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Can I take 150 and Irbesartan together?

Drug interaction guide

Taking ibuprofen and irbesartan together can increase the risk of kidney problems and may cause your blood pressure to rise. It can also lead to high levels of potassium in your blood.

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Why this happens

Irbesartan works by relaxing blood vessels to lower blood pressure. Ibuprofen (an NSAID) can cause the body to hold onto salt and water, which raises blood pressure and works against the irbesartan. Both drugs also affect how blood flows through the kidneys; when used together, they can reduce the kidneys' ability to filter blood properly.

You should speak to your doctor before taking these medicines together. If your doctor confirms it is necessary, they may want to monitor your kidney function and blood pressure regularly. Seek medical advice if you notice decreased urination, swelling in your legs or ankles, or unusual tiredness. For pain relief, paracetamol is usually a safer alternative, but you should still limit alcohol intake when taking it.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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