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Can I take 150 and Nasonex actuation nasal spray together?

Drug interaction guide

There is no known interaction between paracetamol (the active ingredient in 150mg tablets or suppositories) and Nasonex (mometasone) nasal spray. These medicines work in different ways and are processed by different parts of the body.

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Why this happens

Paracetamol is a painkiller and fever reducer that works throughout the body. Nasonex is a corticosteroid spray that works locally in the nose to reduce inflammation. Because Nasonex is applied directly to the nasal lining, very little of the medicine enters the bloodstream, making an interaction with paracetamol highly unlikely.

It is safe to use these two medicines together. However, when taking paracetamol, it is best to avoid or strictly limit alcohol, as combining them increases the risk of liver damage. Always follow the dosage instructions on the packaging for both products.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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