an excessive and dangerous buildup of serotonin.
What you should do
Back to contentsDo not take 5-HTP while you are taking sertraline. If you have already taken them together and feel unwell, seek medical help immediately. Always talk to your doctor or pharmacist before starting any herbal supplements or over-the-counter remedies alongside your prescription medication.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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