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Can I take 12.5mg and Levothyroxine together?

Drug interaction guide

Taking sildenafil (Viagra) and levothyroxine together is generally safe, but there is a small chance that sildenafil could slightly change how much thyroid hormone is in your blood. This might make your thyroid medication slightly more or less effective.

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Why this happens

Both medications are processed by the liver. Some studies suggest that sildenafil might interfere with the proteins that carry thyroid hormone through your blood, or affect the enzymes that break the drugs down, though this effect is usually very small.

You can take these medicines together, but it is important to be consistent. If you start taking sildenafil regularly, your doctor may want to check your thyroid levels (TSH test) to ensure your levothyroxine dose is still correct. Always take your levothyroxine on an empty stomach, at least 30 to 60 minutes before breakfast, to ensure it is absorbed properly.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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